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View Structure Prediction Details

Protein: SKM1
Organism: Saccharomyces cerevisiae
Length: 655 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SKM1.

Description E-value Query
Range
Subject
Range
SKM1_YEAST - Serine/threonine-protein kinase SKM1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SKM...
SKM1 - Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; in...
0.0 [1..655] [1..655]
CLA4_ASHGO - Serine/threonine-protein kinase CLA4 OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 ...
CLA4_ASHGO - Serine/threonine-protein kinase CLA4 OS=Ashbya gossypii GN=CLA4 PE=3 SV=1
0.0 [5..654] [58..791]
gi|12060955 - gi|12060955|gb|AAG48308.1|AF315638_1 Ste20 a kinase [Filobasidiella neoformans]
0.0 [4..653] [71..636]
gi|12060951 - gi|12060951|gb|AAG48306.1|AF315636_1 STE20 [Cryptococcus neoformans var. grubii]
0.0 [4..653] [71..635]
gi|12744913 - gi|12744913|gb|AAK06844.1|AF332388_1 protein kinase STE20p [Pneumocystis carinii]
0.0 [2..641] [47..686]
gi|1256422 - gi|1256422|gb|AAC50590.1| PAK1
0.0 [30..652] [2..534]
PAK1_RAT - Serine/threonine-protein kinase PAK 1 OS=Rattus norvegicus GN=Pak1 PE=1 SV=3
0.0 [30..652] [2..533]

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Predicted Domain #1
Region A:
Residues: [1-117]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKGVKKEGWI SYKVDGLFSF LWQKRYLVLN DSYLAFYKSD KCNEEPVLSV PLTSITNVSR  60
   61 IQLKQNCFEI LRATDQKENI SPINSYFYES NSKRSIFIST RTERDLHGWL DAIFAKC

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 11.96
Match: 1fhwA
Description: Grp1
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [118-206]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLLSGVSSPT NFTHKVHVGF DPKVGNFVGV PDSWAKLLQT SEITYDDWNR NSKAVIKALQ  60
   61 FYEDYNGLDT MQFNDHLNTS LDLKPLKSP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 126.29073
Match: 1f3mA_
Description: pak1 autoregulatory domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [207-305]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TRYIINKRTN SIKRSVSRTL RKGKTDSILP VYQSELKPFP RPSDDDYKFT NIEDNKVREE  60
   61 GRVHVSKEST ADSQTKQLGK KEQKVIQSHL RRHDNNSTF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.389 0.862 protein serine/threonine kinase activity a.74.1 Cyclin-like
View Download 0.285 0.862 protein serine/threonine kinase activity a.7.1 Spectrin repeat
View Download 0.252 0.862 protein serine/threonine kinase activity a.47.2 t-snare proteins
View Download 0.389 0.862 protein serine/threonine kinase activity a.74.1 Cyclin-like
View Download 0.315 0.862 protein serine/threonine kinase activity a.29.4 RecG, N-terminal domain
View Download 0.315 0.862 protein serine/threonine kinase activity a.29.4 RecG, N-terminal domain
View Download 0.302 0.862 protein serine/threonine kinase activity a.74.1 Cyclin-like
View Download 0.285 0.862 protein serine/threonine kinase activity a.7.1 Spectrin repeat
View Download 0.252 0.862 protein serine/threonine kinase activity a.47.2 t-snare proteins
View Download 0.220 0.862 protein serine/threonine kinase activity a.46.1 Methionine synthase domain
View Download 0.216 0.862 protein serine/threonine kinase activity a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.201 0.862 protein serine/threonine kinase activity a.29.4 RecG, N-terminal domain

Predicted Domain #4
Region A:
Residues: [306-454]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPHRLAPSAP ATKNHDSKTK WHKEDLLELK NNDDSNEIIM KMKTVAIDVN PRPYFQLVEK  60
   61 AGQGASGAVY LSKRIKLPQE NDPRFLKSHC HRVVGERVAI KQIRLSEQPK KQLIMNELLV 120
  121 MNDSRQENIV NFLEAYIIDD EELWVIMEY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 959.0103
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [455-655]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGGCLTDIL DAVARSNTGE HSSPLNENQM AYIVKETCQG LKFLHNKKII HRDIKSDNIL  60
   61 LNSQGLVKIT DFGFCVELTE KRSKRATMVG TPYWMAPEIV NQKGYDEKVD VWSLGIMLIE 120
  121 MIEGEPPYLN EDPLKALYLI ANNGSPKLRH PESVSKQTKQ FLDACLQVNV ESRASVRKLL 180
  181 TFEFLSMACS PEQLKVSLKW H

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 959.0103
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle