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View Structure Prediction Details

Protein: KIN4
Organism: Saccharomyces cerevisiae
Length: 800 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KIN4.

Description E-value Query
Range
Subject
Range
gi|151945321 - gi|151945321|gb|EDN63564.1| serine/threonine protein kinase [Saccharomyces cerevisiae YJM789]
KIN4 - Serine/threonine protein kinase that inhibits the mitotic exit network (MEN) when the spindle positi...
KIN4_YEAST - Serine/threonine-protein kinase KIN4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KIN...
gi|207341004 - gi|207341004|gb|EDZ69182.1| YOR233Wp-like protein [Saccharomyces cerevisiae AWRI1631]
0.0 [1..800] [1..800]
gi|18448971 - gi|18448971|gb|AAL69982.1|AF465413_1 MAP/microtubule affinity-regulating kinase 3 long isoform [Homo...
0.0 [6..690] [20..671]
gi|12313871, gi|... - gi|7595800|gb|AAF64455.1|AF240782_1 ELKL motif kinase 2 long form [Mus musculus], gi|12313871|ref|NP...
0.0 [6..690] [20..662]
MARK3_RAT - MAP/microtubule affinity-regulating kinase 3 OS=Rattus norvegicus GN=Mark3 PE=1 SV=1
0.0 [6..690] [20..715]

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Predicted Domain #1
Region A:
Residues: [1-101]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASVPKRHTY GGNVVTDRDR HSLQRNNEIL HPIHKNQRKH ATFGPYIIGS TLGEGEFGKV  60
   61 KLGWTKASSS NEVPKQVAIK LIRRDTIKKD ADKEIKIYRE I

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [115-131]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEEVLQNSKY IGIVLEF

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [344-416]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGRHSTYSSS ASSYSKSRDR NSLIIESTLE QHRMSPQLAT SRPASPTFST GSKVVLNDTK  60
   61 NDMKESNING ERT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 442.9897
Match: 1fotA_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [102-114]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NALKHLTHPN IIY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [132-343]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSGGEFYKYI QRKRRLKESS ACRLFAQLIS GVNYMHYKGL VHRDLKLENL LLDKHENLVI  60
   61 TDFGFVNEFF EDNELMKTSC GSPCYAAPEL VVSTKAYEAR KADVWSCGVI LYAMLAGYLP 120
  121 WDDDHENPTG DDIARLYKYI TQTPLKFPEY ITPIPRDLLR RILVPNPRRR INLQTIKRHV 180
  181 WLKPHEAFLS IQPNYWDEHL QKERPKPPNK GD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 442.9897
Match: 1fotA_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [417-800]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SASCRYTRDS KGNGQTQIEQ VSARHSSRGN KHTSVAGLVT IPGSPTTART RNAPSSKLTE  60
   61 HVKDSSQTSF TQEEFHRIGN YHVPRSRPRP TSYYPGLSRN TADNSLADIP VNKLGSNGRL 120
  121 TDAKDPVPLN AIHDTNKATI SNNSIMLLSE GPAAKTSPVD YHYAIGDLNH GDKPITEVID 180
  181 KINKDLTHKA AENGFPRESI DPESTSTILV TKEPTNSTDE DHVESQLENV GHSSNKSDAS 240
  241 SDKDSKKIYE KKRFSFMSLY SSLNGSRSTV ESRTSKGNAP PVSSRNPSGQ SNRSNIKITQ 300
  301 QQPRNLSDRV PNPDKKINDN RIRDNAPSYA ESENPGRSVR ASVMVSTLRE ENRSELSNEG 360
  361 NNVEAQTSTA RKVLNFFKRR SMRV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [558-664]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNSIMLLSEG PAAKTSPVDY HYAIGDLNHG DKPITEVIDK INKDLTHKAA ENGFPRESID  60
   61 PESTSTILVT KEPTNSTDED HVESQLENVG HSSNKSDASS DKDSKKI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [665-800]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YEKKRFSFMS LYSSLNGSRS TVESRTSKGN APPVSSRNPS GQSNRSNIKI TQQQPRNLSD  60
   61 RVPNPDKKIN DNRIRDNAPS YAESENPGRS VRASVMVSTL REENRSELSN EGNNVEAQTS 120
  121 TARKVLNFFK RRSMRV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle