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View Structure Prediction Details

Protein: TIF5
Organism: Saccharomyces cerevisiae
Length: 405 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TIF5.

Description E-value Query
Range
Subject
Range
IF5_YEAST - Eukaryotic translation initiation factor 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ...
gi|151942829 - gi|151942829|gb|EDN61175.1| translation initiation factor eIF5 [Saccharomyces cerevisiae YJM789]
gi|190407984 - gi|190407984|gb|EDV11249.1| eukaryotic translation initiation factor 5 [Saccharomyces cerevisiae RM1...
TIF5 - Translation initiation factor eIF-5; N-terminal domain functions as a GTPase-activating protein to m...
0.0 [1..392] [1..392]
IF5_RAT - Eukaryotic translation initiation factor 5 OS=Rattus norvegicus GN=Eif5 PE=1 SV=1
0.0 [1..395] [1..383]
gi|147900740, gi... - gi|27469870|gb|AAH41737.1| Eif5-prov protein [Xenopus laevis], gi|147900740|ref|NP_001080311.1| euka...
0.0 [1..395] [1..381]
gi|1229140 - gi|1229140|gb|AAC50572.1| translation initiation factor 5
0.0 [1..395] [1..385]
eIF5-PF, eIF5-PE... - The gene eIF5 is referred to in FlyBase by the symbol Dmel\eIF5 (CG9177, FBgn0030719). It is a prote...
gi|220953394, gi... - gi|220953394|gb|ACL89240.1| eIF5-PA [synthetic construct], gi|220943194|gb|ACL84140.1| eIF5-PA [synt...
0.0 [2..395] [3..408]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [1..395] [1..385]
gi|56207822, gi|... - gi|56207822|emb|CAI21349.1| novel protein (zgc:77026) [Danio rerio], gi|46403257|gb|AAS92648.1| euka...
0.0 [1..393] [1..376]
SPAC2F7.05c - translation initiation factor eIF5
IF5_SCHPO - Probable eukaryotic translation initiation factor 5 OS=Schizosaccharomyces pombe (strain 972 / ATCC ...
1.0E-94 [2..392] [3..374]

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Predicted Domain #1
Region A:
Residues: [1-95]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSINICRDNH DPFYRYKMPP IQAKVEGRGN GIKTAVLNVA DISHALNRPA PYIVKYFGFE  60
   61 LGAQTSISVD KDRYLVNGVH EPAKLQDVLD GFINK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.154902
Match: 1k8bA_
Description: Zinc-binding domain of translation initiation factor 2 beta
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [96-133]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FVLCGSCKNP ETEIIITKDN DLVRDCKACG KRTPMDLR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.09691
Match: 1k81A_
Description: Zinc-binding domain of translation initiation factor 2 beta
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [134-281]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HKLSSFILKN PPDSVSGSKK KKKAATASAN VRGGGLSISD IAQGKSQNAP SDGTGSSTPQ  60
   61 HHDEDEDELS RQIKAAASTL EDIEVKDDEW AVDMSEEAIR ARAKELEVNS ELTQLDEYGE 120
  121 WILEQAGEDK ENLPSDVELY KKAAELDV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [282-405]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNDPKIGCVL AQCLFDEDIV NEIAEHNAFF TKILVTPEYE KNFMGGIERF LGLEHKDLIP  60
   61 LLPKILVQLY NNDIISEEEI MRFGTKSSKK FVPKEVSKKV RRAAKPFITW LETAESDDDE 120
  121 EDDE

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 36.119186
Match: PF02020
Description: eIF4-gamma/eIF5/eIF2-epsilon

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle