YRC Public Data Repository - Protein Structure Prediction

Protein:	CLN2
Organism:	Saccharomyces cerevisiae
Length:	545 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CLN2.

Description	E-value	Query Range	Subject Range
CG12_YEAST - G1/S-specific cyclin CLN2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CLN2 PE=1 SV=2 CLN2 - G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S p...	0.0	[1..545]	[1..545]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	2.0E-86	[3..312]	[124..407]
gi\|7271222 - gi\|7271222\|emb\|CAB81558.1\| cyclin B1 [Nicotiana tabacum]	6.0E-86	[3..312]	[124..407]
gi\|1835260 - gi\|1835260\|emb\|CAA99990.1\| mitotic cyclin [Sesbania rostrata]	2.0E-83	[3..312]	[155..433]
CCNB1_SOYBN - G2/mitotic-specific cyclin S13-6 OS=Glycine max PE=2 SV=1	2.0E-82	[3..312]	[160..439]
gi\|6093215 - gi\|6093215\|emb\|CAB58998.1\| CYCB1-1 protein [Petunia x hybrida]	2.0E-82	[3..312]	[139..421]

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Predicted Domain #1

Region A:
Residues: [1-50]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASAEPRPRM GLVINAKPDY YPIELSNAEL LSHFEMLQEY HQEISTNVIA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [199-316]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INDYVLNVDE NCLMQYELYE NQVTYDKQCS EKRQSQLSQD SDATVDERPY QNEEEEEEDL  60
   61 KLKIKLINLK KFLIDVSAWQ YDLLRYELFE VSHGIFSIIN QFTNQDHGPF LMTPMTSE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	106.626727
Match:	1vin__
Description:	Cyclin A
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [51-198]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSCKFKPNPK LIDQQPEMNP VETRSNIITF LFELSVVTRV TNGIFFHSVR LYDRYCSKRI  60
   61 VLRDQAKLVV ATCLWLAAKT WGGCNHIINN VVIPTGGRFY GPNPRARIPR LSELVHYCGD 120
  121 GQVFDESMFL QMERHILDTL NWNIYEPM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	106.626727
Match:	1vin__
Description:	Cyclin A
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [317-545]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKNGEILSTL MNGIVSIPNS LMEVYKTVNG VLPFINQVKE YHLDLQRKLQ IASNLNISRK  60
   61 LTISTPSCSF ENSNSTSIPS PASSSQSHTP MRNMSSLSDN SVFSRNMEQS SPITPSMYQF 120
  121 GQQQSNSICG STVSVNSLVN TNNKQRIYEQ ITGPNSNNAT NDYIDLLNLN ESNKENQNPA 180
  181 TAHYLNGGPP KTSFINHGMF PSPTGTINSG KSSSASSLIS FGMGNTQVI

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits