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View Structure Prediction Details

Protein: FHL1
Organism: Saccharomyces cerevisiae
Length: 936 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FHL1.

Description E-value Query
Range
Subject
Range
fkh2 - fork head transcription factor Fkh2
FKH2_SCHPO - Fork head protein homolog 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=fkh2 PE=1 SV=1
283.0 [0..257] [866..44]
FOXK2 - forkhead box K2
270.0 [0..282] [812..36]
gi|45190279, gi|... - gi|45190279|ref|NP_984533.1| AEL327Wp [Ashbya gossypii ATCC 10895], gi|44983175|gb|AAS52357.1| AEL32...
gi|44983175 - gi|44983175|gb|AAS52357.1| AEL327Wp [Ashbya gossypii ATCC 10895]
261.0 [0..90] [797..295]
gi|73958174 - gi|73958174|ref|XP_547003.2| PREDICTED: similar to Forkhead box protein K1 (Myocyte nuclear factor) ...
256.0 [0..281] [785..52]
gi|109489518 - gi|109489518|ref|XP_221212.4| PREDICTED: similar to forkhead box K2 isoform 1 [Rattus norvegicus]
255.0 [0..282] [801..177]
gi|157170406 - gi|157170406|gb|AAI52768.1| Forkhead box K2 [synthetic construct]
gi|82937138, gi|... - gi|82937138|ref|XP_917797.1| PREDICTED: similar to forkhead box K2 isoform 1 [Mus musculus], gi|8293...
254.0 [0..282] [801..188]
gi|49644588, gi|... - gi|50310859|ref|XP_455452.1| unnamed protein product [Kluyveromyces lactis], gi|49644588|emb|CAG9816...
gi|49644588 - gi|49644588|emb|CAG98160.1| KLLA0F08206p [Kluyveromyces lactis]
254.0 [0..89] [792..37]
gi|28204898 - gi|28204898|gb|AAH46369.1| Foxk2 protein [Xenopus laevis]
254.0 [0..284] [815..14]

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Predicted Domain #1
Region A:
Residues: [1-235]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDGEMAIIES SNHVGTSSPT TETQFTIDSS ALKDQETKES ITNSPTSEVP IETKLPKSSD  60
   61 IVTEEKHPQN TTTDIENEVE NPVTDDNGNL KLELPDNLDN ADFSKLLEFD AKNDEALFNS 120
  121 NELLSHTMDP VNNIDLTHDH SREVSSKEDI NIEPVNPDED EREKTQDNTA AVKTEGIRNS 180
  181 EDTSIQKDEP TADAIYTDVH KLSVNKDTET LPTLVDEKNN MLHMRNNSIT PIMFQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [236-422]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QHELVGQPPQ NTVTENNSTD AETTQRKLSE PIDASLPLPN EQPTIFAYAR LDFQSFTFYV  60
   61 QTLHAIIGRR SENDFSHKVD VNLGPSKSIS RRHAQIFYNF GTGRFELSII GKNGAFVDDI 120
  121 FVEKGNTVPL RNKTKIQIGQ IPFQFILPEQ ERNDDSKSPE NADIAESEIN TRNLKKNEPK 180
  181 SKKKITT

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 14.14
Match:
Description: No description for 1gxcA was found.

Predicted Domain #3
Region A:
Residues: [423-581]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAKPKKAQTK PAVKKEKKPP KIPKKVYTLE EIPVEYRTKP TVSYSAMLTT CIRKYSTAKG  60
   61 MSLSEIYAGI RELFPYYKYC PDGWQSSVRH NLSLNKSFRK VSKEGKGWLW GLDEEYIAER 120
  121 ERQKKKQSEI AVAKAQAAQL KLEQQQHKLQ QVPQRGKKD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 151.69897
Match: 1d5vA
Description: Adipocyte-transcription factor FREAC-11 (s12, fkh-14)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [582-637]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IVSQRSNVNA RKQNISQTLA ANRAASNRKN TASDNQRTMK YLQEQLVILT RDRKGL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [638-713]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKQVIAAILT QALAMTINQV TQAAKNKGIT GNPLTALMDK NPQHLNLILA AAVNAATAKV  60
   61 TKGEVKQLVN PETTAA

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 11.07
Match:
Description: No description for 1l8mA was found.

Predicted Domain #6
Region A:
Residues: [714-791]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AALAAKAQHS KPIRQPIVQT PHVPDRPPSQ LSASASSHPN NYLHDKQPGS FDPSSLSRFF  60
   61 QPRQNARATS SVAATSVP

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 11.07
Match:
Description: No description for 1l8mA was found.

Predicted Domain #7
Region A:
Residues: [792-861]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AAASQNVDAQ PKPKPAQDND LESESGTSSS SSSSSESGSE SDSGSDDGSA SGSGDNSSTS  60
   61 SESESESDSG 

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 11.07
Match:
Description: No description for 1l8mA was found.

Predicted Domain #8
Region A:
Residues: [862-936]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEVDEKNNKN EKIDSESIKN NESKDDIPSK DENSSNDNRE ISKTDEEGHD SKRRKVSEDI  60
   61 NEGITEVNVS LEEKL

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 11.07
Match:
Description: No description for 1l8mA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle