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View Structure Prediction Details

Protein: AVO1
Organism: Saccharomyces cerevisiae
Length: 1176 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AVO1.

Description E-value Query
Range
Subject
Range
AVO1 - Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have...
AVO1_YEAST - Target of rapamycin complex 2 subunit AVO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ...
0.0 [1..1176] [1..1176]
sin1 - stress activated MAP kinase interacting protein Sin1
SIN1_SCHPO - Target of rapamycin complex 2 subunit sin1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN...
0.0 [456..920] [87..515]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [456..920] [72..500]
Sin1-PA - The gene SAPK-interacting protein 1 is referred to in FlyBase by the symbol Dmel\Sin1 (CG10105, FBgn...
6.0E-51 [641..805] [190..343]
gi|18026871 - gi|18026871|gb|AAL55663.1|AF237419_2 Sty1-interacting protein [Schizosaccharomyces pombe]
4.0E-47 [1063..1172] [48..154]
gi|13129138, gi|... - gi|57162289|emb|CAI39891.1| mitogen-activated protein kinase associated protein 1 [Homo sapiens], gi...
ENSPTRT00000039535 - null
gi|123984617, gi... - gi|157928446|gb|ABW03519.1| mitogen-activated protein kinase associated protein 1 [synthetic constru...
3.0E-46 [632..781] [112..271]

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Predicted Domain #1
Region A:
Residues: [1-615]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTVTVLNEL RAQFLRVCPE KDQMKRIIKP YIPVDEFNTE QCLDSSIREL YMNSDGVSLL  60
   61 PELESPPVSK DFMENYASLG KMRIMRENEG QKGKANQNLI GAEKTERDEE ETRNLQDKSA 120
  121 KNTLIVEENG TLRYNPLNSS ASNSLLNDDD HTSGKHHKTS SKEDSYLNSS MEMQKKSSKR 180
  181 SSLPFVRIFK SRRDHSNTSG NKNVMNTTNT RAKSSTLHPP GARHNKKGSK FDMNFDFDEN 240
  241 LEEEDDDDDD DEEGDDIHSQ FFQLDDDFDA KGSGASPAHK GINGMSNNKN NTYTNNRNSI 300
  301 SILDDRESSN GNIGSASRLK SHFPTSQKGK IFLTDNKNDG QKSDSLNANK GIHGDGSSAS 360
  361 GNGSVSRDGL TETESNNISD MESYINEKDL DDLNFDTVTS NINKTVSDLG GHESTNDGTA 420
  421 VMNRDSKDSR SNSNEFNAQN RDRITPGSSY GKSLLGSEYS EERYSNNDSS TMESGEMSLD 480
  481 SDMQTNTIPS HSIPMSMQKY GIYHGDDDST LNNVFDKAVL TMNSSRHPKE RRDTVISGKE 540
  541 PTSLTSSNRK FSVSSNLTST RSPLLRGHGR TSSTASSEHM KAPKVSDSVL HRARKSTLTL 600
  601 KQDHSQPSVP SSVHK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [616-791]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSKEGNILIE KTTDYLVSKP KASQLSNMFN KKKKRTNTNS VDVLEYFSFV CGDKVPNYES  60
   61 MGLEIYIQAS KKYKRNSFTT KVRKSSTIFE VIGFALFLYS TEKKPDNFEE DGLTVEDISN 120
  121 PNNFSLKIVD EDGEPFEDNF GKLDRKSTIQ SISDSEVVLC KVDDAEKSQN EIETPL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [792-1015]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PFETGGGLMD ASTLDANSSH DTTDGTINQL SFYKPIIGNE DDIDKTNGSK IIDVTVYLYP  60
   61 NVNPKFNYTT ISVLVTSHIN DILVKYCKMK NMDPNEYALK VLGKNYILDL NDTVLRLDGI 120
  121 NKVELISKKD ARELHLEKMK PDLKKPVLPT IQSNDLTPLT LEPLNSYLKA DAGGAVAAIP 180
  181 ENTKVTSKAK KISTKYKLGL AKQHSSSSVA SGSVSTAGGL ANGN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [1016-1176]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFFKNKNSSK SSLHGTLQFH NINRSQSTME HTPDTPNGVG DNFQDLFTGA YHKYKVWRRQ  60
   61 QMSFINKHER TLAIDGDYIY IVPPEGRIHW HDNVKTKSLH ISQVVLVKKS KRVPEHFKIF 120
  121 VRREGQDDIK RYYFEAVSGQ ECTEIVTRLQ NLLSAYRMNH K

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 2.0688320293797 bayes_pls_golite062009
protein binding 1.72968950672856 bayes_pls_golite062009
GTPase regulator activity 1.48723526514699 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.47132864518485 bayes_pls_golite062009
enzyme regulator activity 1.10772679848859 bayes_pls_golite062009
signal transducer activity 1.07208466109379 bayes_pls_golite062009
molecular transducer activity 1.07208466109379 bayes_pls_golite062009
small GTPase regulator activity 0.923576826164186 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.64016484101492 bayes_pls_golite062009
cytoskeletal protein binding 0.635109917427773 bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity 0.0559591386917759 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [931-1051]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPDLKKPVLP TIQSNDLTPL TLEPLNSYLK ADAGGAVAAI PENTKVTSKA KKISTKYKLG  60
   61 LAKQHSSSSV ASGSVSTAGG LANGNGFFKN KNSSKSSLHG TLQFHNINRS QSTMEHTPDT 120
  121 P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1052-1176]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGVGDNFQDL FTGAYHKYKV WRRQQMSFIN KHERTLAIDG DYIYIVPPEG RIHWHDNVKT  60
   61 KSLHISQVVL VKKSKRVPEH FKIFVRREGQ DDIKRYYFEA VSGQECTEIV TRLQNLLSAY 120
  121 RMNHK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.986
Match: 1p6sA
Description: Solution Structure of the Pleckstrin Homology Domain of Human Protein Kinase B beta (Pkb/Akt)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.52256824388179 bayes_pls_golite062009
protein binding 1.95763087285706 bayes_pls_golite062009
signal transducer activity 1.51882027675546 bayes_pls_golite062009
molecular transducer activity 1.51882027675546 bayes_pls_golite062009
GTPase regulator activity 1.50594272418871 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.48917924547615 bayes_pls_golite062009
actin binding 1.27269944962803 bayes_pls_golite062009
enzyme regulator activity 1.13267118951633 bayes_pls_golite062009
small GTPase regulator activity 1.10613306581585 bayes_pls_golite062009
cytoskeletal protein binding 0.972529924049714 bayes_pls_golite062009
protein domain specific binding 0.650240628628722 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.578612934164552 bayes_pls_golite062009
small GTPase binding 0.435164744647801 bayes_pls_golite062009
GTPase binding 0.423323808323435 bayes_pls_golite062009
receptor binding 0.391425518916624 bayes_pls_golite062009
receptor activity 0.361604826111032 bayes_pls_golite062009
transmembrane receptor activity 0.215248461701419 bayes_pls_golite062009
actin filament binding 2.21224577798385E-4 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle