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View Structure Prediction Details

Protein: THI22
Organism: Saccharomyces cerevisiae
Length: 572 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for THI22.

Description E-value Query
Range
Subject
Range
THI22 - Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with T...
0.0 [1..572] [1..572]
SPBP8B7.18c - phosphomethylpyrimidine kinase
THI22_SCHPO - Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2 OS=Schizosaccharomyces pombe (stra...
0.0 [46..569] [36..536]
gi|32416154, gi|... - gi|32416154|ref|XP_328555.1| hypothetical protein [Neurospora crassa], gi|28924762|gb|EAA33874.1| hy...
gi|85109833 - gi|85109833|ref|XP_963110.1| hypothetical protein [Neurospora crassa OR74A]
0.0 [44..567] [10..506]
THIED_COREF - Thiamine biosynthesis multifunctional protein ThiED OS=Corynebacterium efficiens (strain DSM 44549 /...
THED_COREF, THIE... - Thiamine biosynthesis multifunctional protein ThiED OS=Corynebacterium efficiens GN=thiED PE=3 SV=1,...
0.0 [27..571] [195..736]
gi|21324231, gi|... - gi|23308850|ref|NP_600680.2| thiamine-phosphate pyrophosphorylase [Corynebacterium glutamicum ATCC 1...
0.0 [46..571] [7..520]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [44..539] [10..500]
gi|3171002 - gi|3171002|gb|AAC27706.1| putative kinase Pak1p [Pichia angusta]
3.0E-97 [44..571] [31..587]

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Predicted Domain #1
Region A:
Residues: [1-320]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVIILLGLCT LGFPRTAFCP SIMTNSTVSI NTPPPYLTLA CNEKLPTVMS IAGSDSSGGA  60
   61 GVEADIKTIT AHRCYAMTCV TTLTAQTPVK VYGAHNIPKK MVSQILDANL QDMKCNVIKT 120
  121 GMLTVDAIEV LHEKLLQLGE NRPKLVIDPV LCAASDSSPT GKDVVSLIIE KISPFADILT 180
  181 PNISDCFMLL GENREVSKLQ DVLEIAKDLS RITNCSNILV KGGHIPCDDG KEKHITDVLY 240
  241 LGAEQKFITF KGQFVNTTRT HGAGCTLASA IASNLARGYS LSQSVYGGIE YVQNAIAIGC 300
  301 DVTKKAVKVG PINHVYAVEI 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 308.9794
Match: 1jxhA_
Description: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase (HMP-phosphate kinase, ThiD)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphomethylpyrimidine kinase activity 3.972577109569 bayes_pls_golite062009
kinase activity 2.74755351135221 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.43969902311075 bayes_pls_golite062009
carbohydrate kinase activity 2.34445983129813 bayes_pls_golite062009
thiaminase activity 2.33383885490808 bayes_pls_golite062009
transcription regulator activity 2.31951903725366 bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor 2.29466565429735 bayes_pls_golite062009
transferase activity 2.15883296431019 bayes_pls_golite062009
nucleic acid binding 2.14277879659132 bayes_pls_golite062009
DNA binding 1.96007866678724 bayes_pls_golite062009
catalytic activity 1.74474587246986 bayes_pls_golite062009
binding 1.4216897826135 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.37866801006693 bayes_pls_golite062009
hydroxyethylthiazole kinase activity 1.28568044601242 bayes_pls_golite062009
thiamin-phosphate diphosphorylase activity 1.27602595951972 bayes_pls_golite062009
transcription factor activity 1.22047633822494 bayes_pls_golite062009
phosphofructokinase activity 0.37205329607884 bayes_pls_golite062009
pyridoxal kinase activity 0.217863391052366 bayes_pls_golite062009
protein binding 0.117280046908929 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [321-572]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLEKMLTDEC FTASDAVPKK PIEGSLDKIP GGSFFNYLIN HPKVKPHWDA YVNHEFVKRV  60
   61 ADGTLERKKF QFFIEQDYLY LIDYVRVCCV TGSKSPTLED LEKDLVIADC ARNELNEHER 120
  121 RLREEFGVKD PDYLQKIKRG PALRAYCRYL IDISRRGNWQ EIVVALNPCL MGYVYAVDKV 180
  181 KDKITAAEGS IYSEWCDTCA SSFCYQAVLE GERLMNHILE TYPPDQLDSL VTIFARGCEL 240
  241 ETNFWTAAME YE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.47421036599568 bayes_pls_golite062009
binding 1.80342520508546 bayes_pls_golite062009
transcription activator activity 0.765671114434415 bayes_pls_golite062009
catalytic activity 0.476060647762462 bayes_pls_golite062009
protein binding 0.438212622992804 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle