YRC Public Data Repository - Protein Structure Prediction

Protein:	MRI1
Organism:	Saccharomyces cerevisiae
Length:	411 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MRI1.

Description	E-value	Query Range	Subject Range
MTNA_YEAST - Methylthioribose-1-phosphate isomerase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=M... MTNA_YEAS7 - Methylthioribose-1-phosphate isomerase OS=Saccharomyces cerevisiae (strain YJM789) GN=MRI1 PE=3 SV=1 MTNA_YEAS1 - Methylthioribose-1-phosphate isomerase OS=Saccharomyces cerevisiae (strain RM11-1a) GN=MRI1 PE=3 SV=... MTNA_YEAS6 - Methylthioribose-1-phosphate isomerase OS=Saccharomyces cerevisiae (strain AWRI1631) GN=MRI1 PE=3 SV... MRI1 - 5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosp... MTNA_YEAS8 - Methylthioribose-1-phosphate isomerase OS=Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de ...	0.0	[1..411]	[1..411]
MTNA_THEMA - Methylthioribose-1-phosphate isomerase OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 /... MTNA_THEMA - Methylthioribose-1-phosphate isomerase OS=Thermotoga maritima GN=mtnA PE=1 SV=1	0.0	[1..410]	[1..340]
MTNA_NOSP7 - Methylthioribose-1-phosphate isomerase OS=Nostoc punctiforme (strain ATCC 29133 / PCC 73102) GN=mtnA...	0.0	[1..410]	[1..352]
MTNA_NOSS1 - Methylthioribose-1-phosphate isomerase OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=mtnA PE=3 SV=1 gi\|25315920 - pir\|\|AG2251 translation initiation factor IF-2B alpha chain [imported] - Nostoc sp. (strain PCC 7120...	0.0	[10..399]	[4..335]
MTNA_PSEAE - Methylthioribose-1-phosphate isomerase OS=Pseudomonas aeruginosa GN=mtnA PE=3 SV=1 gi\|84326077, gi\|... - gi\|84326077\|ref\|ZP_00974107.1\| COG0182: Predicted translation initiation factor 2B subunit, eIF-2B a... gi\|194547116, gi... - gi\|84319996\|ref\|ZP_00968382.1\| COG0182: Predicted translation initiation factor 2B subunit, eIF-2B a... MTNA_PSEAE - Methylthioribose-1-phosphate isomerase OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PR... MTNA_PSEAB - Methylthioribose-1-phosphate isomerase OS=Pseudomonas aeruginosa (strain UCBPP-PA14) GN=mtnA PE=3 SV... gi\|107102699 - gi\|107102699\|ref\|ZP_01366617.1\| hypothetical protein PaerPA_01003765 [Pseudomonas aeruginosa PACS2] MTNA_PSEA8 - Methylthioribose-1-phosphate isomerase OS=Pseudomonas aeruginosa (strain LESB58) GN=mtnA PE=3 SV=1	0.0	[3..405]	[6..348]
MTNA_SYNEL - Methylthioribose-1-phosphate isomerase OS=Synechococcus elongatus GN=mtnA PE=3 SV=1 MTNA_THEEB - Methylthioribose-1-phosphate isomerase OS=Thermosynechococcus elongatus (strain BP-1) GN=mtnA PE=3 S...	0.0	[10..404]	[12..348]
MTNA_RHIME - Methylthioribose-1-phosphate isomerase OS=Rhizobium meliloti GN=mtnA PE=3 SV=1 MTNA_RHIME - Methylthioribose-1-phosphate isomerase OS=Rhizobium meliloti (strain 1021) GN=mtnA PE=3 SV=1	0.0	[5..411]	[10..360]
MTNA_SYNY3 - Methylthioribose-1-phosphate isomerase OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN=mtnA PE=3 ... gi\|7447869 - pir\|\|S76472 hypothetical protein - Synechocystis sp. (strain PCC 6803) MTNA_SYNY3 - Methylthioribose-1-phosphate isomerase OS=Synechocystis sp. (strain ATCC 27184 / PCC 6803 / N-1) GN=...	0.0	[7..406]	[9..350]
MTNA_XANC8 - Methylthioribose-1-phosphate isomerase OS=Xanthomonas campestris pv. campestris (strain 8004) GN=mtn... MTNA_XANCP - Methylthioribose-1-phosphate isomerase OS=Xanthomonas campestris pv. campestris GN=mtnA PE=3 SV=1 MTNA_XANCP - Methylthioribose-1-phosphate isomerase OS=Xanthomonas campestris pv. campestris (strain ATCC 33913 /... MTNA_XANCB - Methylthioribose-1-phosphate isomerase OS=Xanthomonas campestris pv. campestris (strain B100) GN=mtn...	0.0	[4..406]	[11..349]
E2B_AQUAE, EI2B_... - Methylthioribose-1-phosphate isomerase OS=Aquifex aeolicus GN=mtnA PE=3 SV=1, Putative translation i... MTNA_AQUAE - Methylthioribose-1-phosphate isomerase OS=Aquifex aeolicus (strain VF5) GN=mtnA PE=3 SV=1	0.0	[8..404]	[133..452]

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Predicted Domain #1

Region A:
Residues: [1-411]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLEAIVFDR SEPENVSVKV LDQLLLPYTT KYVPIHTIDD GYSVIKSMQV RGAPAIAIVG  60
   61 SLSVLTEVQL IKHNPTSDVA TLYSLVNWES TKTVLNKRLD FLLSSRPTAV NLSNSLVEIK 120
  121 NILKSSSDLK AFDGSLYNYV CELIDEDLAN NMKMGDNGAK YLIDVLQKDG FKDEFAVLTI 180
  181 CNTGSLATSG YGTALGVIRS LWKDSLAKTD KADSGLDNEK CPRMGHVFPL ETRPYNQGSR 240
  241 LTAYELVYDK IPSTLITDSS IAYRIRTSPI PIKAAFVGAD RIVRNGDTAN KIGTLQLAVI 300
  301 CKQFGIKFFV VAPKTTIDNV TETGDDIIVE ERNPEEFKVV TGTVINPENG SLILNESGEP 360
  361 ITGKVGIAPL EINVWNPAFD ITPHELIDGI ITEEGVFTKN SSGEFQLESL F

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	168.677781
Match:	PF01008
Description:	Initiation factor 2 subunit family

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [206-411]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAKTDKADSG LDNEKCPRMG HVFPLETRPY NQGSRLTAYE LVYDKIPSTL ITDSSIAYRI  60
   61 RTSPIPIKAA FVGADRIVRN GDTANKIGTL QLAVICKQFG IKFFVVAPKT TIDNVTETGD 120
  121 DIIVEERNPE EFKVVTGTVI NPENGSLILN ESGEPITGKV GIAPLEINVW NPAFDITPHE 180
  181 LIDGIITEEG VFTKNSSGEF QLESLF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	58.69897
Match:	1w2wB
Description:	Crystal structure of yeast Ypr118w, a methylthioribose-1-phosphate isomerase related to regulatory eIF2B subunits
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits