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View Structure Prediction Details

Protein: MET12
Organism: Saccharomyces cerevisiae
Length: 657 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MET12.

Description E-value Query
Range
Subject
Range
gi|114553992 - gi|114553992|ref|XP_001141277.1| PREDICTED: 5,10-methylenetetrahydrofolate reductase (NADPH) isoform...
821.0 [0..2] [655..67]
gi|4753778 - gi|4753778|emb|CAB41971.1| methylenetetrahydrofolate reductase [Homo sapiens]
819.0 [0..2] [655..67]
gi|108997188 - gi|108997188|ref|XP_001105108.1| PREDICTED: similar to 5,10-methylenetetrahydrofolate reductase isof...
817.0 [0..2] [655..67]

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Predicted Domain #1
Region A:
Residues: [1-324]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIRDLYHAR ASPFISLEFF PPKTELGTRN LMERMHRMTA LDPLFITVTW GAGGTTAEKT  60
   61 LTLASLAQQT LNIPVCMHLT CTNTEKAIID DALDRCYNAG IRNILALRGD PPIGEDWLDS 120
  121 QSNESPFKYA VDLVRYIKQS YGDKFCVGVA AYPEGHCEGE AEGHEQDPLK DLVYLKEKVE 180
  181 AGADFVITQL FYDVEKFLTF EMLFRERISQ DLPLFPGLMP INSYLLFHRA AKLSHASIPP 240
  241 AILSRFPPEI QSDDNAVKSI GVDILIELIQ EIYQRTSGRI KGFHFYTLNL EKAIAQIVSQ 300
  301 SPVLSHIVNE SSEEEGEDET SGEI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 416.502279
Match: 1b5tA
Description: Methylenetetrahydrofolate reductase
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [325-393]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSIENVPIED ADGDIVLDDS NEETVANRKR RRHSSLDSAK LIFNRAIVTE KGLRYNNENG  60
   61 SMPSKKALI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.516 a.101.1 Uteroglobin-like
View Download 0.464 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.464 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.443 a.4.5 "Winged helix" DNA-binding domain
View Download 0.430 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.430 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.417 a.276.1 Description not found.
View Download 0.393 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.319 a.4.5 "Winged helix" DNA-binding domain

Predicted Domain #3
Region A:
Residues: [394-657]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SISKGHGTLG RDATWDEFPN GRFGDSRSPA YGEIDGYGPS IKVSKSKALE LWGIPKTIGD  60
   61 LKDIFIKYLE GSTDAIPWSD LGLSAETALI QEELIQLNYR GYLTLASQPA TNATLSSDKI 120
  121 FGWGPAKGRL YQKAFVEMFI HRQQWETTLK PKLDHYGRRK FSYYAGDSSG SFETNLDPHS 180
  181 SSVVTWGVFP NSPVKQTTII EEESFKAWRD EAFSIWSEWA KLFPRNTPAN ILLRLVHKDY 240
  241 CLVSIVHHDF KETDELWEML LDQA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle