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View Structure Prediction Details

Protein: PEP4
Organism: Saccharomyces cerevisiae
Length: 405 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PEP4.

Description E-value Query
Range
Subject
Range
PEPA_CANLF - Pepsin A OS=Canis lupus familiaris GN=PGA PE=2 SV=1
0.0 [4..403] [1..384]
gi|164604 - gi|164604|gb|AAA31096.1| pepsinogen A precursor
0.0 [4..403] [1..383]
PEPA_SUNMU - Pepsin A OS=Suncus murinus GN=PGA PE=1 SV=2
0.0 [4..403] [2..385]
gi|23943854, gi|... - gi|23943854|ref|NP_055039.1| pepsinogen 5, group I [Homo sapiens], gi|223461673|gb|AAI47000.1| Pepsi...
0.0 [4..403] [1..386]
gi|27503926, gi|... - gi|94733050|emb|CAK04171.1| cathepsin D [Danio rerio], gi|68389560|ref|XP_686813.1| PREDICTED: simil...
0.0 [4..404] [1..395]
gi|28603728, gi|... - gi|6224889|gb|AAF05999.1|AF192333_1 pregnancy-associated glycoprotein-16 [Bos taurus], gi|28603728|r...
0.0 [4..405] [1..380]
PEPA_RHIFE - Pepsin A OS=Rhinolophus ferrumequinum GN=PGA PE=2 SV=1
0.0 [4..403] [1..384]

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Predicted Domain #1
Region A:
Residues: [1-74]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSLKALLPL ALLLVSANQV AAKVHKAKIY KHELSDEMKE VTFEQHLAHL GQKYLTQFEK  60
   61 ANPEVVFSRE HPFF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.887 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region

Predicted functions:

Term Confidence Notes
aspartic-type endopeptidase activity 7.9145950161796 bayes_pls_golite062009
aspartic-type peptidase activity 7.9145950161796 bayes_pls_golite062009
peptidase activity 5.78181196721293 bayes_pls_golite062009
endopeptidase activity 5.4888481808613 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 5.39972232367526 bayes_pls_golite062009
hydrolase activity 4.34796304893506 bayes_pls_golite062009
catalytic activity 1.54514410489082 bayes_pls_golite062009
binding 1.10054369202721 bayes_pls_golite062009
receptor binding 0.561225023505917 bayes_pls_golite062009
protein binding 0.193907750061394 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [75-91]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TEGGHDVPLT NYLNAQY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [225-405]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKRFAFYLGD TSKDTENGGE ATFGGIDESK FKGDITWLPV RRKAYWEVKF EGIGLGDEYA  60
   61 ELESHGAAID TGTSLITLPS GLAEMINAEI GAKKGWTGQY TLDCNTRDNL PDLIFNFNGY 120
  121 NFTIGPYDYT LEVSGSCISA ITPMDFPEPV GPLAIVGDAF LRKYYSIYDL GNNAVGLAKA 180
  181 I

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10123.0
Match: 1dp5A_
Description: Acid protease
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [92-224]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTDITLGTPP QNFKVILDTG SSNLWVPSNE CGSLACFLHS KYDHEASSSY KANGTEFAIQ  60
   61 YGTGSLEGYI SQDTLSIGDL TIPKQDFAEA TSEPGLTFAF GKFDGILGLG YDTISVDKVV 120
  121 PPFYNAIQQD LLD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10123.0
Match: 1dp5A_
Description: Acid protease
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle