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View Structure Prediction Details

Protein: GDE1
Organism: Saccharomyces cerevisiae
Length: 1223 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GDE1.

Description E-value Query
Range
Subject
Range
GDE1_YEAST - Glycerophosphodiester phosphodiesterase GDE1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c...
GDE1 - Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphospha...
0.0 [1..1223] [1..1223]
ANK2 - ankyrin 2, neuronal
0.0 [49..875] [4..814]
gi|710552|gb|AAB... - ankyrin 3 [Mus musculus]
gi|11276935, gi|... - gi|710552|gb|AAB01607.1| ankyrin 3 [Mus musculus domesticus], gi|22129770|ref|NP_666117.1| ankyrin 3...
0.0 [72..911] [20..835]
gi|3885972 - gi|3885972|gb|AAC78143.1| 270 kDa ankyrin G isoform [Rattus norvegicus]
0.0 [31..910] [2..859]

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Predicted Domain #1
Region A:
Residues: [1-202]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFGKTFANH RIPEWSSQYV GYKSLKKMIK EITRLQEDIY RAHNKNSYDE GRPPTKMRDS  60
   61 SNSAQNYLDS PKIQKLLASF FFAVDRDIEK VDTFYNSQYA EYKKRFERLL SSNQFNEIKS 120
  121 TLVVDANKED AVAQTLLTKD TREMNMLLKG TSQASRLSYH KDDLIEIQSI LAELRKQFRN 180
  181 LKWYAELNKR AFGKILKKLD KK

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 50.102373
Match: PF03105
Description: SPX domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [203-262]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGTNQQMSTM KTRILPLQFA NDSLITKDLS LLKTIWEQVT FRINSYERVM RSTSPNANAN  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [263-366]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNTEFFKIIC VFIEEDDSKG LIRELTNLYS ELSLIPTRIM ISVLNKAALS KSLACIDAIL  60
   61 KVIPSLNDSE DINRRNFFHH HIIAIGKLIR KQEILSRKKK SQPS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 177.045757
Match: 1n11A_
Description: Ankyrin-R
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
structural molecule activity 2.22255916855045 bayes_pls_golite062009
binding 1.62593430784178 bayes_pls_golite062009
protein binding 1.39636607384619 bayes_pls_golite062009
calcium-independent phospholipase A2 activity 0.621306773219824 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [367-499]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KYTNSEGEIV TDLRTLHTTL SAPAESDSIT EEEKSSACTL SYILEELPIH LRPCLFQHDN  60
   61 YKRTPLHYSC QYGLSEVTKL IIKLMKEWNI WNEIPIDDVS AFGDAESLTP LHLCVLGAHP 120
  121 KTTEVLLQSL DPN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [516-527]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NYPLLHVLLS SK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 177.045757
Match: 1n11A_
Description: Ankyrin-R
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [500-515]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VKLKSSSLLH LATEWN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [528-680]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RFDINYQDNE LHETPLYLAC RLNFFEAAVC LLYNGADLEI REKLFGWTAI FVAAAEGFTD  60
   61 IVKLLIANNA NFDIEDEGGW TPMEHAVLRG HLHIADMVQI RDELVTHPHS QLNSGSEEKE 120
  121 PLNEISAGEL NERNENGNGG NKGSLGKLAG PIK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 177.045757
Match: 1n11A_
Description: Ankyrin-R
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [681-748]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SYGHRFLDNN ESLILITLGS NDTRNKSPSI SLSSEALAKV IGLETDCALS LVISCNDSID  60
   61 KSSVILDL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.0
Match: 1sw6A_
Description: Swi6 ankyrin-repeat fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
glycerophosphodiester phosphodiesterase activity 4.27697417361287 bayes_pls_golite062009
phosphoric diester hydrolase activity 3.6633363681844 bayes_pls_golite062009
phospholipase activity 3.3535603060637 bayes_pls_golite062009
phosphoric ester hydrolase activity 2.89024275707278 bayes_pls_golite062009
phospholipase C activity 2.81479108775786 bayes_pls_golite062009
inositol or phosphatidylinositol phosphodiesterase activity 2.13368269358874 bayes_pls_golite062009
phosphoinositide phospholipase C activity 2.13368269358874 bayes_pls_golite062009
hydrolase activity 1.64631444998344 bayes_pls_golite062009
lipase activity 1.30779031242608 bayes_pls_golite062009
phosphatidylglycerol phospholipase C activity 1.28645679518658 bayes_pls_golite062009
catalytic activity 1.22328099675039 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.21202479488854 bayes_pls_golite062009
binding 0.701659508863933 bayes_pls_golite062009
protein binding 0.137516733383577 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [749-857]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLDDNVDAVD FKVPFKVDYS HTLYFDIVPT YGTRSLETHN RIDCQKNNNN YVMARGVSML  60
   61 NKSYSSVGVN RSILNGSVTV PIIANHTLEI LGTLKFEYII ITPFEHPQL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [858-1039]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLERTETYWK SLVSTRVIGH RGLGKNNPNK SLQIGENTVE SFIMAASLGA SYVEFDVQLT  60
   61 KDNVPVVYHD FLVAETGVDI PMHELTLEQF LDLNNADKEH IQRGAGHSPH HVNGADTALQ 120
  121 KYRGRSVDDS DVSTLRRAWD LHDNDPNGKS NNAHWSDNRM RLTKTFKKNN FKGNARGHSI 180
  181 AS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.69897
Match: 1o1zA_
Description: Hypothetical protein TM1621
Matching Structure (courtesy of the PDB):

Predicted Domain #9
Region A:
Residues: [1040-1223]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFVTLKELFK KIPANVGFNI ECKFPMLDEA EEEELGQIMM EMNHWVDTVL KVVFDNANGR  60
   61 DIIFSSFHPD ICIMLSLKQP VIPILFLTEG GSEQMADLRA SSLQNGIRFA KKWNLLGIVS 120
  121 AAAPILKAPR LVQVVKSNGL VCVTYGVDNN DPENASIQIE AGVDAVIVDS VLAIRRGLTK 180
  181 KNEK

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 14.130768
Match: PF03009
Description: Glycerophosphoryl diester phosphodiesterase family

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle