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View Structure Prediction Details

Protein: GAL4
Organism: Saccharomyces cerevisiae
Length: 881 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GAL4.

Description E-value Query
Range
Subject
Range
GAL4 - DNA-binding transcription factor required for the activation of the GAL genes in response to galacto...
GAL4_YEAST - Regulatory protein GAL4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GAL4 PE=1 SV=2
gi|148353841 - gi|148353841|emb|CAN84669.1| yeast transcription factor [Transposon mutagenesis vector pMiET]
gi|183013543 - gi|183013543|gb|ACC38293.1| Gal4 [Cloning vector pBGT1]
gi|4995952 - gi|4995952|dbj|BAA78208.1| Gal4 [Dual-tagging gene trap vector pGT1]
gi|51036214 - gi|51036214|dbj|BAD35035.1| Gal4 [P1-specific P-element Gal4 driver pP{5'P1-Gal4-3'P1}]
gi|4995952|dbj|B... - Gal4 [Drosophila melanogaster], Gal4 OS=Dual-tagging gene trap vector pGT1 GN=Gal4 PE=4 SV=1
0.0 [1..881] [1..881]
gi|85081614 - gi|85081614|ref|XP_956755.1| hypothetical protein NCU01478 [Neurospora crassa OR74A]
gi|28917831, gi|... - gi|32414875|ref|XP_327917.1| hypothetical protein [Neurospora crassa], gi|28917831|gb|EAA27519.1| hy...
5.0E-86 [3..742] [61..810]
THI1_SCHPO - Thiamine repressible genes regulatory protein thi1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 2...
thi1 - transcription factor Thi1
3.0E-84 [4..752] [32..731]
SPBC530.08 - transcription factor
YN28_SCHPO - Uncharacterized transcriptional regulatory protein C530.08 OS=Schizosaccharomyces pombe (strain 972 ...
2.0E-83 [3..820] [23..807]
gi|1706176 - sp|P52958|CT1A_FUSSO CUTINASE TRANSCRIPTION FACTOR 1 ALPHA
CTF1A_FUSSO - Cutinase transcription factor 1 alpha OS=Fusarium solani subsp. pisi GN=CTF1-ALPHA PE=2 SV=1
8.0E-83 [3..822] [53..787]
gi|6901427 - gi|6901427|emb|CAB71797.1| pathway-specific nitrogen regulator [Tolypocladium inflatum]
3.0E-80 [2..821] [61..834]

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Predicted Domain #1
Region A:
Residues: [1-65]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLLSSIEQA CDICRLKKLK CSKEKPKCAK CLKNNWECRY SPKTKRSPLT RAHLTEVESR  60
   61 LERLE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 335.31133
Match: 1d66A_
Description: Gal4; CD2-Gal4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.56444258780502 bayes_pls_golite062009
DNA binding 4.26146437716972 bayes_pls_golite062009
nucleic acid binding 4.17369933547911 bayes_pls_golite062009
transcription factor activity 3.049435548132 bayes_pls_golite062009
sequence-specific DNA binding 2.98081393153291 bayes_pls_golite062009
binding 2.91929847152301 bayes_pls_golite062009
transcription activator activity 2.24483536326713 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.03201524223606 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.86200506906385 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [66-125]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLFLLIFPRE DLDMILKMDS LQDIKALLTG LFVQDNVNKD AVTDRLASVE TDMPLTLRQH  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 18.958607
Match: PF03902
Description: Gal4-like dimerisation domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.34861813464065 bayes_pls_golite062009
DNA binding 4.03985756894684 bayes_pls_golite062009
nucleic acid binding 3.97978190843512 bayes_pls_golite062009
transcription factor activity 2.87348461329489 bayes_pls_golite062009
binding 2.82809978070212 bayes_pls_golite062009
sequence-specific DNA binding 2.77469997789536 bayes_pls_golite062009
transcription activator activity 2.1512787242583 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.80191339934741 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.50774349911815 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [126-491]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RISATSSSEE SSNKGQRQLT VSIDSAAHHD NSTIPLDFMP RDALHGFDWS EEDDMSDGLP  60
   61 FLKTDPNNNG FFGDGSLLCI LRSIGFKPEN YTNSNVNRLP TMITDRYTLA SRSTTSRLLQ 120
  121 SYLNNFHPYC PIVHSPTLMM LYNNQIEIAS KDQWQILFNC ILAIGAWCIE GESTDIDVFY 180
  181 YQNAKSHLTS KVFESGSIIL VTALHLLSRY TQWRQKTNTS YNFHSFSIRM AISLGLNRDL 240
  241 PSSFSDSSIL EQRRRIWWSV YSWEIQLSLL YGRSIQLSQN TISFPSSVDD VQRTTTGPTI 300
  301 YHGIIETARL LQVFTKIYEL DKTVTAEKSP ICAKKCLMIC NEIEEVSRQA PKFLQMDIST 360
  361 TALTNL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [492-597]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKEHPWLSFT RFELKWKQLS LIIYVLRDFF TNFTQKKSQL EQDQNDHQSY EVKRCSIMLS  60
   61 DAAQRTVMSV SSYMDNHNVT PYFAWNCSYY LFNAVLVPIK TLLSNS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.875 0.004 galactose metabolic process f.18.1 F1F0 ATP synthase subunit A

Predicted Domain #5
Region A:
Residues: [598-881]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSNAENNETA QLLQQINTVL MLLKKLATFK IQTCEKYIQV LEEVCAPFLL SQCAIPLPHI  60
   61 SYNNSNGSAI KNIVGSATIA QYPTLPEENV NNISVKYVSP GSVGPSPVPL KSGASFSDLV 120
  121 KLLSNRPPSR NSPVTIPRST PSHRSVTPFL GQQQQLQSLV PLTPSALFGG ANFNQSGNIA 180
  181 DSSLSFTFTN SSNGPNLITT QTNSQALSQP IASSNVHDNF MNNEITASKI DDGNNSKPLS 240
  241 PGWTDQTAYN AFGITTGMFN TTTMDDVYNY LFDDEDTPPN PKKE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [655-778]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHISYNNSNG SAIKNIVGSA TIAQYPTLPE ENVNNISVKY VSPGSVGPSP VPLKSGASFS  60
   61 DLVKLLSNRP PSRNSPVTIP RSTPSHRSVT PFLGQQQQLQ SLVPLTPSAL FGGANFNQSG 120
  121 NIAD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [779-881]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSLSFTFTNS SNGPNLITTQ TNSQALSQPI ASSNVHDNFM NNEITASKID DGNNSKPLSP  60
   61 GWTDQTAYNA FGITTGMFNT TTMDDVYNYL FDDEDTPPNP KKE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle