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View Structure Prediction Details

Protein: HST1
Organism: Saccharomyces cerevisiae
Length: 503 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HST1.

Description E-value Query
Range
Subject
Range
HST1 - NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required fo...
HST1_YEAST - NAD-dependent protein deacetylase HST1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=H...
gi|151945566 - gi|151945566|gb|EDN63807.1| conserved protein [Saccharomyces cerevisiae YJM789]
0.0 [1..503] [1..503]
SIR2_KLULA - NAD-dependent histone deacetylase SIR2 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70...
SIR2_KLULA - NAD-dependent histone deacetylase SIR2 OS=Kluyveromyces lactis GN=SIR2 PE=3 SV=2
0.0 [54..494] [155..609]
SIR2_CANAL - NAD-dependent histone deacetylase SIR2 OS=Candida albicans GN=SIR2 PE=3 SV=1
0.0 [65..475] [91..489]
gi|31982681, gi|... - gi|31982681|ref|NP_071877.2| sirtuin 2 (silent mating type information regulation 2, homolog) 2 [Mus...
4.0E-91 [150..495] [24..362]
Sir2-PA - The gene Sir2 is referred to in FlyBase by the symbol Dmel\Sir2 (CG5216, FBgn0024291). It is a prote...
1.0E-90 [116..465] [120..480]
SIRT2 - sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
gi|114677027 - gi|114677027|ref|XP_001168375.1| PREDICTED: sirtuin 2 isoform 8 [Pan troglodytes]
1.0E-88 [150..495] [24..362]

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Predicted Domain #1
Region A:
Residues: [1-145]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNILLMQRIV SFILVVSQGR YFHVGELTMT MLKRPQEEES DNNATKKLKT RLTYPCILGK  60
   61 DKVTGKFIFP AITKDDVMNA RLFLKDNDLK TFLEYFLPVE VNSIYIYFMI KLLGFDVKDK 120
  121 ELFMALNSNI TSNKERSSAE LSSIH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [146-219]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKAEDEDELT DPLEKKHAVK LIKDLQKAIN KVLSTRLRLP NFNTIDHFTA TLRNAKKILV  60
   61 LTGAGVSTSL GIPD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [263-312]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPENMYSPLH SFIKMLQDKG KLLRNYTQNI DNLESYAGID PDKLVQCHGS 

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [391-503]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSRFHKTIRK DILECDLLIC IGTSLKVAPV SEIVNMVPSH VPQILINRDM VTHAEFDLNL  60
   61 LGFCDDVASL VAKKCHWDIP HKKWQDLKKI DYNCTEIDKG TYKIKKQPRK KQQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 475.39794
Match: 1j8fA_
Description: Sirt2 histone deacetylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein deacetylase activity 11.8771442637949 bayes_pls_golite062009
histone deacetylase activity 11.7308825525122 bayes_pls_golite062009
deacetylase activity 10.8368006972109 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 8.53375308475286 bayes_pls_golite062009
NAD-dependent protein deacetylase activity 8.13038616303736 bayes_pls_golite062009
NAD-dependent histone deacetylase activity 8.13038616303736 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 7.0185004322765 bayes_pls_golite062009
tubulin deacetylase activity 4.98963898611597 bayes_pls_golite062009
NAD+ ADP-ribosyltransferase activity 4.62921662347995 bayes_pls_golite062009
histone deacetylase activity (H3-K9 specific) 3.19556696137433 bayes_pls_golite062009
transcription regulator activity 2.9155913558118 bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H4-K16 specific) 2.54548484159934 bayes_pls_golite062009
DNA binding 2.43141001866996 bayes_pls_golite062009
nucleic acid binding 2.41433477472968 bayes_pls_golite062009
transcription repressor activity 2.24657784428979 bayes_pls_golite062009
binding 2.06552694538163 bayes_pls_golite062009
NAD-independent histone deacetylase activity 2.03444106183496 bayes_pls_golite062009
transcription corepressor activity 1.64212790017753 bayes_pls_golite062009
hydrolase activity 1.43067365161346 bayes_pls_golite062009
transcription factor activity 1.30143289828088 bayes_pls_golite062009
histone deacetylase activity (H3-K14 specific) 1.2707802007556 bayes_pls_golite062009
transcription factor binding 1.14766678956419 bayes_pls_golite062009
NAD(P)+-protein-arginine ADP-ribosyltransferase activity 0.963519974868694 bayes_pls_golite062009
catalytic activity 0.739210399081789 bayes_pls_golite062009
transcription cofactor activity 0.54005617175343 bayes_pls_golite062009
protein binding 0.475479132768057 bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H3-K14 specific) 0.412196364170961 bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H3-K9 specific) 0.412196364170961 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [220-262]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FRSSEGFYSK IRHLGLEDPQ DVFNLDIFLQ DPSVFYNIAH MVL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [313-390]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FATASCVTCH WQIPGEKIFE NIRNLELPLC PYCYQKRKQY FPMSNGNNTV QTNINFNSPI  60
   61 LKSYGVLKPD MTFFGEAL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 475.39794
Match: 1j8fA_
Description: Sirt2 histone deacetylase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle