YRC Public Data Repository - Protein Structure Prediction

Protein:	RBD2
Organism:	Saccharomyces cerevisiae
Length:	262 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RBD2.

Description	E-value	Query Range	Subject Range
RBD2 - Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p RBD2_YEAST - Rhomboid protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RBD2 PE=1 SV=1	6.0E-48	[1..262]	[1..262]
gi\|27468153, gi\|... - gi\|27468153\|ref\|NP_764790.1\| hypothetical protein SE1235 [Staphylococcus epidermidis ATCC 12228], gi... gi\|251810965, gi... - gi\|251810965\|ref\|ZP_04825438.1\| S54 family peptidase [Staphylococcus epidermidis BCM-HMP0060], gi\|25... gi\|57867074, gi\|... - gi\|57867074\|ref\|YP_188690.1\| rhomboid family protein [Staphylococcus epidermidis RP62A], gi\|57637732...	2.0E-34	[11..218]	[155..358]
gi\|25489851 - pir\|\|E83827 hypothetical protein BH1421 [imported] - Bacillus halodurans (strain C-125) gi\|15613984, gi\|... - gi\|15613984\|ref\|NP_242287.1\| hypothetical protein BH1421 [Bacillus halodurans C-125], gi\|10174038\|db...	2.0E-33	[7..217]	[180..388]
gi\|57651942, gi\|... - gi\|57651942\|ref\|YP_186446.1\| rhomboid family protein [Staphylococcus aureus subsp. aureus COL], gi\|5... gi\|160368587, gi... - gi\|161509778\|ref\|YP_001575437.1\| peptidase [Staphylococcus aureus subsp. aureus USA300_TCH1516], gi\|... gi\|227899939, gi... - gi\|227899939\|ref\|ZP_04017744.1\| S54 family peptidase [Staphylococcus aureus subsp. aureus TCH60], gi... gi\|255006335 - gi\|255006335\|ref\|ZP_05144936.2\| rhomboid family peptidase [Staphylococcus aureus subsp. aureus Mu50-... gi\|253314920 - gi\|253314920\|ref\|ZP_04838133.1\| rhomboid family peptidase [Staphylococcus aureus subsp. aureus str. ... gi\|87160848\|ref\|... - peptidase, rhomboid family [Staphylococcus aureus subsp. aureus USA300], peptidase, rhomboid family ... gi\|269203177\|ref... - rhomboid family protein [Staphylococcus aureus subsp. aureus ED98] gi\|15927129, gi\|... - gi\|15927129\|ref\|NP_374662.1\| hypothetical protein SA1379 [Staphylococcus aureus subsp. aureus N315],... gi\|87160848, gi\|... - gi\|87160848\|ref\|YP_494204.1\| rhomboid family peptidase [Staphylococcus aureus subsp. aureus USA300_F... gi\|25506799 - pir\|\|D89935 conserved hypothetical protein SA1379 [imported] - Staphylococcus aureus (strain N315) gi\|156979867, gi... - gi\|156979867\|ref\|YP_001442126.1\| hypothetical protein SAHV_1536 [Staphylococcus aureus subsp. aureus... gi\|15924539, gi\|... - gi\|15924539\|ref\|NP_372073.1\| hypothetical protein SAV1549 [Staphylococcus aureus subsp. aureus Mu50]... gi\|150374464, gi... - gi\|151221664\|ref\|YP_001332486.1\| peptidase, rhomboid family protein [Staphylococcus aureus subsp. au...	3.0E-32	[11..218]	[155..358]
gi\|253732202, gi... - gi\|253732202\|ref\|ZP_04866367.1\| S54 family peptidase [Staphylococcus aureus subsp. aureus USA300_TCH... gi\|49244828, gi\|... - gi\|49486385\|ref\|YP_043606.1\| hypothetical protein SAS1487 [Staphylococcus aureus subsp. aureus MSSA4... gi\|21204670, gi\|... - gi\|21283230\|ref\|NP_646318.1\| hypothetical protein MW1501 [Staphylococcus aureus subsp. aureus MW2], ... gi\|251814545, gi... - gi\|251814545\|ref\|ZP_04829018.1\| S54 family peptidase [Staphylococcus aureus subsp. aureus TCH70], gi...	3.0E-32	[11..218]	[155..358]
gi\|17431999 - gi\|17431999\|emb\|CAD18676.1\| probable membrane transmembrane protein [Ralstonia solanacearum GMI1000] gi\|17549744 - gi\|17549744\|ref\|NP_523084.1\| hypothetical protein RS04802 [Ralstonia solanacearum GMI1000]	7.0E-31	[13..206]	[203..403]
gi\|10438710 - gi\|10438710\|dbj\|BAB15318.1\| unnamed protein product [Homo sapiens]	9.0E-31	[46..196]	[646..789]
gi\|20071092, gi\|... - gi\|32306547\|ref\|NP_034247.1\| rhomboid family 1 [Mus musculus], gi\|20071092\|gb\|AAH27346.1\| Rhomboid f...	1.0E-30	[46..196]	[647..790]

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Predicted Domain #1

Region A:
Residues: [1-262]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNWKSYVFPG GHPPAALTTG LVVFLTAIYL LSFIFALRED LSLAPESLFK LQMSRLSLYP  60
   61 LIHLSLPHLL FNVLAIWAPL NLFEETHGTV YTGVFLNLSA LFAGILYCLL GKLLYPEALV 120
  121 AGASGWCFTL FAYYSFKESQ IRPRTRIFRT DYSIPTLYTP LVLLVAIAVV IPGSSFWGHF 180
  181 FGLCVGYAIG YKESWFNKIT PPGWIITKIE KSLDGLIRLI PWGIKYYRDE DIDRTKDYEP 240
  241 LMSTETPLPL HNDNSGTVLG TA

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	48.187087
Match:	PF01694
Description:	Rhomboid family

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
catalytic activity	0.545407789079971	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: