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View Structure Prediction Details

Protein: HHO1
Organism: Saccharomyces cerevisiae
Length: 258 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HHO1.

Description E-value Query
Range
Subject
Range
gi|32480770 - gi|32480770|gb|AAO26655.1| SNF2 histone linker PHD RING helicase isoform B [Mus musculus]
2.0E-24 [38..199] [163..319]
gi|190407831 - gi|190407831|gb|EDV11096.1| histone H1 [Saccharomyces cerevisiae RM11-1a]
HHO1 - Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA r...
H1_YEAST - Histone H1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HHO1 PE=1 SV=1
2.0E-23 [1..258] [1..258]
gi|27436873, gi|... - gi|27436873|ref|NP_775105.1| SNF2 histone linker PHD RING helicase isoform b [Homo sapiens], gi|2736...
9.0E-23 [38..164] [433..556]

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Predicted Domain #1
Region A:
Residues: [1-142]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPKKSTTKT TSKGKKPATS KGKEKSTSKA AIKKTTAKKE EASSKSYREL IIEGLTALKE  60
   61 RKGSSRPALK KFIKENYPIV GSASNFDLYF NNAIKKGVEA GDFEQPKGPA GAVKLAKKKS 120
  121 PEVKKEKEVS PKPKQAATSV SA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.0
Match: 1hstA_
Description: Histone H5, globular domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.835523092977445 bayes_pls_golite062009
transcription regulator activity 0.4843036104266 bayes_pls_golite062009
nucleic acid binding 0.37117756729668 bayes_pls_golite062009
DNA binding 0.3118855114645 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [143-258]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TASKAKAAST KLAPKKVVKK KSPTVTAKKA SSPSSLTYKE MILKSMPQLN DGKGSSRIVL  60
   61 KKYVKDTFSS KLKTSSNFDY LFNSAIKKCV ENGELVQPKG PSGIIKLNKK KVKLST

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 0.835523092977445 bayes_pls_golite062009
transcription regulator activity 0.4843036104266 bayes_pls_golite062009
nucleic acid binding 0.37117756729668 bayes_pls_golite062009
DNA binding 0.3118855114645 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle