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View Structure Prediction Details

Protein: MRS6
Organism: Saccharomyces cerevisiae
Length: 603 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MRS6.

Description E-value Query
Range
Subject
Range
MRS6 - Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is required for the pr...
RAEP_YEAST - Rab proteins geranylgeranyltransferase component A OS=Saccharomyces cerevisiae (strain ATCC 204508 /...
0.0 [1..603] [1..603]
gi|61372597, gi|... - gi|61372597|gb|AAX43872.1| GDP dissociation inhibitor 2 [synthetic construct], gi|30583991|gb|AAP362...
0.0 [45..434] [3..374]
gi|123994115, gi... - gi|60655407|gb|AAX32267.1| GDP dissociation inhibitor 2 [synthetic construct], gi|60655405|gb|AAX322...
GDI2 - GDP dissociation inhibitor 2
0.0 [45..434] [3..374]
gi|12841706 - gi|12841706|dbj|BAB25321.1| unnamed protein product [Mus musculus]
0.0 [45..434] [3..374]
gi|109132814, gi... - gi|109132816|ref|XP_001093290.1| PREDICTED: GDP dissociation inhibitor 1 isoform 5 [Macaca mulatta],...
GDIA_MACFA - Rab GDP dissociation inhibitor alpha OS=Macaca fascicularis GN=GDI1 PE=2 SV=1
gi|160213463 - gi|160213463|gb|ABX10991.1| GDP dissociation inhibitor 1 (predicted) [Papio anubis]
0.0 [45..434] [3..374]
GDIA_PONPY - Rab GDP dissociation inhibitor alpha OS=Pongo pygmaeus GN=GDI1 PE=2 SV=1
0.0 [45..434] [3..374]

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Predicted Domain #1
Region A:
Residues: [1-494]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSPERRPSM AERRPSFFSF TQNPSPLVVP HLAGIEDPLP ATTPDKVDVL IAGTGMVESV  60
   61 LAAALAWQGS NVLHIDKNDY YGDTSATLTV DQIKRWVNEV NEGSVSCYKN AKLYVSTLIG 120
  121 SGKYSSRDFG IDLSPKILFA KSDLLSILIK SRVHQYLEFQ SLSNFHTYEN DCFEKLTNTK 180
  181 QEIFTDQNLP LMTKRNLMKF IKFVLNWEAQ TEIWQPYAER TMSDFLGEKF KLEKPQVFEL 240
  241 IFSIGLCYDL NVKVPEALQR IRRYLTSFDV YGPFPALCSK YGGPGELSQG FCRSAAVGGA 300
  301 TYKLNEKLVS FNPTTKVATF QDGSKVEVSE KVIISPTQAP KDSKHVPQQQ YQVHRLTCIV 360
  361 ENPCTEWFNE GESAAMVVFP PGSLKSGNKE VVQAFILGAG SEICPEGTIV WYLSTTEQGP 420
  421 RAEMDIDAAL EAMEMALLRE SSSGLENDEE IVQLTGNGHT IVNSVKLGQS FKEYVPRERL 480
  481 QFLFKLYYTQ YTST

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 418.228787
Match: 1gnd__
Description: Guanine nucleotide dissosiation inhibitor, GDI
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
small GTPase regulator activity 1.82777033221452 bayes_pls_golite062009
binding 1.71679209220564 bayes_pls_golite062009
GTPase regulator activity 1.69589677829425 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.67690582043816 bayes_pls_golite062009
transporter activity 1.29839290134235 bayes_pls_golite062009
transcription regulator activity 1.27958088282173 bayes_pls_golite062009
nucleic acid binding 1.26584665095879 bayes_pls_golite062009
transmembrane transporter activity 1.07862908893913 bayes_pls_golite062009
catalytic activity 1.03127962968326 bayes_pls_golite062009
DNA binding 1.02814395937345 bayes_pls_golite062009
enzyme regulator activity 1.00883251592654 bayes_pls_golite062009
amine oxidase activity 0.93095855430028 bayes_pls_golite062009
transcription factor activity 0.569299976584703 bayes_pls_golite062009
substrate-specific transporter activity 0.556967966402473 bayes_pls_golite062009
GDP-dissociation inhibitor activity 0.387378304822822 bayes_pls_golite062009
protein binding 0.347133050347128 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.31459693204333 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [495-603]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPFGVVNSSF FDVNQDLEKK YIPGASDNGV IYTTMPSAEI SYDEVVTAAK VLYEKIVGSD  60
   61 DDFFDLDFED EDEIQASGVA NAEQFENAID DDDDVNMEGS GEFVGEMEI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle