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View Structure Prediction Details

Protein: APL5
Organism: Saccharomyces cerevisiae
Length: 932 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APL5.

Description E-value Query
Range
Subject
Range
gi|151942604 - gi|151942604|gb|EDN60950.1| clathrin assembly complex AP-3 adaptin component delta-like subunit [Sac...
AP3D_YEAST - AP-3 complex subunit delta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=APL5 PE=1 SV=...
APL5 - Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport...
gi|190407766 - gi|190407766|gb|EDV11031.1| hypothetical protein SCRG_02302 [Saccharomyces cerevisiae RM11-1a]
0.0 [1..932] [1..932]
AP3D1_MOUSE - AP-3 complex subunit delta-1 OS=Mus musculus GN=Ap3d1 PE=1 SV=1
0.0 [19..899] [10..829]
gi|33869469 - gi|33869469|gb|AAH05142.1| AP3D1 protein [Homo sapiens]
0.0 [19..898] [10..832]
g-PB - The gene garnet is referred to in FlyBase by the symbol Dmel\g (CG10986, FBgn0001087). It is a prote...
0.0 [13..896] [5..866]
gi|71896545, gi|... - gi|71896545|ref|NP_776423.2| adaptor-related protein complex 3, delta 1 subunit [Bos taurus], gi|294...
0.0 [19..900] [6..830]

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Predicted Domain #1
Region A:
Residues: [1-94]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSLYAPGAE DIRQRLRPFG FFFEKSLKDL IKGIRSHNET PEKLDQFFKQ VLSECREEVN  60
   61 SPDLNSKTNA VLKLTYLEMY GFDMAWCNFH ILEV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 265.751666
Match: 1gw5A_
Description: Adaptin alpha C subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [95-266]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSNKLQQKR VGYLAASQSF YKDSDILMLA TNLLKKDLKY DGNNDVVKVG IALSGLSTII  60
   61 TPSLARDIAD DLFTMLNSTR PYIRKKAITA LFKVFLQYPE ALRDNFDKFV SKLDDDDISV 120
  121 VSAAVSVICE LSKKNPQPFI QLSPLLYEIL VTIDNNWIII RLLKLFTNLS QV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 71.30103
Match: 1b3uA_
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [267-330]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPKLRAKLLP KILELMESTV ATSVIYESVN CIVKGNMLEE DDFETAMACL ERLHTFCDSQ  60
   61 DPNL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 71.30103
Match: 1b3uA_
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [331-502]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RYISCILFYK IGKINTDFIS RFDQLIIRLL SDVDVSIRSK AIELVEGIVD EDNLKAIVQT  60
   61 LMKQFVDEDV VILQTGSIVY EKSKRIPIII PENYKIKMVN VIISICSADN YSSVNDFEWY 120
  121 NAVIMDLAML CQDISDKSLG SKIGEQFRNL MIKVPSMREV TIANIIKLIS ND

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 71.30103
Match: 1b3uA_
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [503-653]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NINKQLPTVL RECIWCLGEF STLVENGNDL IKIMTENISY YSHSVQEVLI LALVKVFSNW  60
   61 CNNFQEDKRF EIKMVLKELI EFFENLSYSS TFEVQERSVE VLEFLRLSLE ALEEDTEGLP 120
  121 MLLSEVLPSF FNAYELAPIA RGTQLKLAVD E

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 71.30103
Match: 1b3uA_
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [654-712]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLDLETPFLT KEAADELLDE QKSDAISDLM SDISMDEQVE LKFVDDSDTS YEEKEKLDD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.575 a.4.5 "Winged helix" DNA-binding domain
View Download 0.498 a.4.1 Homeodomain-like
View Download 0.406 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.528 a.112.1 Description not found.
View Download 0.437 a.4.1 Homeodomain-like
View Download 0.399 d.47.1 Ribosomal protein L11, N-terminal domain
View Download 0.364 a.4.5 "Winged helix" DNA-binding domain
View Download 0.351 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.343 a.4.1 Homeodomain-like
View Download 0.314 a.161.1 beta-catenin-interacting protein ICAT
View Download 0.299 a.64.2 Bacteriocin AS-48
View Download 0.296 a.65.1 Annexin
View Download 0.279 g.57.1 Serine proteinase inhibitor lekti
View Download 0.274 a.4.1 Homeodomain-like
View Download 0.270 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.269 d.58.7 RNA-binding domain, RBD
View Download 0.252 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.226 a.76.1 Iron-dependent represor protein, dimerization domain

Predicted Domain #7
Region A:
Residues: [713-932]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FENPFEIERE KERMSNPYYL GEEDEERTKN SKDLLDLNEE ESSDKKPETI RLNRTDNSLN  60
   61 SLSLSTTEIS RKKKKGKKKN RVQVLSDEPV IEAAPKRKDA FQKPHDNHST QNPLKKDKIN 120
  121 LRMHSQLENF DFSNFGQSSN AGRGSQEEGN LRKEDELELS RLEANLIVKD EKDNLSDTEE 180
  181 VIVIKKKKKG KKSKSKNKLK TKAKNSPEPN EFLRDQSTDI 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle