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View Structure Prediction Details

Protein: MED4
Organism: Saccharomyces cerevisiae
Length: 284 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MED4.

Description E-value Query
Range
Subject
Range
gi|190407490 - gi|190407490|gb|EDV10757.1| RNA polymerase II mediator complex subunit 4 [Saccharomyces cerevisiae R...
gi|151945791 - gi|151945791|gb|EDN64032.1| mediator complex subunit [Saccharomyces cerevisiae YJM789]
MED4_YEAST - Mediator of RNA polymerase II transcription subunit 4 OS=Saccharomyces cerevisiae (strain ATCC 20450...
MED4 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form ...
6.0E-90 [1..268] [1..268]
MED4_MOUSE - Mediator of RNA polymerase II transcription subunit 4 OS=Mus musculus GN=Med4 PE=2 SV=1
2.0E-63 [58..263] [54..256]
MED4_YARLI - Mediator of RNA polymerase II transcription subunit 4 OS=Yarrowia lipolytica (strain CLIB 122 / E 15...
MED4_YARLI - Mediator of RNA polymerase II transcription subunit 4 OS=Yarrowia lipolytica GN=MED4 PE=3 SV=1
2.0E-60 [16..279] [79..326]
gi|114649587 - gi|114649587|ref|XP_509775.2| PREDICTED: similar to VDRIP isoform 3 [Pan troglodytes]
MED4 - mediator complex subunit 4
5.0E-60 [58..263] [54..256]
pmc4 - RNA polymerase II holoenzyme component Pmc4
MED4_SCHPO - Mediator of RNA polymerase II transcription subunit 4 OS=Schizosaccharomyces pombe (strain 972 / ATC...
1.0E-58 [58..282] [23..234]
MED4_ARATH - Mediator of RNA polymerase II transcription subunit 4 OS=Arabidopsis thaliana GN=MED4 PE=1 SV=1
4.0E-39 [78..240] [153..334]
gi|220944668, gi... - gi|220954472|gb|ACL89779.1| MED4-PA [synthetic construct], gi|220944668|gb|ACL84877.1| MED4-PA [synt...
MED4-PA - The gene Mediator complex subunit 4 is referred to in FlyBase by the symbol Dmel\MED4 (CG8609, FBgn0...
8.0E-35 [68..204] [40..174]

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Predicted Domain #1
Region A:
Residues: [1-64]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVQDTKAVE FSMGHIRSSS VSLVAEATSN TNSEDKLSKV QLYEDLCRYE DTLSKLVESV  60
   61 DRFK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.648 0.978 transcription from RNA polymerase II promoter a.4.1 Homeodomain-like

Predicted Domain #2
Region A:
Residues: [65-284]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNLDIAKDLI RTDEALFENV KLLAEYDNIY RNLQKIDKDS EELDSKTRKI LEILNECHDE  60
   61 LKALPMLEQV EFEKNTILQQ RSKINSTELL DYATKLSKFT KIPPTFDKGA VGPNNFIWPA 120
  121 EDALRRGMLA MASLHSKELT RIPGEEVEET EVPTVPPSQS EEQKGQMAKK EGTPKTDSFI 180
  181 FDGTAKEVGD EADNTKDKEK EENNDDALDL DLDLFDPDDF 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle