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View Structure Prediction Details

Protein: VPS66
Organism: Saccharomyces cerevisiae
Length: 300 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS66.

Description E-value Query
Range
Subject
Range
VPS66 - Cytoplasmic protein of unknown function involved in vacuolar protein sorting.
LOA1_YEAST - Lysophosphatidic acid:oleoyl-CoA acyltransferase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 /...
gi|151942912 - gi|151942912|gb|EDN61258.1| vacuolar sorting protein [Saccharomyces cerevisiae YJM789]
gi|190408063 - gi|190408063|gb|EDV11328.1| vacuolar protein sorting protein 66 [Saccharomyces cerevisiae RM11-1a]
gi|207340267 - gi|207340267|gb|EDZ68672.1| YPR139Cp-like protein [Saccharomyces cerevisiae AWRI1631]
2.0E-86 [1..300] [1..300]
gi|85090151 - gi|85090151|ref|XP_958281.1| hypothetical protein NCU04580 [Neurospora crassa OR74A]
gi|32406646, gi|... - gi|32406646|ref|XP_323936.1| predicted protein [Neurospora crassa], gi|28950020|emb|CAD70775.1| cons...
6.0E-59 [1..296] [1..331]
gi|23509675, gi|... - gi|23509675|ref|NP_702342.1| hypothetical protein PF14_0453 [Plasmodium falciparum 3D7], gi|23497524...
1.0E-54 [1..297] [1..339]
gi|82704478 - gi|82704478|ref|XP_726572.1| hypothetical protein [Plasmodium yoelii yoelii str. 17XNL]
gi|23482034 - gi|23482034|gb|EAA18137.1| hypothetical protein [Plasmodium yoelii yoelii]
2.0E-47 [36..298] [3..285]
GPAT4_MOUSE - Glycerol-3-phosphate acyltransferase 4 OS=Mus musculus GN=Gpat4 PE=1 SV=1
4.0E-44 [26..210] [158..363]
AGPAT9 - 1-acylglycerol-3-phosphate O-acyltransferase 9
7.0E-41 [26..210] [139..344]
gi|26452748, gi|... - gi|29824119|gb|AAP04020.1| unknown protein [Arabidopsis thaliana], gi|26452748|dbj|BAC43455.1| unkno...
9.0E-40 [19..233] [72..307]

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Predicted Domain #1
Region A:
Residues: [1-205]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKYTNWRDN GTGIAPFLPN TIRKPSKVMT ACLLGILGVK TIIMLPLIML YLLTGQNNLL  60
   61 GLILKFTFSW KEEITVQGIK KRDVRKSKHY PQKGKLYICN CTSPLDAFSV VLLAQGPVTL 120
  121 LVPSNDIVYK VSIREFINFI LAGGLDIKLY GHEVAELSQL GNTVNFMFAE GTSCNGKSVL 180
  181 PFSITGKKLK EFIDPSITTM NPAMA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [206-300]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTKKFELQTI QIKTNKTAIT TLPISNMEYL SRFLNKGINV KCKINEPQVL SDNLEELRVA  60
   61 LNGGDKYKLV SRKLDVESKR NFVKEYISDQ RKKRK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.872 0.113 protein targeting to vacuole c.23.1 CheY-like
View Download 0.789 0.113 protein targeting to vacuole c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.704 0.113 protein targeting to vacuole c.23.13 Type II 3-dehydroquinate dehydratase
View Download 0.668 0.113 protein targeting to vacuole c.44.2 Enzyme IIB-cellobiose
View Download 0.649 0.113 protein targeting to vacuole c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.644 0.113 protein targeting to vacuole c.13.2 Anti-sigma factor antagonist SpoIIaa
View Download 0.629 0.113 protein targeting to vacuole c.23.1 CheY-like
View Download 0.618 0.113 protein targeting to vacuole c.47.2 RNA 3'-terminal phosphate cyclase, RPTC, insert domain
View Download 0.600 0.113 protein targeting to vacuole d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.593 0.113 protein targeting to vacuole c.23.6 Cobalamin (vitamin B12)-binding domain
View Download 0.571 0.113 protein targeting to vacuole c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.567 0.113 protein targeting to vacuole d.79.3 L30e-like
View Download 0.546 0.113 protein targeting to vacuole c.3.1 FAD/NAD(P)-binding domain
View Download 0.524 0.113 protein targeting to vacuole c.23.1 CheY-like
View Download 0.520 0.113 protein targeting to vacuole c.23.6 Cobalamin (vitamin B12)-binding domain
View Download 0.473 0.113 protein targeting to vacuole d.68.4 YhbY-like
View Download 0.461 0.113 protein targeting to vacuole c.3.1 FAD/NAD(P)-binding domain
View Download 0.455 0.113 protein targeting to vacuole d.94.1 HPr-like
View Download 0.450 0.113 protein targeting to vacuole d.109.1 Actin depolymerizing proteins
View Download 0.448 0.113 protein targeting to vacuole c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.434 0.113 protein targeting to vacuole d.109.1 Actin depolymerizing proteins
View Download 0.433 0.113 protein targeting to vacuole c.23.5 Flavoproteins
View Download 0.403 0.113 protein targeting to vacuole b.40.2 Bacterial enterotoxins
View Download 0.382 0.113 protein targeting to vacuole c.97.1 Cytidine deaminase-like
View Download 0.381 0.113 protein targeting to vacuole d.58.7 RNA-binding domain, RBD
View Download 0.373 0.113 protein targeting to vacuole c.51.3 B12-dependend dehydatases associated subunit
View Download 0.373 0.113 protein targeting to vacuole c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.356 0.113 protein targeting to vacuole a.156.1 S13-like H2TH domain
View Download 0.348 0.113 protein targeting to vacuole c.55.5 MTH1175-like
View Download 0.347 0.113 protein targeting to vacuole d.58.40 D-ribose-5-phosphate isomerase (RpiA), lid domain
View Download 0.342 0.113 protein targeting to vacuole d.198.1 Type III secretory system chaperone
View Download 0.337 0.113 protein targeting to vacuole c.3.1 FAD/NAD(P)-binding domain
View Download 0.333 0.113 protein targeting to vacuole b.11.1 gamma-Crystallin-like
View Download 0.325 0.113 protein targeting to vacuole a.60.2 RuvA domain 2-like
View Download 0.324 0.113 protein targeting to vacuole c.115.1 Hypothetical protein MTH777 (MT0777)
View Download 0.320 0.113 protein targeting to vacuole c.23.12 Formate/glycerate dehydrogenase catalytic domain-like
View Download 0.320 0.113 protein targeting to vacuole d.58.14 Ribosomal protein S6
View Download 0.311 0.113 protein targeting to vacuole c.49.1 Pyruvate kinase, C-terminal domain
View Download 0.310 0.113 protein targeting to vacuole a.74.1 Cyclin-like
View Download 0.307 0.113 protein targeting to vacuole c.46.1 Rhodanese/Cell cycle control phosphatase
View Download 0.305 0.113 protein targeting to vacuole b.11.1 gamma-Crystallin-like
View Download 0.302 0.113 protein targeting to vacuole a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.300 0.113 protein targeting to vacuole d.68.3 SirA-like
View Download 0.290 0.113 protein targeting to vacuole d.68.7 R3H domain
View Download 0.287 0.113 protein targeting to vacuole c.45.1 (Phosphotyrosine protein) phosphatases II
View Download 0.286 0.113 protein targeting to vacuole a.40.1 Calponin-homology domain, CH-domain
View Download 0.283 0.113 protein targeting to vacuole d.74.4 Prokaryotic AspRS, insert domain
View Download 0.282 0.113 protein targeting to vacuole d.58.13 Anticodon-binding domain of PheRS
View Download 0.267 0.113 protein targeting to vacuole d.57.1 DNA damage-inducible protein DinI
View Download 0.266 0.113 protein targeting to vacuole d.79.2 Tubulin/Dihydroxyacetone kinase C-terminal domain
View Download 0.265 0.113 protein targeting to vacuole c.55.5 MTH1175-like
View Download 0.265 0.113 protein targeting to vacuole b.55.1 PH domain-like
View Download 0.261 0.113 protein targeting to vacuole b.84.1 Single hybrid motif
View Download 0.259 0.113 protein targeting to vacuole d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.258 0.113 protein targeting to vacuole c.47.1 Thioredoxin-like
View Download 0.253 0.113 protein targeting to vacuole c.23.3 Hypothetical protein MTH538
View Download 0.250 0.113 protein targeting to vacuole c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.239 0.113 protein targeting to vacuole c.36.1 Thiamin diphosphate-binding fold (THDP-binding)
View Download 0.232 0.113 protein targeting to vacuole a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.231 0.113 protein targeting to vacuole d.58.34 Formiminotransferase domain of formiminotransferase-cyclodeaminase.
View Download 0.228 0.113 protein targeting to vacuole c.23.5 Flavoproteins
View Download 0.227 0.113 protein targeting to vacuole c.23.4 Succinyl-CoA synthetase domains
View Download 0.227 0.113 protein targeting to vacuole c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.221 0.113 protein targeting to vacuole c.84.1 Phosphoglucomutase, first 3 domains
View Download 0.216 0.113 protein targeting to vacuole a.22.1 Histone-fold
View Download 0.215 0.113 protein targeting to vacuole d.211.1 Ankyrin repeat
View Download 0.212 0.113 protein targeting to vacuole d.74.2 C-terminal domain of arginine repressor
View Download 0.211 0.113 protein targeting to vacuole b.1.11 PapD-like
View Download 0.211 0.113 protein targeting to vacuole c.30.1 PreATP-grasp domain
View Download 0.210 0.113 protein targeting to vacuole d.109.1 Actin depolymerizing proteins
View Download 0.207 0.113 protein targeting to vacuole c.49.1 Pyruvate kinase, C-terminal domain
View Download 0.204 0.113 protein targeting to vacuole a.60.1 SAM/Pointed domain
View Download 0.203 0.113 protein targeting to vacuole d.169.1 C-type lectin-like
View Download 0.203 0.113 protein targeting to vacuole d.51.1 Eukaryotic type KH-domain (KH-domain type I)


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle