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View Structure Prediction Details

Protein: TBF1
Organism: Saccharomyces cerevisiae
Length: 562 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TBF1.

Description E-value Query
Range
Subject
Range
gi|4604 - gi|4604|emb|CAA49191.1| TBF1 protein [Saccharomyces cerevisiae]
0.0 [1..562] [1..562]
trf1 - telomeric DNA binding factor Trf1
TRF1_SCHPO - Telomeric DNA-binding factor trf1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=trf1 PE=...
0.0 [42..487] [95..484]
gi|6474760 - gi|6474760|dbj|BAA87294.1| Hypothetical nuclear protein [Schizosaccharomyces pombe]
1.0E-77 [143..372] [1..195]
gi|85082158 - gi|85082158|ref|XP_956863.1| hypothetical protein NCU03416 [Neurospora crassa OR74A]
gi|32404122, gi|... - gi|32404122|ref|XP_322674.1| hypothetical protein [Neurospora crassa], gi|28917942|gb|EAA27627.1| pr...
7.0E-35 [362..486] [682..793]

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Predicted Domain #1
Region A:
Residues: [1-112]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSQVPNNNE SLNRFNDIIQ SLPARTRLTI CSLCLLDNIS TQLLRFLILN ANSPNIIAVL  60
   61 TDQTAFLSSG ETEIFQTLVK LFKQIRMIYH TRSPLLSVHD VAPGLWFPNS PP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.852 0.421 nuclear chromosome, telomeric region a.1.1 Globin-like
View Download 0.750 0.421 nuclear chromosome, telomeric region a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.773 0.421 nuclear chromosome, telomeric region a.60.2 RuvA domain 2-like
View Download 0.744 0.421 nuclear chromosome, telomeric region a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.852 0.421 nuclear chromosome, telomeric region a.1.1 Globin-like
View Download 0.773 0.421 nuclear chromosome, telomeric region a.60.2 RuvA domain 2-like
View Download 0.750 0.421 nuclear chromosome, telomeric region a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.744 0.421 nuclear chromosome, telomeric region a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.697 0.421 nuclear chromosome, telomeric region a.1.1 Globin-like
View Download 0.697 0.421 nuclear chromosome, telomeric region a.1.1 Globin-like
View Download 0.600 0.421 nuclear chromosome, telomeric region a.24.17 Group V grass pollen allergen
View Download 0.597 0.421 nuclear chromosome, telomeric region a.39.1 EF-hand
View Download 0.574 0.421 nuclear chromosome, telomeric region a.4.3 ARID-like
View Download 0.556 0.421 nuclear chromosome, telomeric region a.60.9 lambda integrase-like, N-terminal domain
View Download 0.554 0.421 nuclear chromosome, telomeric region a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.497 0.421 nuclear chromosome, telomeric region a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.496 0.421 nuclear chromosome, telomeric region a.4.5 "Winged helix" DNA-binding domain
View Download 0.493 0.421 nuclear chromosome, telomeric region d.52.7 Ribosome-binding factor A, RbfA
View Download 0.489 0.421 nuclear chromosome, telomeric region d.188.1 Prokaryotic ribosomal protein L17
View Download 0.464 0.421 nuclear chromosome, telomeric region d.110.4 SNARE-like
View Download 0.453 0.421 nuclear chromosome, telomeric region a.74.1 Cyclin-like
View Download 0.448 0.421 nuclear chromosome, telomeric region a.64.1 Saposin
View Download 0.442 0.421 nuclear chromosome, telomeric region a.158.1 F-box domain
View Download 0.438 0.421 nuclear chromosome, telomeric region d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.437 0.421 nuclear chromosome, telomeric region a.29.2 Bromodomain
View Download 0.432 0.421 nuclear chromosome, telomeric region c.48.1 TK C-terminal domain-like
View Download 0.429 0.421 nuclear chromosome, telomeric region a.118.8 TPR-like
View Download 0.428 0.421 nuclear chromosome, telomeric region d.201.1 SRP19
View Download 0.419 0.421 nuclear chromosome, telomeric region a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.419 0.421 nuclear chromosome, telomeric region a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.415 0.421 nuclear chromosome, telomeric region c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.407 0.421 nuclear chromosome, telomeric region a.7.6 Ribosomal protein S20
View Download 0.403 0.421 nuclear chromosome, telomeric region d.129.2 Phosphoglucomutase, C-terminal domain
View Download 0.396 0.421 nuclear chromosome, telomeric region b.118.1 FAS1 domain
View Download 0.390 0.421 nuclear chromosome, telomeric region a.1.1 Globin-like
View Download 0.380 0.421 nuclear chromosome, telomeric region a.1.1 Globin-like
View Download 0.371 0.421 nuclear chromosome, telomeric region a.29.2 Bromodomain
View Download 0.354 0.421 nuclear chromosome, telomeric region a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.354 0.421 nuclear chromosome, telomeric region a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.346 0.421 nuclear chromosome, telomeric region a.74.1 Cyclin-like
View Download 0.338 0.421 nuclear chromosome, telomeric region a.49.1 C-terminal domain of B transposition protein
View Download 0.337 0.421 nuclear chromosome, telomeric region a.156.1 S13-like H2TH domain
View Download 0.332 0.421 nuclear chromosome, telomeric region d.118.1 N-acetylmuramoyl-L-alanine amidase-like
View Download 0.330 0.421 nuclear chromosome, telomeric region a.24.3 Cytochromes
View Download 0.328 0.421 nuclear chromosome, telomeric region a.24.4 Hemerythrin
View Download 0.327 0.421 nuclear chromosome, telomeric region a.66.1 Transducin (alpha subunit), insertion domain
View Download 0.321 0.421 nuclear chromosome, telomeric region a.74.1 Cyclin-like
View Download 0.316 0.421 nuclear chromosome, telomeric region a.4.1 Homeodomain-like
View Download 0.310 0.421 nuclear chromosome, telomeric region c.23.1 CheY-like
View Download 0.308 0.421 nuclear chromosome, telomeric region f.1.1 Colicin
View Download 0.303 0.421 nuclear chromosome, telomeric region a.26.1 4-helical cytokines
View Download 0.302 0.421 nuclear chromosome, telomeric region a.77.1 DEATH domain
View Download 0.298 0.421 nuclear chromosome, telomeric region a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.296 0.421 nuclear chromosome, telomeric region a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.291 0.421 nuclear chromosome, telomeric region a.29.2 Bromodomain
View Download 0.284 0.421 nuclear chromosome, telomeric region d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.281 0.421 nuclear chromosome, telomeric region a.77.1 DEATH domain
View Download 0.277 0.421 nuclear chromosome, telomeric region a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.272 0.421 nuclear chromosome, telomeric region a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.268 0.421 nuclear chromosome, telomeric region f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.268 0.421 nuclear chromosome, telomeric region a.4.3 ARID-like
View Download 0.266 0.421 nuclear chromosome, telomeric region a.4.1 Homeodomain-like
View Download 0.265 0.421 nuclear chromosome, telomeric region f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.259 0.421 nuclear chromosome, telomeric region a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.258 0.421 nuclear chromosome, telomeric region d.150.1 4'-phosphopantetheinyl transferase
View Download 0.255 0.421 nuclear chromosome, telomeric region f.14.1 Voltage-gated potassium channels
View Download 0.255 0.421 nuclear chromosome, telomeric region f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.250 0.421 nuclear chromosome, telomeric region a.4.12 TrpR-like
View Download 0.248 0.421 nuclear chromosome, telomeric region a.118.14 FliG
View Download 0.248 0.421 nuclear chromosome, telomeric region a.40.1 Calponin-homology domain, CH-domain
View Download 0.245 0.421 nuclear chromosome, telomeric region a.4.5 "Winged helix" DNA-binding domain
View Download 0.243 0.421 nuclear chromosome, telomeric region d.52.4 YhbC-like, N-terminal domain
View Download 0.242 0.421 nuclear chromosome, telomeric region a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.238 0.421 nuclear chromosome, telomeric region a.46.1 Methionine synthase domain
View Download 0.236 0.421 nuclear chromosome, telomeric region a.4.5 "Winged helix" DNA-binding domain
View Download 0.231 0.421 nuclear chromosome, telomeric region f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.231 0.421 nuclear chromosome, telomeric region d.21.1 Diaminopimelate epimerase-like
View Download 0.230 0.421 nuclear chromosome, telomeric region a.54.1 Domain of early E2A DNA-binding protein, ADDBP
View Download 0.228 0.421 nuclear chromosome, telomeric region a.61.1 Retroviral matrix proteins
View Download 0.221 0.421 nuclear chromosome, telomeric region a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.215 0.421 nuclear chromosome, telomeric region i.11.1 Computational models partly based on NMR data
View Download 0.212 0.421 nuclear chromosome, telomeric region a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.211 0.421 nuclear chromosome, telomeric region a.85.1 Hemocyanin, N-terminal domain
View Download 0.208 0.421 nuclear chromosome, telomeric region a.2.3 Chaperone J-domain
View Download 0.202 0.421 nuclear chromosome, telomeric region a.25.1 Ferritin-like
View Download 0.201 0.421 nuclear chromosome, telomeric region d.16.1 FAD-linked reductases, C-terminal domain

Predicted Domain #2
Region A:
Residues: [113-384]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLILRGHEAF IITAIRKANL LTFLLTSLNC LNYGFELLQS IFLDIFCPNT NTVGNNSLEQ  60
   61 SGKFLKSQAI LYLDLKTQAY IAGLKEFQDE TNEISLEKKQ ELLDLIFPSN LADILVQRRT 120
  121 GDSGDITLLT PSEKDFVERC DRRRENLKIV QDFNSLTQSY EWAQFIRELL DYCNKNMGLI 180
  181 IWGRKGRGKS PLYDFDVNEF DPQVLFSTGT RTVEFMDDQN QPSSASAFLS TARPNHYSTH 240
  241 TPTTDVSSKN PAITQSIVDA AVAASMSNSS SG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.575 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.544 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.508 N/A N/A c.52.1 Restriction endonuclease-like
View Download 0.495 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.483 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain

Predicted Domain #3
Region A:
Residues: [385-497]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHSSHNNSSN SNNNGSIGLR KPKAKRTWSK EEEEALVEGL KEVGPSWSKI LDLYGPGGKI  60
   61 TENLKNRTQV QLKDKARNWK LQYLKSGKPL PDYLIKVTGN LEKIYKAKKK FSQ

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 10.920819
Match: PF00249
Description: Myb-like DNA-binding domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [498-562]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPNSSTIMEQ NLSQHPSSAA SATEDTQTHQ EDSHGQNSDN MPSNGLFGNS TSDNTGFDPH  60
   61 LEDGM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.306 0.908 nuclear chromosome, telomeric region a.4.1 Homeodomain-like
View Download 0.301 0.908 nuclear chromosome, telomeric region c.47.1 Thioredoxin-like
View Download 0.276 0.908 nuclear chromosome, telomeric region a.2.3 Chaperone J-domain
View Download 0.390 0.908 nuclear chromosome, telomeric region a.159.1 Protein serine/threonine phosphatase 2C, C-terminal domain
View Download 0.309 0.908 nuclear chromosome, telomeric region a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.272 0.908 nuclear chromosome, telomeric region a.36.1 Signal peptide-binding domain
View Download 0.263 0.908 nuclear chromosome, telomeric region a.60.1 SAM/Pointed domain
View Download 0.247 0.908 nuclear chromosome, telomeric region a.60.2 RuvA domain 2-like
View Download 0.237 0.908 nuclear chromosome, telomeric region a.28.2 Colicin E immunity proteins


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle