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View Structure Prediction Details

Protein: TCB1
Organism: Saccharomyces cerevisiae
Length: 1186 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TCB1.

Description E-value Query
Range
Subject
Range
TCB1_YEAST - Tricalbin-1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TCB1 PE=1 SV=1
TCB1 - Lipid-binding protein containing three calcium and lipid binding domains; non-tagged protein localiz...
0.0 [1..1186] [1..1186]
gi|6687541 - gi|6687541|emb|CAB65007.1| transmembrane protein [Erysiphe pisi]
0.0 [23..1184] [87..1260]
YKH3_SCHPO - Uncharacterized protein PYUK71.03c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAPYUK...
SPAPYUK71.03c - C2 domain protein
0.0 [14..1177] [53..1211]
gi|190691873, gi... - gi|190691873|gb|ACE87711.1| family with sequence similarity 62 (C2 domain containing), member A prot...
ESYT1 - extended synaptotagmin-like protein 1
0.0 [115..930] [62..871]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [115..930] [20..839]
ESYT1_MOUSE - Extended synaptotagmin-1 OS=Mus musculus GN=Esyt1 PE=1 SV=2
0.0 [115..779] [52..760]
gi|3170547 - gi|3170547|gb|AAC34394.1| unknown [Takifugu rubripes]
0.0 [115..950] [42..960]

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Predicted Domain #1
Region A:
Residues: [1-80]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKEDTGVTA PKKPETAQVA NINGIDKLEP PKTKEETESS KSVSSEKAAH ASDESFKRSI  60
   61 HEASYVGWKQ IGGWEDKDEL 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.467 0.911 mitochondrion a.3.1 Cytochrome c
View Download 0.407 0.911 mitochondrion a.2.3 Chaperone J-domain
View Download 0.298 0.911 mitochondrion a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.467 0.911 mitochondrion a.3.1 Cytochrome c
View Download 0.407 0.911 mitochondrion a.2.3 Chaperone J-domain
View Download 0.325 0.911 mitochondrion a.3.1 Cytochrome c
View Download 0.325 0.911 mitochondrion a.3.1 Cytochrome c
View Download 0.323 0.911 mitochondrion a.3.1 Cytochrome c
View Download 0.298 0.911 mitochondrion a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.264 0.911 mitochondrion a.54.1 Domain of early E2A DNA-binding protein, ADDBP

Predicted Domain #2
Region A:
Residues: [81-370]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLDDELMDMT RETFLDNIIP DSLYGDWYHS VAIFFIGGVA SFALGHYKFS MGSAFFVIVI  60
   61 TSLLYRTSAK KYRGSIRELV QKEFTVQKVE NDYESLEWLN AFLDKYWPIL EPSVSQLIVQ 120
  121 QANEQMATNE AIPKFITQLW IDELTLGVKP PRVDLVKTFQ NTASDVVVMD WGISFTPHDL 180
  181 CDMSAKQVRN YVNELAVVKA KIFGITIPVS VSDIAFKAHA RVKFKLMTPF PHVETVNIQL 240
  241 LKVPDFDFVA TLFGRSIFNW EILAIPGLMT LIQKMAKKYM GPILLPPFSL 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [371-506]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLNIPQLLSG SNLSIGILEI TVKNAKGLKR TSSILNESID PYLSFEFNDI SIAKTRTVRD  60
   61 TLNPVWDETL YVLLNSFTDP LTISVYDKRA KLKDKVLGRI QYNLNTLHDK TTQRNLKAQF 120
  121 LRNSKPVGEL TFDLRF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.0
Match: 1gmiA_
Description: Domain from protein kinase C epsilon
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [507-640]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FPTLEEKKLP DGSVEELPDL NTGIAKVVVE EGSRFAEEEQ KVTAYVEVYL NAKLVLTTGK  60
   61 ATDTGTLKWN SDYEAVIADR RKTRYKFVVK DGKGEEIGST IQTLNDLIDR SQVNKNLIPL 120
  121 KNQKGDIKIT TYWR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 118.373389
Match: 1dqvA_
Description: Synaptogamin I
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [641-791]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVRLEIGSNS VAYTPPIGAI RVFIEKANDL RNLEKFGTID PYCKVLVNGL SKGRTDFKSQ  60
   61 TLNPVWNQVI YVAVTSPNQR ITLQCMDVET VNKDRSLGEF NVNVQDLFKK DENDKYEETI 120
  121 DEKAKVGRLV MPKKKPKGTI TYYTSFYPAL P

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 118.373389
Match: 1dqvA_
Description: Synaptogamin I
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [792-930]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VLTLEEIQDL DKVNKKKKAL ELRKSAIDEK KISKEDKAKF DQEWNEVKEL EDMYSNRQKL  60
   61 DLPELLQYNQ GVLAVTVLNG ELPDSGLYVQ AFFDDNGHPR FVSPRIPSRI VKNGWSGDVI 120
  121 IKELDKSITT FRVAKNKNY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [931-1130]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NRVEKCVCEV ELPTQELVKN CYYKPSILHL SGEGSAKLML QISWFPIDTK QLPANDLITN  60
   61 SGDLTIMSRS AENLIASDLN GYSDPYLKYY INNEEDCAYK TKVVKKTLNP KWNDEGTIQI 120
  121 NNRLNDVLRI KVMDWDSTSA DDTIGTAEIP LNKVKVEGTT ELDVPVEGLE NAGQDGGMLH 180
  181 LAFSFKPRYT ISVSKREKKV 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 117.325697
Match: 1dsyA_
Description: C2 domain from protein kinase c (alpha)
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [1131-1186]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDIASKGLGT GLKAGTTVIG GGVGAIGKIK KGVFGGLGSL TNHKKNHEMG EEETKF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.395 a.4.1 Homeodomain-like
View Download 0.391 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.362 a.4.10 N-terminal Zn binding domain of HIV integrase
View Download 0.515 a.64.2 Bacteriocin AS-48
View Download 0.319 d.50.3 PI-Pfui intein middle domain
View Download 0.291 a.164.1 C-terminal domain of DFF45/ICAD (DFF-C domain)
View Download 0.289 a.180.1 N-terminal, cytoplasmic domain of anti-sigmaE factor RseA
View Download 0.289 a.4.5 "Winged helix" DNA-binding domain
View Download 0.272 a.4.5 "Winged helix" DNA-binding domain
View Download 0.217 a.4.1 Homeodomain-like
View Download 0.205 a.15.1 TAF(II)230 TBP-binding fragment
View Download 0.201 a.135.1 Tetraspanin


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle