YRC Public Data Repository - Protein Structure Prediction

Protein:	HEM15
Organism:	Saccharomyces cerevisiae
Length:	393 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HEM15.

Description	E-value	Query Range	Subject Range
HEMH_XENLA - Ferrochelatase, mitochondrial OS=Xenopus laevis GN=fech PE=1 SV=1	0.0	[3..373]	[20..392]
HEM15 - Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into... gi\|190407492 - gi\|190407492\|gb\|EDV10759.1\| ferrochelatase [Saccharomyces cerevisiae RM11-1a] gi\|151940658 - gi\|151940658\|gb\|EDN59071.1\| ferrochelatase [Saccharomyces cerevisiae YJM789] HEMH_YEAST - Ferrochelatase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HEM15 PE=1...	0.0	[1..393]	[1..393]
gi\|193271 - gi\|193271\|gb\|AAA37615.1\| ferrochelatase	0.0	[22..373]	[29..382]
HEMH_BOVIN - Ferrochelatase, mitochondrial OS=Bos taurus GN=FECH PE=1 SV=3	0.0	[19..373]	[42..398]
gi\|10567634, gi\|... - gi\|18858665\|ref\|NP_571706.1\| ferrochelatase [Danio rerio], gi\|10567634\|gb\|AAG18514.1\|AF250368_1 ferr...	0.0	[11..373]	[26..391]
HEMH_CHICK - Ferrochelatase, mitochondrial OS=Gallus gallus GN=FECH PE=1 SV=1	0.0	[19..373]	[28..384]
gi\|145579542, gi... - gi\|14719599\|pdb\|1HRK\|B Chain B, Crystal Structure Of Human Ferrochelatase, gi\|14719598\|pdb\|1HRK\|A Ch...	0.0	[35..373]	[1..341]
gi\|15147828 - gi\|15147828\|emb\|CAC50871.1\| ferrochelatase [Nicotiana tabacum]	0.0	[12..358]	[58..409]

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Predicted Domain #1

Region A:
Residues: [1-49]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSRTIRTQG SFLRRSQLTI TRSFSVTFNM QNAQKRSPTG IVLMNMGGP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [102-200]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPIRKWSEYQ ATEVCKILDK TCPETAPHKP YVAFRYAKPL TAETYKQMLK DGVKKAVAFS  60
   61 QYPHFSYSTT GSSINELWRQ IKALDSERSI SWSVIDRWP

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [341-393]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNQTFIEGMA DLVKSHLQSN QLYSNQLPLD FALGKSNDPV KDLSLVFGNH EST

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1041.218487
Match:	1hrkA_
Description:	Ferrochelatase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [50-101]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKVEETYDFL YQLFADNDLI PISAKYQKTI AKYIAKFRTP KIEKQYREIG GG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [201-340]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNEGLIKAFS ENITKKLQEF PQPVRDKVVL LFSAHSLPMD VVNTGDAYPA EVAATVYNIM  60
   61 QKLKFKNPYR LVWQSQVGPK PWLGAQTAEI AEFLGPKVDG LMFIPIAFTS DHIETLHEID 120
  121 LGVIGESEYK DKFKRCESLN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1041.218487
Match:	1hrkA_
Description:	Ferrochelatase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits