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View Structure Prediction Details

Protein: SUA7
Organism: Saccharomyces cerevisiae
Length: 345 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SUA7.

Description E-value Query
Range
Subject
Range
TF2B_XENLA - Transcription initiation factor IIB OS=Xenopus laevis GN=gtf2b PE=2 SV=1
2.0E-94 [10..342] [2..316]
TF2B_RAT - Transcription initiation factor IIB OS=Rattus norvegicus GN=Gtf2b PE=2 SV=1
TF2B_MOUSE - Transcription initiation factor IIB OS=Mus musculus GN=Gtf2b PE=1 SV=1
2.0E-93 [10..342] [2..316]
TF2B_MACFA - Transcription initiation factor IIB OS=Macaca fascicularis GN=GTF2B PE=2 SV=1
TF2B_PONAB - Transcription initiation factor IIB OS=Pongo abelii GN=GTF2B PE=2 SV=1
GTF2B - general transcription factor IIB
gi|57088257 - gi|57088257|ref|XP_537085.1| PREDICTED: similar to Transcription initiation factor IIB (General tran...
gi|167773977 - gi|167773977|gb|ABZ92423.1| general transcription factor IIB [synthetic construct]
ENSPTRT00000001764 - null
gi|194035779 - gi|194035779|ref|XP_001929441.1| PREDICTED: similar to Transcription initiation factor IIB (General ...
ENSMMUG000000027... - null, null
TF2B_PONPY - Transcription initiation factor IIB - Pongo pygmaeus (Orangutan)
tr|F2Z4J6|F2Z4J6... - Isoform of Q2KIN8, Transcription initiation factor IIB OS=Bos taurus GN=GTF2B PE=4 SV=1
3.0E-93 [10..342] [2..316]
gi|41054405, gi|... - gi|41054405|ref|NP_955991.1| general transcription factor IIB [Danio rerio], gi|33585882|gb|AAH55569...
3.0E-93 [10..342] [2..316]
gi|195434140, gi... - gi|195434140|ref|XP_002065061.1| GK14874 [Drosophila willistoni], gi|194161146|gb|EDW76047.1| GK1487...
gi|195146744, gi... - gi|195146744|ref|XP_002014344.1| GL19146 [Drosophila persimilis], gi|194106297|gb|EDW28340.1| GL1914...
gi|194859971, gi... - gi|194859971|ref|XP_001969489.1| GG10133 [Drosophila erecta], gi|190661356|gb|EDV58548.1| GG10133 [D...
gi|190616825, gi... - gi|194761835|ref|XP_001963128.1| GF15790 [Drosophila ananassae], gi|190616825|gb|EDV32349.1| GF15790...
gi|220953484 - gi|220953484|gb|ACL89285.1| TfIIB-PA [synthetic construct]
gi|195578215, gi... - gi|195578215|ref|XP_002078961.1| GD23702 [Drosophila simulans], gi|194190970|gb|EDX04546.1| GD23702 ...
FBpp0305673, TfI... - The gene Transcription factor IIB is referred to in FlyBase by the symbol Dmel\TfIIB (CG5193, FBgn00...
3.0E-92 [14..340] [3..313]
TF2B_ARCFU - Transcription initiation factor IIB OS=Archaeoglobus fulgidus GN=tfb PE=3 SV=1
TF2B_ARCFU - Transcription initiation factor IIB OS=Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 ...
9.0E-87 [2..324] [8..324]
TF2B_YEAST - Transcription initiation factor IIB OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SUA7...
SUA7 - Transcription factor TFIIB, a general transcription factor required for transcription initiation and...
1.0E-85 [1..345] [1..345]
TF2B2_ARATH - Transcription initiation factor IIB-2 OS=Arabidopsis thaliana GN=TFIIB2 PE=2 SV=1
8.0E-85 [24..339] [6..309]
TF2B_SOYBN - Transcription initiation factor IIB OS=Glycine max GN=TFIIB1 PE=2 SV=1
4.0E-84 [24..339] [6..310]

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Predicted Domain #1
Region A:
Residues: [1-72]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMTRESIDKR AGRRGPNLNI VLTCPECKVY PPKIVERFSE GDVVCALCGL VLSDKLVDTR  60
   61 SEWRTFSNDD HN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 87.751666
Match: 1dl6A_
Description: Transcription inititiation factor TFIIB, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 5.7605093262441 bayes_pls_golite062009
transcription elongation regulator activity 5.3609198248279 bayes_pls_golite062009
DNA-directed RNA polymerase activity 4.4866621324249 bayes_pls_golite062009
RNA polymerase activity 4.4866621324249 bayes_pls_golite062009
transcription regulator activity 3.36253105801209 bayes_pls_golite062009
nucleic acid binding 2.22594915484417 bayes_pls_golite062009
binding 2.05994835507055 bayes_pls_golite062009
DNA binding 2.01127684131811 bayes_pls_golite062009
positive transcription elongation factor activity 1.80334408907405 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.57988053581899 bayes_pls_golite062009
nucleotidyltransferase activity 1.44591837933239 bayes_pls_golite062009
DNA primase activity 1.01743034310838 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.71113040164375 bayes_pls_golite062009
protein binding 0.557273506579609 bayes_pls_golite062009
catalytic activity 0.434839928397784 bayes_pls_golite062009
RNA polymerase II transcription elongation factor activity 0.33828634213987 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [73-232]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDDPSRVGEA SNPLLDGNNL STRIGKGETT DMRFTKELNK AQGKNVMDKK DNEVQAAFAK  60
   61 ITMLCDAAEL PKIVKDCAKE AYKLCHDEKT LKGKSMESIM AASILIGCRR AEVARTFKEI 120
  121 QSLIHVKTKE FGKTLNIMKN ILRGKSEDGF LKIDTDNMSG 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 279.522879
Match: 1c9bA_
Description: Transcription factor IIB (TFIIB), core domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 6.34389570239956 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 3.19553060844126 bayes_pls_golite062009
protein kinase regulator activity 2.87088741581791 bayes_pls_golite062009
transcription regulator activity 2.795846725429 bayes_pls_golite062009
binding 2.4204867358489 bayes_pls_golite062009
nucleic acid binding 2.04886889839181 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.00665312545368 bayes_pls_golite062009
DNA binding 1.94297811210385 bayes_pls_golite062009
transcription elongation regulator activity 1.69439693414478 bayes_pls_golite062009
kinase regulator activity 1.65109787211976 bayes_pls_golite062009
protein binding 1.47106731485576 bayes_pls_golite062009
transcription factor activity 1.21921365719206 bayes_pls_golite062009
transcription factor binding 0.749278791251235 bayes_pls_golite062009
enzyme regulator activity 0.729629809946521 bayes_pls_golite062009
positive transcription elongation factor activity 0.42590121577004 bayes_pls_golite062009
transcription coactivator activity 0.138191616709499 bayes_pls_golite062009
transcription activator activity 0.0696060248241566 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [233-345]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQNLTYIPRF CSHLGLPMQV TTSAEYTAKK CKEIKEIAGK SPITIAVVSI YLNILLFQIP  60
   61 ITAAKVGQTL QVTEGTIKSG YKILYEHRDK LVDPQLIANG VVSLDNLPGV EKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 279.522879
Match: 1c9bA_
Description: Transcription factor IIB (TFIIB), core domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle