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View Structure Prediction Details

Protein: NCR1
Organism: Saccharomyces cerevisiae
Length: 1170 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NCR1.

Description E-value Query
Range
Subject
Range
gi|50978806, gi|... - gi|50978806|ref|NP_001003107.1| Niemann-Pick disease, type C1 [Canis lupus familiaris], gi|11878263|...
0.0 [1..1170] [8..1263]
NPC1 - Niemann-Pick disease, type C1
0.0 [1..1170] [8..1265]
NPC1_PIG - Niemann-Pick C1 protein OS=Sus scrofa GN=NPC1 PE=2 SV=1
0.0 [2..1170] [9..1264]
gi|20531742 - gi|20531742|gb|AAM27451.1| Niemann-Pick C1 [Felis catus]
0.0 [1..1170] [8..1263]
gi|6934272 - gi|6934272|gb|AAF31692.1|AF182744_1 Niemann-Pick type C1 protein [Cricetulus griseus]
0.0 [1..1170] [8..1264]
NCR1 - Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, i...
gi|190407939 - gi|190407939|gb|EDV11204.1| transmembrane protein [Saccharomyces cerevisiae RM11-1a]
NPC1_YEAST - Niemann-Pick type C-related protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NC...
0.0 [1..1170] [1..1170]
gi|27807461, gi|... - gi|27807461|ref|NP_777183.1| Niemann-Pick disease, type C1 [Bos taurus], gi|10945625|gb|AAG24620.1|A...
0.0 [2..1170] [9..1264]
gi|30851359, gi|... - gi|32452030|gb|AAH54539.1| Niemann Pick type C1 [Mus musculus], gi|30851359|gb|AAH52437.1| Niemann P...
0.0 [1..1170] [8..1264]

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Predicted Domain #1
Region A:
Residues: [1-284]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNVLWIIALV GQLMRLVQGT ATCAMYGNCG KKSVFGNELP CPVPRSFEPP VLSDETSKLL  60
   61 VEVCGEEWKE VRYACCTKDQ VVALRDNLQK AQPLISSCPA CLKNFNNLFC HFTCAADQGR 120
  121 FVNITKVEKS KEDKDIVAEL DVFMNSSWAS EFYDSCKNIK FSATNGYAMD LIGGGAKNYS 180
  181 QFLKFLGDAK PMLGGSPFQI NYKYDLANEE KEWQEFNDEV YACDDAQYKC ACSDCQESCP 240
  241 HLKPLKDGVC KVGPLPCFSL SVLIFYTICA LFAFMWYYLC KRKK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [285-391]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGAMIVDDDI VPESGSLDES ETNVFESFNN ETNFFNGKLA NLFTKVGQFS VENPYKILIT  60
   61 TVFSIFVFSF IIFQYATLET DPINLWVSKN SEKFKEKEYF DDNFGPF

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [490-547]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNLLFSDDDI LNAHAFVVTL LLTNHTQSAN RWEERLEEYL LDLKVPEGLR ISFNTEIS

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [778-886]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAVPQDSYLV DYFKDVYSFL NVGPPVYMVV KNLDLTKRQN QQKICGKFTT CERDSLANVL  60
   61 EQERHRSTIT EPLANWLDDY FMFLNPQNDQ CCRLKKGTDE VCPPSFPSR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 191.0103
Match: 1oy6A_
Description: Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains; Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains; Multidrug efflux transporter AcrB transmembrane domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [392-489]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YRTEQIFVVN ETGPVLSYET LHWWFDVENF ITEELQSSEN IGYQDLCFRP TEDSTCVIES  60
   61 FTQYFQGALP NKDSWKRELQ ECGKFPVNCL PTFQQPLK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [548-777]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEKELNNNND ISTVAISYLM MFLYATWALR RKDGKTRLLL GISGLLIVLA SIVCAAGFLT  60
   61 LFGLKSTLII AEVIPFLILA IGIDNIFLIT HEYDRNCEQK PEYSIDQKII SAIGRMSPSI 120
  121 LMSLLCQTGC FLIAAFVTMP AVHNFAIYST VSVIFNGVLQ LTAYVSILSL YEKRSNYKQI 180
  181 TGNEETKESF LKTFYFKMLT QKRLIIIIFS AWFFTSLVFL PEIQFGLDQT 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 191.0103
Match: 1oy6A_
Description: Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains; Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains; Multidrug efflux transporter AcrB transmembrane domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [887-977]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RCETCFQQGS WNYNMSGFPE GKDFMEYLSI WINAPSDPCP LGGRAPYSTA LVYNETSVSA  60
   61 SVFRTAHHPL RSQKDFIQAY SDGVRISSSF P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.312 d.93.1 SH2 domain
View Download 0.692 d.58.4 Dimeric alpha+beta barrel
View Download 0.441 d.110.1 Profilin (actin-binding protein)
View Download 0.626 d.110.4 SNARE-like
View Download 0.673 d.31.1 Cdc48 domain 2-like
View Download 0.308 a.39.2 Insect pheromon/odorant-binding proteins
View Download 0.300 d.88.1 SRF-like
View Download 0.293 a.74.1 Cyclin-like
View Download 0.279 a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.276 d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.270 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.267 d.238.1 Hypothetical protein TM0875
View Download 0.256 d.15.6 Superantigen toxins, C-terminal domain
View Download 0.241 a.49.1 C-terminal domain of B transposition protein
View Download 0.241 d.50.1 dsRNA-binding domain-like
View Download 0.236 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.231 d.93.1 SH2 domain
View Download 0.222 d.93.1 SH2 domain
View Download 0.208 a.64.1 Saposin
View Download 0.203 g.52.1 Inhibitor of apoptosis (IAP) repeat

Predicted Domain #5
Region A:
Residues: [978-1170]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELDMFAYSPF YIFFVQYQTL GPLTLKLIGS AIILIFFISS VFLQNIRSSF LLALVVTMII  60
   61 VDIGALMALL GISLNAVSLV NLIICVGLGV EFCVHIVRSF TVVPSETKKD ANSRVLYSLN 120
  121 TIGESVIKGI TLTKFIGVCV LAFAQSKIFD VFYFRMWFTL IIVAALHALL FLPALLSLFG 180
  181 GESYRDDSIE AED

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle