YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: PDE2
Organism: Saccharomyces cerevisiae
Length: 526 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PDE2.

Description E-value Query
Range
Subject
Range
gi|172106 - gi|172106|gb|AAA34846.1| cAMP phosphodiesterase
569.0 [0..1] [526..1]
gi|2706887 - gi|2706887|gb|AAB96875.1| PDE4C-791 [Homo sapiens]
494.0 [0..98] [526..297]
gi|73986145 - gi|73986145|ref|XP_852383.1| PREDICTED: similar to cAMP-specific 3,5-cyclic phosphodiesterase 4C (DP...
494.0 [0..98] [526..396]
gi|76621077 - gi|76621077|ref|XP_602953.2| PREDICTED: similar to cAMP-specific 3,5-cyclic phosphodiesterase 4C (DP...
484.0 [0..98] [526..321]
gi|109503974, gi... - gi|109503974|ref|XP_001070301.1| PREDICTED: similar to cAMP-specific 3,5-cyclic phosphodiesterase 4C...
483.0 [0..98] [522..213]
PDE4C_MOUSE - cAMP-specific 3',5'-cyclic phosphodiesterase 4C OS=Mus musculus GN=Pde4c PE=1 SV=1
483.0 [0..98] [525..220]

Back

Predicted Domain #1
Region A:
Residues: [1-133]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTLFLIGIH EIEKSQTIVQ NEHYFDRVIE LQDLDSLMVA LYKDRVSPFP NVHNFETGVS  60
   61 IVLYDPSKFQ LSVRQLDVLF KRFFPSFNIS AIDHTREENL QRLECVEREN SICRNRITRI 120
  121 NHWMYHHHDD TPD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.597 a.4.1 Homeodomain-like
View Download 0.556 d.192.1 YlxR-like
View Download 0.538 d.192.1 YlxR-like
View Download 0.512 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.501 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.495 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.495 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.473 a.74.1 Cyclin-like

Predicted Domain #2
Region A:
Residues: [134-370]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GINKNSYGTV NGNSVPTQAC EANIYTLLLH LNDSKAQHLR KASVPRLIRN IEFMSFLSDP  60
   61 IEKISQEGSH YWNILSTWDF CALSLSTQEL IWCGFTLIKK LSKDAKVLIA DNKLLLLLFT 120
  121 LESSYHQVNK FHNFRHAIDV MQATWRLCTY LLKDNPVQTL LLCMAAIGHD VGHPGTNNQL 180
  181 LCNCESEVAQ NFKNVSILEN FHRELFQQLL SEHWPQLLSI SKKKFDFISE AILATDM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 236.0103
Match: 1oynA
Description: Catalytic domain of cyclic nucleotide phosphodiesterase pde4d
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [371-526]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALHSQYEDRL MHENPMKQIT LISLIIKAAD ISNVTRTLSI SARWAYLITL EFNDCALLET  60
   61 FHKAHRPEQD CFGDSYKNVD SPKEDLESIQ NILVNVTDPD DIIKDHPHIP NGQIFFINTF 120
  121 AEVFFNALSQ KFSGLKFLSD NVKINKEYWM KHKKPQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 236.0103
Match: 1oynA
Description: Catalytic domain of cyclic nucleotide phosphodiesterase pde4d
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle