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View Structure Prediction Details

Protein: IST2
Organism: Saccharomyces cerevisiae
Length: 946 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IST2.

Description E-value Query
Range
Subject
Range
IST2_YEAST - Increased sodium tolerance protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IST...
IST2 - Plasma membrane protein that may be involved in osmotolerance, localizes to the mother cell in small...
0.0 [1..915] [1..915]
gi|40354210 - gi|40354210|ref|NP_060513.4| transmembrane protein 16A [Homo sapiens]
0.0 [1..645] [201..940]
gi|110835696, gi... - gi|38614369|gb|AAH62959.1| Anoctamin 1, calcium activated chloride channel [Mus musculus], gi|148686...
0.0 [1..642] [201..933]
gi|85105158 - gi|85105158|ref|XP_961901.1| hypothetical protein [Neurospora crassa OR74A]
gi|32417002, gi|... - gi|32417002|ref|XP_328979.1| hypothetical protein [Neurospora crassa], gi|28923485|gb|EAA32665.1| hy...
0.0 [36..661] [133..726]

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Predicted Domain #1
Region A:
Residues: [1-206]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQTITSLDP NCVIVFNKTS SANEKSLNVE FKRLNIHSII EPGHDLQTSY AFIRIHQDNA  60
   61 KPLFSFLQNL DFIESIIPYH DTELSDDLHK LISISKSKIL EAPKQYELYN LSNLTNNPKQ 120
  121 SLYFAFLQNY IKWLIPFSFF GLSIRFLSNF TYEFNSTYSL FAILWTLSFT AFWLYKYEPF 180
  181 WSDRLSKYSS FSTIEFLQDK QKAQKK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [207-396]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASSVIMLKKC CFIPVALLFG AILLSFQLYC FALEIFIKQI YNGPMISILS FLPTILICTF  60
   61 TPVLTVIYNK YFVEPMTKWE NHSSVVNAKK SKEAKNFVII FLSSYVPLLI TLFLYLPMGH 120
  121 LLTAEIRTKV FNAFSILARL PTHDSDFIID TKRYEDQFFY FIVINQLIQF SMENFVPSLV 180
  181 SIAQQKINGP 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [397-621]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPNFVKAESE IGKAQLSSSD MKIWSKVKSY QTDPWGATFD LDANFKKLLL QFGYLVMFST  60
   61 IWPLAPFICL IVNLIVYQVD LRKAVLYSKP EYFPFPIYDK PSSVSNTQKL TVGLWNSVLV 120
  121 MFSILGCVIT ATLTYMYQSC NIPGVGAHTS IHTNKAWYLA NPINHSWINI VLYAVFIEHV 180
  181 SVAIFFLFSS ILKSSHDDVA NGIVPKHVVN VQNPPKQEVF EKIPS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [622-720]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEFNSNNEKE LVQRKGSANE KLHQELGEKQ PASSANGYEA HAATHANNDP SSLSSASSPS  60
   61 LSSSSSSSKT GVVKAVDNDT AGSAGKKPLA TESTEKRNS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [721-946]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVKVPTVGSY GVAGATLPET IPTSKNYYLR FDEDGKSIRD AKSSAESSNA TNNNTLGTES  60
   61 KLLPDGDAVD ALSRKIDQIP KIAVTGGENN ENTQAKDDAA TKTPLIKDAN IKPVVNAAVN 120
  121 DNQSKVSVAT EQTKKTEVST KNGPSRSIST KETKDSARPS NNNTTTTTTT DATQPHHHHH 180
  181 HHRHRDAGVK NVTNNSKTTE SSSSSSAAKE KPKHKKGLLH KLKKKL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle