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View Structure Prediction Details

Protein: GYP1
Organism: Saccharomyces cerevisiae
Length: 637 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GYP1.

Description E-value Query
Range
Subject
Range
GYP1_YEAST - GTPase-activating protein GYP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GYP1 PE=1...
GYP1 - Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, ...
0.0 [1..637] [1..637]
gi|9790251, gi|9... - gi|988221|gb|AAA85223.1| Tbc1, gi|9790251|ref|NP_062610.1| TBC1 domain family, member 1 [Mus musculu...
1.0E-89 [21..636] [483..1085]
gi|14041976 - gi|14041976|dbj|BAB55057.1| unnamed protein product [Homo sapiens]
5.0E-88 [21..636] [31..633]
TB22B_MACFA - TBC1 domain family member 22B OS=Macaca fascicularis GN=TBC1D22B PE=2 SV=1
1.0E-80 [99..576] [22..504]
TBCD1_BOVIN, TBC... - TBC1 domain family member 1 (Fragment) OS=Bos taurus GN=TBC1D1 PE=2 SV=1, (O97790) TBC1 domain famil...
3.0E-79 [106..636] [3..515]

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Predicted Domain #1
Region A:
Residues: [1-238]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVRSAAKEM HERDHNSDSS SLVTSLMKSW RISSASSSKK PSLYKMNTTE STSLPSGYAS  60
   61 SADRDRRTSD GNFEAMAKQQ ASTRRTSNSY SPLRYVNPTL STASNESPRP ALLLRQHHQR 120
  121 HHHHQQPRHS SSGSVGNNCS NSTEPNKKGD RYFKDLDEDW SAVIDDYNMP IPILTNGGFG 180
  181 TPVAPTRTLS RKSTSSSINS ISNMGTSAVR NSSSSFTYPQ LPQLQKEKTN DSKKTQLE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [239-445]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IENERDVQEL NSIIQRISKF DNILKDKTII NQQDLRQISW NGIPKIHRPV VWKLLIGYLP  60
   61 VNTKRQEGFL QRKRKEYRDS LKHTFSDQHS RDIPTWHQIE IDIPRTNPHI PLYQFKSVQN 120
  121 SLQRILYLWA IRHPASGYVQ GINDLVTPFF ETFLTEYLPP SQIDDVEIKD PSTYMVDEQI 180
  181 TDLEADTFWC LTKLLEQITD NYIHGQP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [499-539]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RMWDTYLSET SQEVTSSYSM SSNDIKPPVT PTEPRVASFV T

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10084.0
Match: 1fkmA_
Description: Ypt/Rab-GAP domain of gyp1p
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [446-498]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GILRQVKNLS QLVKRIDADL YNHFQNEHVE FIQFAFRWMN CLLMREFQMG TVI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [540-637]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTKDFQSPTT ALSNMTPNNA VEDSGKMRQS SLNEFHVFVC AAFLIKWSDQ LMEMDFQETI  60
   61 TFLQNPPTKD WTETDIEMLL SEAFIWQSLY KDATSHWL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10084.0
Match: 1fkmA_
Description: Ypt/Rab-GAP domain of gyp1p
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase regulator activity 1.01713431388195 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.01642360334206 bayes_pls_golite062009
GTPase activator activity 0.505325037853263 bayes_pls_golite062009
enzyme regulator activity 0.434818760059511 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle