YRC Public Data Repository - Protein Structure Prediction

Protein:	LIP5
Organism:	Saccharomyces cerevisiae
Length:	414 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LIP5.

Description	E-value	Query Range	Subject Range
LIPA_YEAS6 - Lipoyl synthase, mitochondrial OS=Saccharomyces cerevisiae (strain AWRI1631) GN=LIP5 PE=3 SV=1 LIPA_YEAS8 - Lipoyl synthase, mitochondrial OS=Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) ... LIPA_YEAS2 - Lipoyl synthase, mitochondrial OS=Saccharomyces cerevisiae (strain JAY291) GN=LIP5 PE=3 SV=1 LIPA_YEAS7 - Lipoyl synthase, mitochondrial OS=Saccharomyces cerevisiae (strain YJM789) GN=LIP5 PE=3 SV=1 LIPA_YEAS1 - Lipoyl synthase, mitochondrial OS=Saccharomyces cerevisiae (strain RM11-1a) GN=LIP5 PE=3 SV=1 LIPA_YEAST - Lipoyl synthase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LIP5 PE=1... LIP5 - Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid ...	0.0	[1..414]	[1..414]
LIAS_MOUSE - Lipoyl synthase, mitochondrial OS=Mus musculus GN=Lias PE=1 SV=1	6.0E-96	[82..414]	[35..369]
SPBC8D2.15 - mitochondrial lipoic acid synthetase LIPA_SCHPO - Lipoyl synthase, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=lip5 PE=3 S...	1.0E-95	[81..412]	[27..362]
LISC_ARATH - Lipoyl synthase, chloroplastic OS=Arabidopsis thaliana GN=LIP1P PE=2 SV=2	3.0E-90	[95..414]	[70..391]
gi\|7296306, gi\|1... - gi\|7296306\|gb\|AAF51596.1\| CG5231-PA, isoform A [Drosophila melanogaster], gi\|28380901\|gb\|AAO41414.1\|... gi\|220954722 - gi\|220954722\|gb\|ACL89904.1\| Las-PC [synthetic construct]	2.0E-88	[69..414]	[21..370]
gi\|167422569, gi... - gi\|167422569\|ref\|ZP_02314322.1\| lipoic acid synthetase [Yersinia pestis biovar Orientalis str. MG05-... gi\|167057867, gi... - gi\|167423697\|ref\|ZP_02315450.1\| lipoic acid synthetase [Yersinia pestis biovar Mediaevalis str. K197... gi\|167470781 - gi\|167470781\|ref\|ZP_02335485.1\| lipoic acid synthetase [Yersinia pestis FV-1] LIPA_YERPY - Lipoyl synthase OS=Yersinia pseudotuberculosis serotype O:3 (strain YPIII) GN=lipA PE=3 SV=1 LIPA_YERPB - Lipoyl synthase OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+) GN=lipA PE=3 SV=1 gi\|165937740, gi... - gi\|89102289\|ref\|ZP_01174934.1\| COG0320: Lipoate synthase [Yersinia pestis biovar Orientalis str. IP2... gi\|229898745, gi... - gi\|229898745\|ref\|ZP_04513890.1\| lipoate synthase [Yersinia pestis biovar Orientalis str. India 195],... LIPA_YERPA - Lipoyl synthase OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=lipA PE=3 SV=1 gi\|229895935, gi... - gi\|229895935\|ref\|ZP_04511105.1\| lipoate synthase [Yersinia pestis Pestoides A], gi\|229700858\|gb\|EEO8... gi\|229694510, gi... - gi\|229838144\|ref\|ZP_04458303.1\| lipoate synthase [Yersinia pestis biovar Orientalis str. PEXU2], gi\|... gi\|165922979, gi... - gi\|165925372\|ref\|ZP_02221204.1\| lipoic acid synthetase [Yersinia pestis biovar Orientalis str. F1991... gi\|166008051, gi... - gi\|166008051\|ref\|ZP_02228949.1\| lipoic acid synthetase [Yersinia pestis biovar Antiqua str. E1979001... LIPA_YERPE - Lipoyl synthase OS=Yersinia pestis GN=lipA PE=3 SV=1 gi\|166212564, gi... - gi\|166212564\|ref\|ZP_02238599.1\| lipoic acid synthetase [Yersinia pestis biovar Antiqua str. B4200300... LIPA_YERPN - Lipoyl synthase OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=lipA PE=3 SV=1 LIPA_YERPG - Lipoyl synthase OS=Yersinia pestis bv. Antiqua (strain Angola) GN=lipA PE=3 SV=1 LIPA_YERPS - Lipoyl synthase OS=Yersinia pseudotuberculosis GN=lipA PE=3 SV=1 LIPA_YERP3 - Lipoyl synthase OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=lipA PE=3 SV=1 LIPA_YERPS - Lipoyl synthase OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=lipA PE=3 SV=1 gi\|149291914, gi... - gi\|149365501\|ref\|ZP_01887536.1\| lipoic acid synthetase [Yersinia pestis CA88-4125], gi\|149291914\|gb\|... gi\|22125074, gi\|... - gi\|22125074\|ref\|NP_668497.1\| lipoyl synthase [Yersinia pestis KIM], gi\|21957927\|gb\|AAM84748.1\|AE0137... gi\|15980585, gi\|... - gi\|218929679\|ref\|YP_002347554.1\| lipoyl synthase [Yersinia pestis CO92], gi\|16122811\|ref\|NP_406124.1... LIPA_YERPP - Lipoyl synthase OS=Yersinia pestis (strain Pestoides F) GN=lipA PE=3 SV=1	2.0E-86	[98..409]	[15..321]
LIPA_VIBCH - Lipoyl synthase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) GN=lipA PE=... LIPA_VIBCH - Lipoyl synthase OS=Vibrio cholerae GN=lipA PE=3 SV=1 gi\|229371129, gi... - gi\|229608474\|ref\|YP_002879122.1\| lipoate synthase [Vibrio cholerae MJ-1236], gi\|229371129\|gb\|ACQ6155... gi\|229344711, gi... - gi\|229517996\|ref\|ZP_04407440.1\| lipoate synthase [Vibrio cholerae RC9], gi\|229344711\|gb\|EEO09685.1\| ... gi\|153822114, gi... - gi\|229510875\|ref\|ZP_04400354.1\| lipoate synthase [Vibrio cholerae B33], gi\|229350840\|gb\|EEO15781.1\| ... gi\|116189619, gi... - gi\|75830694\|ref\|ZP_00759967.1\| COG0320: Lipoate synthase [Vibrio cholerae MO10], gi\|254848076\|ref\|ZP...	5.0E-86	[98..409]	[15..321]
LIPA_PASMU - Lipoyl synthase OS=Pasteurella multocida GN=lipA PE=3 SV=1 LIPA_PASMU - Lipoyl synthase OS=Pasteurella multocida (strain Pm70) GN=lipA PE=3 SV=1	9.0E-86	[98..409]	[15..320]

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Predicted Domain #1

Region A:
Residues: [1-177]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYRRSVGVLF VGRNTRWISS TIRCGTSATR PIRSNALNTD SDNASVRVPV GNSTEVENAT  60
   61 SQLTGTSGKR RKGNRKRITE FKDALNLGPS FADFVSGKAS KMILDPLEKA RQNTEEAKKL 120
  121 PRWLKVPIPK GTNYHKLKGD VKELGLSTVC EEARCPNIGE CWGGKDKSKA TATIMLL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [178-414]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDTCTRGCRF CSVKTNRTPS KPDPMEPENT AEAIKRWGLG YVVLTTVDRD DLVDGGANHL  60
   61 AETVRKIKQK APNTLVETLS GDFRGDLKMV DIMAQCGLDV YAHNLETVES LTPHVRDRRA 120
  121 TYRQSLSVLE RAKATVPSLI TKTSIMLGLG ETDEQITQTL KDLRNIQCDV VTFGQYMRPT 180
  181 KRHMKVVEYV KPEKFDYWKE RALEMGFLYC ASGPLVRSSY KAGEAFIENV LKKRNMK

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	8.19
Match:	1o0yA
Description:	Deoxyribose-phosphate aldolase DeoC
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits