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View Structure Prediction Details

Protein: CDC60
Organism: Saccharomyces cerevisiae
Length: 1090 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CDC60.

Description E-value Query
Range
Subject
Range
SYLC_YEAST - Leucine--tRNA ligase, cytoplasmic OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC60 ...
CDC60 - Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.0 [1..1090] [1..1090]
SYLC_SCHPO - Putative leucine--tRNA ligase, cytoplasmic OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN...
SPAC26F1.13c - leucine-tRNA ligase
0.0 [2..1090] [15..1109]
gi|7243085 - gi|7243085|dbj|BAA92590.1| KIAA1352 protein [Homo sapiens]
0.0 [8..1084] [41..1113]
SYI_SHEON - Isoleucine--tRNA ligase OS=Shewanella oneidensis (strain MR-1) GN=ileS PE=3 SV=1
SO3532 - isoleucyl-tRNA synthetase
0.0 [5..990] [10..885]
gi|9858190 - gi|9858190|gb|AAG01037.1|AF293346_1 cytosolic leucyl-tRNA synthetase [Candida albicans]
0.0 [1..1090] [1..1096]
SYLC_MOUSE - Leucine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Lars PE=1 SV=2
0.0 [8..1084] [5..1079]
SYI_VIBVU - Isoleucine--tRNA ligase OS=Vibrio vulnificus (strain CMCP6) GN=ileS PE=3 SV=1
SYI_VIBVU - Isoleucine--tRNA ligase OS=Vibrio vulnificus GN=ileS PE=3 SV=1
0.0 [5..984] [10..887]

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Predicted Domain #1
Region A:
Residues: [1-8]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSGLVLE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [787-815]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEEITKESNL RTGEITDFFD IAFEHEMNA

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [841-862]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QAARDYYREA SGVMHKDLIA RY

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [901-912]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKPVDKGVLA AL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1ffyA_
Description: Isoleucyl-tRNA synthetase (IleRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [9-59]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTARRDALIA IEKKYQKIWA EEHQFEIDAP SIEDEPITMD SEELHRTYPK F

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [71-99]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VMHAGHCFTL SKVEFSIGFE RMNGKRALF

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [146-159]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDHEDVTKFK AKKS

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [720-786]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGHLMLNNSK MSKSTGNFMT LEQTVEKFGA DAARIAFADA GDTVEDANFD ESNANAAILR  60
   61 LFNLKEW

[Run NCBI BLAST on this sequence.]

Region E:
Residues: [816-840]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LIEKTYEQYA LTNYKNALKY GLFDF

[Run NCBI BLAST on this sequence.]

Region F:
Residues: [863-900]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IETQALLLAP IAPHFAEYIY REVLGNQTSV QNAKFPRA

[Run NCBI BLAST on this sequence.]

Region G:
Residues: [913-999]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DYLRNLQRSI REGEGQALKK KKGKSAEIDA SKPVKLTLLI SESFPEWQSQ CVEIVRKLFS  60
   61 EQTLDDNKKV REHIEPKEMK RAMPFIS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1ffyA_
Description: Isoleucyl-tRNA synthetase (IleRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [60-70]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSMAYPYMN G

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [100-145]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLGFHCTGMP ILACADKLKR EAELFGKNFD NVPAEEEEIK EETPAE

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [160-206]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KAAAKKGRGK YQFEIMLQLG IPREEIIKFA DAKYWLTYFP PLCESDC

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [545-719]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QWYVDYGEES WKKQAIECLE GMQLFAPEVK NAFEGVLDWL KNWAVCRTYG LGTRLPWDEK  60
   61 YLVESLSDST IYQSFYTIAH LLFKDYYGNE IGPLGISADQ MTDEVFDYIF QHQDDVKNTN 120
  121 IPLPALQKLR REFEYFYPLD VSISGKDLIP NHLTFFIYTH VALFPKKFWP KGIRA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1ffyA_
Description: Isoleucyl-tRNA synthetase (IleRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [207-544]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSLGARIDWR RSFVTTDANP YYDAFIRWQM NKLKAAGKIK FGERYTIYSE KDGQACMDHD  60
   61 RQSGEGVTPQ EYIGVKIEAL EFADDAAKII DSSSDLDKSK KFYFVAATLR PETMYGQTCC 120
  121 FVSPTIEYGI FDAGDSYFIT TERAFKNMSY QKLTPKRGFY KPIVTVPGKA FIGTKIHAPQ 180
  181 SVYPELRILP METVIATKGT GVVTCVPSNS PDDYITTKDL LHKPEYYGIK PEWIDHEIVP 240
  241 IMHTEKYGDL TAKAIVEEKK IQSPKDKNLL AEAKKIAYKE DYYTGTMIYG PYKGEKVEQA 300
  301 KNKVKADMIA AGEAFVYNEP ESQVMSRSGD DCIVSLED

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1ffyA_
Description: Isoleucyl-tRNA synthetase (IleRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [1000-1090]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLKQRLANEK PEDVFERELQ FSEIDTVKAA ARNVKKAAQA LKIAEFSAIS FPYGAKTGKD  60
   61 IFTGEEVEIP PVTKIVENAV PGNPGVVFQN I

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.688 0.568 leucine-tRNA ligase activity c.47.1 Thioredoxin-like
View Download 0.617 0.018 leucine-tRNA ligase activity d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.705 0.016 leucine-tRNA ligase activity c.84.1 Phosphoglucomutase, first 3 domains
View Download 0.592 0.013 leucine-tRNA ligase activity d.52.7 Ribosome-binding factor A, RbfA
View Download 0.553 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.553 N/A N/A d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.546 N/A N/A d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.539 N/A N/A d.58.14 Ribosomal protein S6
View Download 0.520 N/A N/A d.58.7 RNA-binding domain, RBD
View Download 0.518 N/A N/A d.58.41 SEA domain
View Download 0.505 N/A N/A c.103.1 Hypothetical protein MT938 (MTH938)
View Download 0.503 N/A N/A d.58.4 Dimeric alpha+beta barrel
View Download 0.488 N/A N/A d.120.1 Cytochrome b5
View Download 0.471 N/A N/A d.58.17 Metal-binding domain
View Download 0.466 N/A N/A b.1.1 Immunoglobulin
View Download 0.461 N/A N/A d.39.1 Dynein light chain 8 (DLC8)
View Download 0.460 N/A N/A d.57.1 DNA damage-inducible protein DinI
View Download 0.460 N/A N/A d.65.1 Hedgehog/DD-pepidase
View Download 0.452 N/A N/A a.74.1 Cyclin-like
View Download 0.437 N/A N/A g.10.1 Hairpin loop containing domain-like
View Download 0.435 N/A N/A d.95.2 Homing endonucleases
View Download 0.431 N/A N/A d.130.1 S-adenosylmethionine synthetase
View Download 0.428 N/A N/A a.39.1 EF-hand
View Download 0.416 N/A N/A d.52.4 YhbC-like, N-terminal domain
View Download 0.414 N/A N/A d.58.2 Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain
View Download 0.407 N/A N/A d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.402 N/A N/A d.58.11 EF-G/eEF-2 domains III and V
View Download 0.394 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.393 N/A N/A c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.386 N/A N/A d.58.17 Metal-binding domain
View Download 0.377 N/A N/A a.74.1 Cyclin-like
View Download 0.376 N/A N/A a.74.1 Cyclin-like
View Download 0.373 N/A N/A d.74.1 Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
View Download 0.373 N/A N/A d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.366 N/A N/A d.58.8 Viral DNA-binding domain
View Download 0.356 N/A N/A d.74.5 Hypothetical protein Yml108w
View Download 0.354 N/A N/A d.52.2 GMP synthetase C-terminal dimerisation domain
View Download 0.348 N/A N/A d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.344 N/A N/A b.43.4 Riboflavin synthase domain-like
View Download 0.342 N/A N/A d.58.12 eEF-1beta-like
View Download 0.342 N/A N/A b.36.1 PDZ domain-like
View Download 0.333 N/A N/A d.52.6 BolA-like
View Download 0.330 N/A N/A a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.320 N/A N/A d.58.7 RNA-binding domain, RBD
View Download 0.314 N/A N/A a.71.2 Helical domain of Sec23/24
View Download 0.314 N/A N/A d.58.5 GlnB-like
View Download 0.309 N/A N/A b.43.4 Riboflavin synthase domain-like
View Download 0.305 N/A N/A d.52.1 Alpha-lytic protease prodomain
View Download 0.294 N/A N/A d.130.1 S-adenosylmethionine synthetase
View Download 0.291 N/A N/A d.56.1 GroEL-intermediate domain like
View Download 0.288 N/A N/A d.74.3 RBP11-like subunits of RNA polymerase
View Download 0.286 N/A N/A a.51.1 Cytochrome c oxidase subunit h
View Download 0.283 N/A N/A d.74.3 RBP11-like subunits of RNA polymerase
View Download 0.283 N/A N/A d.17.4 NTF2-like
View Download 0.282 N/A N/A b.1.18 E set domains
View Download 0.280 N/A N/A d.29.1 Ribosomal protein L31e
View Download 0.273 N/A N/A d.58.3 Protease propeptides/inhibitors
View Download 0.260 N/A N/A c.47.1 Thioredoxin-like
View Download 0.258 N/A N/A d.74.4 Prokaryotic AspRS, insert domain
View Download 0.257 N/A N/A d.12.1 Ribosomal proteins L23 and L15e
View Download 0.253 N/A N/A d.58.42 N-utilization substance G protein NusG, N-terminal domain
View Download 0.251 N/A N/A a.55.1 IHF-like DNA-binding proteins
View Download 0.248 N/A N/A a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.246 N/A N/A d.13.1 HIT-like
View Download 0.244 N/A N/A d.202.1 Transcription factor NusA, N-terminal domain
View Download 0.242 N/A N/A d.58.35 Pseudouridine synthase
View Download 0.242 N/A N/A d.53.1 Ribosomal protein S3 C-terminal domain
View Download 0.237 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.236 N/A N/A a.60.8 HRDC-like
View Download 0.235 N/A N/A a.60.1 SAM/Pointed domain
View Download 0.231 N/A N/A a.58.1 Chemotaxis receptor methyltransferase CheR, N-terminal domain
View Download 0.228 N/A N/A a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.213 N/A N/A d.58.11 EF-G/eEF-2 domains III and V
View Download 0.209 N/A N/A d.227.1 OsmC-like
View Download 0.203 N/A N/A d.55.1 Ribosomal protein L22
View Download 0.202 N/A N/A d.89.1 Origin of replication-binding domain, RBD-like
View Download 0.201 N/A N/A c.47.1 Thioredoxin-like
View Download 0.200 N/A N/A a.1.1 Globin-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle