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View Structure Prediction Details

Protein: MYO2
Organism: Saccharomyces cerevisiae
Length: 1574 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MYO2.

Description E-value Query
Range
Subject
Range
gi|37535568, gi|... - gi|37535568|ref|NP_922086.1| putative myosin [Oryza sativa (japonica cultivar-group)], gb|AAP54373.1...
0.0 [4..1093] [147..1170]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [5..1542] [9..1515]
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1
0.0 [2..1303] [31..1358]
gi|26337045 - gi|26337045|dbj|BAC32206.1| unnamed protein product [Mus musculus]
0.0 [3..879] [30..884]
gi|22121649 - gi|22121649|gb|AAM88909.1| fast myosin heavy chain HCII [Gallus gallus]
0.0 [2..1327] [32..1375]
gi|4505301, gi|1... - gi|4505301|ref|NP_002463.1| myosin, heavy polypeptide 8, skeletal muscle, perinatal [Homo sapiens], ...
0.0 [2..1327] [33..1370]
Mhc-PJ - The gene Myosin heavy chain is referred to in FlyBase by the symbol Dmel\Mhc (CG17927, FBgn0086783)....
0.0 [2..1364] [31..1406]
gi|9944237 - gi|9944237|emb|CAC05419.1| myosin VIIA [Danio rerio]
0.0 [6..1205] [7..1157]

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Predicted Domain #1
Region A:
Residues: [1-63]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFEVGTRCW YPHKELGWIG AEVIKNEFND GKYHLELQLE DDEIVSVDTK DLNNDKDQSL  60
   61 PLL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2630.0
Match: 1jwyA_
Description: Myosin S1 fragment, N-terminal domain; Myosin S1, motor domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [64-342]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNPPILEATE DLTSLSYLNE PAVLHAIKQR YSQLNIYTYS GIVLIATNPF DRVDQLYTQD  60
   61 MIQAYAGKRR GELEPHLFAI AEEAYRLMKN DKQNQTIVVS GESGAGKTVS AKYIMRYFAS 120
  121 VEEENSATVQ HQVEMSETEQ KILATNPIME AFGNAKTTRN DNSSRFGKYL EILFDKDTSI 180
  181 IGARIRTYLL ERSRLVYQPP IERNYHIFYQ LMAGLPAQTK EELHLTDASD YFYMNQGGDT 240
  241 KINGIDDAKE YKITVDALTL VGITKETQHQ IFKILAALL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [417-452]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SALFDWLVEN INTVLCNPAV NDQISSFIGV LDIYGF

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [653-697]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELMNTINSTN VHYIRCIKPN ADKEAWQFDN LMVLSQLRAC GVLET

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2630.0
Match: 1jwyA_
Description: Myosin S1 fragment, N-terminal domain; Myosin S1, motor domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [343-416]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HIGNIEIKKT RNDASLSADE PNLKLACELL GIDAYNFAKW VTKKQIITRS EKIVSNLNYS  60
   61 QALVAKDSVA KFIY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [453-483]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EHFEKNSFEQ FCINYANEKL QQEFNQHVFK L

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [498-652]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IEFNDNQPCI DLIENKLGIL SLLDEESRLP AGSDESWTQK LYQTLDKSPT NKVFSKPRFG  60
   61 QTKFIVSHYA LDVAYDVEGF IEKNRDTVSD GHLEVLKAST NETLINILEG LEKAAKKLEE 120
  121 AKKLELEQAG SKKPGPIRTV NRKPTLGSMF KQSLI

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [698-701]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IRIS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2630.0
Match: 1jwyA_
Description: Myosin S1 fragment, N-terminal domain; Myosin S1, motor domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [484-497]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EQEEYVKEEI EWSF

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [702-783]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CAGFPSRWTF EEFVLRYYIL IPHEQWDLIF KKKETTEEDI ISVVKMILDA TVKDKSKYQI  60
   61 GNTKIFFKAG MLAYLEKLRS NK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2630.0
Match: 1jwyA_
Description: Myosin S1 fragment, N-terminal domain; Myosin S1, motor domain
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [784-844]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHNSIVMIQK KIRAKYYRKQ YLQISQAIKY LQNNIKGFII RQRVNDEMKV NCATLLQAAY  60
   61 R

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.522879
Match: 1wdcA_
Description: SCALLOP MYOSIN REGULATORY DOMAIN
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [845-1009]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GHSIRANVFS VLRTITNLQK KIRKELKQRQ LKQEHEYNAA VTIQSKVRTF EPRSRFLRTK  60
   61 KDTVVVQSLI RRRAAQRKLK QLKADAKSVN HLKEVSYKLE NKVIELTQNL ASKVKENKEM 120
  121 TERIKELQVQ VEESAKLQET LENMKKEHLI DIDNQKSKDM ELQKT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.0
Match: 1cii__
Description: Colicin Ia; Colicin Ia, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [1010-1327]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IENNLQSTEQ TLKDAQLELE DMVKQHDELK EESKKQLEEL EQTKKTLVEY QTLNGDLQNE  60
   61 VKSLKEEIAR LQTAMSLGTV TTSVLPQTPL KDVMGGGASN FNNMMLENSD LSPNDLNLKS 120
  121 RSTPSSGNNH IDSLSVDREN GVNATQINEE LYRLLEDTEI LNQEITEGLL KGFEVPDAGV 180
  181 AIQLSKRDVV YPARILIIVL SEMWRFGLTK QSESFLAQVL TTIQKVVTQL KGNDLIPSGV 240
  241 FWLANVRELY SFVVFALNSI LTEETFKNGM TDEEYKEYVS LVTELKDDFE ALSYNIYNIW 300
  301 LKKLQKQLQK KAINAVVI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.0
Match: 1cii__
Description: Colicin Ia; Colicin Ia, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [1328-1380]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SESLPGFSAG ETSGFLNKIF ANTEEYTMDD ILTFFNSIYW CMKSFHIENE VFH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.390 d.58.17 Metal-binding domain
View Download 0.535 a.140.1 LEM domain
View Download 0.445 a.32.1 Transcription factor IIA (TFIIA), alpha-helical domain
View Download 0.373 d.58.48 MTH1187-like
View Download 0.368 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.367 a.5.2 UBA-like
View Download 0.351 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.337 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.325 f.13.1 Family A G protein-coupled receptor-like
View Download 0.296 a.6.1 Putative DNA-binding domain
View Download 0.294 d.58.11 EF-G/eEF-2 domains III and V
View Download 0.274 a.4.1 Homeodomain-like
View Download 0.270 a.64.1 Saposin
View Download 0.264 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.234 a.140.3 Rho termination factor, N-terminal domain
View Download 0.234 d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.230 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.229 a.4.1 Homeodomain-like
View Download 0.221 a.144.1 PABC (PABP) domain
View Download 0.212 a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.212 a.10.1 Protozoan pheromone proteins
View Download 0.210 a.22.1 Histone-fold
View Download 0.209 d.58.1 4Fe-4S ferredoxins
View Download 0.208 g.34.1 HIV-1 VPU cytoplasmic domain

Predicted Domain #9
Region A:
Residues: [1381-1509]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AVVTTLLNYV DAICFNELIM KRNFLSWKRG LQLNYNVTRL EEWCKTHGLT DGTECLQHLI  60
   61 QTAKLLQVRK YTIEDIDILR GICYSLTPAQ LQKLISQYQV ADYESPIPQE ILRYVADIVK 120
  121 KEAALSSSG

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 46.657577
Match: PF01843
Description: DIL domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1510-1574]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDSKGHEHSS SIFITPETGP FTDPFSLIKT RKFDQVEAYI PAWLSLPSTK RIVDLVAQQV  60
   61 VQDGH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.681 0.945 microfilament motor activity a.39.1 EF-hand
View Download 0.455 0.945 microfilament motor activity a.4.1 Homeodomain-like
View Download 0.430 0.945 microfilament motor activity a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.745 0.945 microfilament motor activity a.50.1 Anaphylotoxins (complement system)
View Download 0.443 0.945 microfilament motor activity a.4.1 Homeodomain-like
View Download 0.430 0.945 microfilament motor activity b.84.2 Rudiment single hybrid motif
View Download 0.383 0.945 microfilament motor activity a.159.1 Protein serine/threonine phosphatase 2C, C-terminal domain
View Download 0.358 0.945 microfilament motor activity a.60.1 SAM/Pointed domain
View Download 0.333 0.945 microfilament motor activity a.3.1 Cytochrome c
View Download 0.317 0.945 microfilament motor activity a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.313 0.945 microfilament motor activity a.101.1 Uteroglobin-like
View Download 0.301 0.945 microfilament motor activity a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.300 0.945 microfilament motor activity a.3.1 Cytochrome c
View Download 0.300 0.945 microfilament motor activity a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.290 0.945 microfilament motor activity a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.280 0.945 microfilament motor activity a.112.1 Description not found.
View Download 0.277 0.945 microfilament motor activity a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.276 0.945 microfilament motor activity a.23.5 Hemolysin expression modulating protein HHA
View Download 0.276 0.945 microfilament motor activity a.4.5 "Winged helix" DNA-binding domain
View Download 0.275 0.945 microfilament motor activity a.4.1 Homeodomain-like
View Download 0.274 0.945 microfilament motor activity a.39.1 EF-hand
View Download 0.263 0.945 microfilament motor activity a.60.4 DNA repair protein Rad51, N-terminal domain
View Download 0.262 0.945 microfilament motor activity a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.259 0.945 microfilament motor activity a.140.2 SAP domain
View Download 0.252 0.945 microfilament motor activity a.60.11 Hypothetical protein YjbJ
View Download 0.251 0.945 microfilament motor activity a.4.5 "Winged helix" DNA-binding domain
View Download 0.237 0.945 microfilament motor activity a.144.1 PABC (PABP) domain
View Download 0.235 0.945 microfilament motor activity a.60.8 HRDC-like
View Download 0.234 0.945 microfilament motor activity a.4.5 "Winged helix" DNA-binding domain
View Download 0.228 0.945 microfilament motor activity d.192.1 YlxR-like
View Download 0.225 0.945 microfilament motor activity a.64.1 Saposin
View Download 0.224 0.945 microfilament motor activity a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.223 0.945 microfilament motor activity a.4.1 Homeodomain-like
View Download 0.220 0.945 microfilament motor activity a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.219 0.945 microfilament motor activity a.39.1 EF-hand
View Download 0.214 0.945 microfilament motor activity a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.208 0.945 microfilament motor activity d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.207 0.945 microfilament motor activity d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.206 0.945 microfilament motor activity a.118.9 ENTH/VHS domain
View Download 0.205 0.945 microfilament motor activity a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.204 0.945 microfilament motor activity a.140.4 Recombination endonuclease VII, C-terminal and dimerization domains
View Download 0.200 0.945 microfilament motor activity a.60.5 Barrier-to-autointegration factor, BAF


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle