YRC Public Data Repository - Protein Structure Prediction

Protein:	ATG5
Organism:	Saccharomyces cerevisiae
Length:	294 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ATG5.

Description	E-value	Query Range	Subject Range
ATG5_YEAST - Autophagy protein 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ATG5 PE=1 SV=1 gi\|190407812 - gi\|190407812\|gb\|EDV11077.1\| autophagy protein 5 [Saccharomyces cerevisiae RM11-1a] gi\|207340633 - gi\|207340633\|gb\|EDZ68925.1\| YPL149Wp-like protein [Saccharomyces cerevisiae AWRI1631] ATG5 - Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to fo...	0.0	[1..294]	[1..294]
ATG5 - ATG5 autophagy related 5 homolog (S. cerevisiae) gi\|55627156, gi\|... - gi\|55627156\|ref\|XP_518659.1\| PREDICTED: hypothetical protein LOC462905 isoform 4 [Pan troglodytes], ... gi\|109072199, gi... - gi\|109072201\|ref\|XP_001088300.1\| PREDICTED: APG5 autophagy 5-like isoform 4 [Macaca mulatta], gi\|109...	0.0	[3..283]	[6..271]
ATG5_MOUSE - Autophagy protein 5 OS=Mus musculus GN=Atg5 PE=1 SV=1	2.0E-99	[3..283]	[6..271]
Atg5-PA - The gene Autophagy-specific gene 5 is referred to in FlyBase by the symbol Dmel\Atg5 (CG1643, FBgn00... gi\|220956516, gi... - gi\|220956516\|gb\|ACL90801.1\| Atg5-PA [synthetic construct], gi\|220946960\|gb\|ACL86023.1\| Atg5-PA [synt...	1.0E-79	[3..281]	[6..264]
ATG5_SCHPO - Autophagy protein 5 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=atg5 PE=1 SV=1 mug77 - autophagy associated protein Atg5	3.0E-70	[3..284]	[9..261]
ATG5_ARATH - Autophagy protein 5 OS=Arabidopsis thaliana GN=ATG5 PE=2 SV=1	3.0E-66	[8..282]	[9..331]
CE27025 - WBGene00022152 status:Partially_confirmed TR:Q95XN4 protein_id:AAK73911.1	1.0E-51	[3..206]	[4..189]
gi\|85092056 - gi\|85092056\|ref\|XP_959205.1\| hypothetical protein [Neurospora crassa OR74A] ATG5_NEUCR - Autophagy protein 5 - Neurospora crassa	2.0E-38	[4..282]	[165..395]

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Predicted Domain #1

Region A:
Residues: [1-196]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDIKQLLWN GELNVLVSID PSFLMKGSPR EIAVLRIRVP RETYLVNYMP LIWNKIKSFL  60
   61 SFDPLTDSEK YFWFEHNKTP IPWNYPVGVL FDCLAGKSAT FTTSFENQVK DVLTFLRIHL 120
  121 VMGDSLPPTI IPIASSKTQA EKFWFHQWKQ VCFILNGSSK AIMSLSVNEA RKFWGSVITR 180
  181 NFQDFIEISN KISSSR

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [197-294]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRHIPLIIQT SRTSGTFRIS QPTISMTGVN PTLKDIEGDI LDVKEGINGN DVMVICQGIE  60
   61 IPWHMLLYDL YSKLRSFDGF LYITLVPIKG GDKASSEL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.499	0.038	protein targeting to vacuole	d.79.1	YjgF-like
View	Download	0.595	0.016	protein targeting to vacuole	d.68.3	SirA-like
View	Download	0.728	0.015	protein targeting to vacuole	d.68.1	Translation initiation factor IF3, C-terminal domain
View	Download	0.501	0.007	protein targeting to vacuole	c.13.2	Anti-sigma factor antagonist SpoIIaa
View	Download	0.515	N/A	N/A	d.79.2	Tubulin/Dihydroxyacetone kinase C-terminal domain
View	Download	0.481	N/A	N/A	c.23.1	CheY-like
View	Download	0.462	N/A	N/A	c.97.1	Cytidine deaminase-like
View	Download	0.459	N/A	N/A	c.53.1	Resolvase-like
View	Download	0.457	N/A	N/A	c.102.1	Cell-division inhibitor MinC, N-terminal domain
View	Download	0.451	N/A	N/A	d.58.44	Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View	Download	0.428	N/A	N/A	d.34.1	DNA-binding domain of Mlu1-box binding protein MBP1
View	Download	0.424	N/A	N/A	a.165.1	Myosin phosphatase inhibitor 17kDa protein, CPI-17
View	Download	0.412	N/A	N/A	c.3.1	FAD/NAD(P)-binding domain
View	Download	0.410	N/A	N/A	c.95.1	Thiolase-like
View	Download	0.390	N/A	N/A	c.10.1	RNI-like
View	Download	0.379	N/A	N/A	d.68.4	YhbY-like
View	Download	0.375	N/A	N/A	c.37.1	P-loop containing nucleoside triphosphate hydrolases
View	Download	0.369	N/A	N/A	c.45.1	(Phosphotyrosine protein) phosphatases II
View	Download	0.348	N/A	N/A	c.2.1	NAD(P)-binding Rossmann-fold domains
View	Download	0.346	N/A	N/A	a.158.1	F-box domain
View	Download	0.346	N/A	N/A	c.23.12	Formate/glycerate dehydrogenase catalytic domain-like
View	Download	0.339	N/A	N/A	a.112.1	Description not found.
View	Download	0.338	N/A	N/A	d.58.14	Ribosomal protein S6
View	Download	0.337	N/A	N/A	b.1.2	Fibronectin type III
View	Download	0.334	N/A	N/A	d.16.1	FAD-linked reductases, C-terminal domain
View	Download	0.323	N/A	N/A	d.109.1	Actin depolymerizing proteins
View	Download	0.311	N/A	N/A	d.58.18	Regulatory domain in the aminoacid metabolism
View	Download	0.308	N/A	N/A	c.26.1	Nucleotidylyl transferase
View	Download	0.308	N/A	N/A	c.48.1	TK C-terminal domain-like
View	Download	0.297	N/A	N/A	d.80.1	Tautomerase/MIF
View	Download	0.289	N/A	N/A	b.34.8	Fumarylacetoacetate hydrolase, FAH, N-terminal domain
View	Download	0.283	N/A	N/A	c.59.1	MurD-like peptide ligases, peptide-binding domain
View	Download	0.260	N/A	N/A	c.52.1	Restriction endonuclease-like
View	Download	0.256	N/A	N/A	d.16.1	FAD-linked reductases, C-terminal domain
View	Download	0.251	N/A	N/A	c.47.1	Thioredoxin-like
View	Download	0.247	N/A	N/A	c.59.1	MurD-like peptide ligases, peptide-binding domain
View	Download	0.244	N/A	N/A	c.121.1	Ribose/Galactose isomerase RpiB/AlsB
View	Download	0.238	N/A	N/A	a.40.1	Calponin-homology domain, CH-domain
View	Download	0.237	N/A	N/A	d.208.1	MTH1598-like
View	Download	0.234	N/A	N/A	c.20.1	Initiation factor IF2/eIF5b, domain 3
View	Download	0.232	N/A	N/A	c.55.1	Actin-like ATPase domain
View	Download	0.228	N/A	N/A	d.175.1	Penicillin binding protein dimerisation domain
View	Download	0.221	N/A	N/A	c.23.3	Hypothetical protein MTH538
View	Download	0.221	N/A	N/A	c.23.6	Cobalamin (vitamin B12)-binding domain
View	Download	0.219	N/A	N/A	c.58.1	Aminoacid dehydrogenase-like, N-terminal domain
View	Download	0.217	N/A	N/A	c.84.1	Phosphoglucomutase, first 3 domains
View	Download	0.216	N/A	N/A	d.108.1	Acyl-CoA N-acyltransferases (Nat)
View	Download	0.215	N/A	N/A	d.54.1	Enolase N-terminal domain-like
View	Download	0.214	N/A	N/A	d.15.1	Ubiquitin-like
View	Download	0.213	N/A	N/A	c.37.1	P-loop containing nucleoside triphosphate hydrolases
View	Download	0.209	N/A	N/A	d.108.1	Acyl-CoA N-acyltransferases (Nat)
View	Download	0.206	N/A	N/A	c.55.4	Translational machinery components
View	Download	0.202	N/A	N/A	c.46.1	Rhodanese/Cell cycle control phosphatase

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits