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View Structure Prediction Details

Protein: TLG2
Organism: Saccharomyces cerevisiae
Length: 397 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TLG2.

Description E-value Query
Range
Subject
Range
TLG2_YEAST - T-SNARE affecting a late Golgi compartment protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508...
gi|190407325 - gi|190407325|gb|EDV10592.1| T-SNARE affecting a late Golgi compartment protein 2 [Saccharomyces cere...
TLG2 - Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-deri...
gi|207341320 - gi|207341320|gb|EDZ69408.1| YOL018Cp-like protein [Saccharomyces cerevisiae AWRI1631]
1.0E-72 [1..397] [1..397]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-52 [72..339] [1..258]
STX1A_MOUSE - Syntaxin-1A OS=Mus musculus GN=Stx1a PE=1 SV=3
8.0E-52 [53..340] [11..288]
gi|220902, gi|207127 - gi|220902|dbj|BAA02089.1| synaptotagmin associated 35kDa protein [Rattus norvegicus], gi|207127|gb|A...
gi|251470 - gi|251470|gb|AAB22525.1| syntaxin, P35A [rats, brain, Peptide Partial, 285 aa]
4.0E-51 [53..340] [8..285]
gi|7595847, gi|7... - gi|7595847|gb|AAF64478.1| syntaxin 1A [Macaca mulatta], gi|74136291|ref|NP_001028037.1| syntaxin 1B ...
3.0E-50 [53..339] [11..287]
STX1A_BOVIN - Syntaxin-1A OS=Bos taurus GN=STX1A PE=1 SV=1
3.0E-50 [53..340] [11..288]

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Predicted Domain #1
Region A:
Residues: [1-131]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRDRTNLFL SYRRTFPHNI TFSSGKAPLG DDQDIEMGTY PMMNMSHDIS ARLTDERKNK  60
   61 HENHSDALPP IFIDIAQDVD DYLLEVRRLS EQLAKVYRKN SLPGFEDKSH DEALIEDLSF 120
  121 KVIQMLQKCY A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.154902
Match: 1ez3A_
Description: Syntaxin 1A N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [132-203]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VMKRLKTIYN SQFVDGKQLS REELIILDNL QKIYAEKIQT ESNKFRVLQN NYLKFLNKDD  60
   61 LKPIRNKASA EN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.154902
Match: 1ez3A_
Description: Syntaxin 1A N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
SNAP receptor activity 3.50393203740159 bayes_pls_golite062009
protein transporter activity 2.96543140800925 bayes_pls_golite062009
phosphatidic acid binding 2.19104724611902 bayes_pls_golite062009
binding 2.13344290488739 bayes_pls_golite062009
transporter activity 1.74189664015129 bayes_pls_golite062009
protein binding 1.51700626946713 bayes_pls_golite062009
substrate-specific transporter activity 1.49085442233849 bayes_pls_golite062009
transmembrane transporter activity 1.13101548288086 bayes_pls_golite062009
excitatory extracellular ligand-gated ion channel activity 0.86350507004267 bayes_pls_golite062009
extracellular ligand-gated ion channel activity 0.86350507004267 bayes_pls_golite062009
SNARE binding 0.71459772253941 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.643064875848901 bayes_pls_golite062009
gated channel activity 0.621670335227137 bayes_pls_golite062009
ligand-gated ion channel activity 0.41937155561589 bayes_pls_golite062009
ligand-gated channel activity 0.41937155561589 bayes_pls_golite062009
ion transmembrane transporter activity 0.370484918396857 bayes_pls_golite062009
channel activity 0.0647076360772156 bayes_pls_golite062009
passive transmembrane transporter activity 0.0647076360772156 bayes_pls_golite062009
substrate-specific channel activity 0.0435980899803177 bayes_pls_golite062009
phospholipid binding 0.0172309833091902 bayes_pls_golite062009
cytoskeletal protein binding 0.00476738027966683 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [204-345]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLLLDDEEEE AAREKREGLD IEDYSKRTLQ RQQQLHDTSA EAYLRERDEE ITQLARGVLE  60
   61 VSTIFREMQD LVVDQGTIVD RIDYNLENTV VELKSADKEL NKATHYQKRT QKCKVILLLT 120
  121 LCVIALFFFV MLKPHGGGSG GR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.325697
Match: 1jthB_
Description: Syntaxin 1A
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [346-397]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNGSNKYNND DNKTVNNSHD DGSNTHINDE ESNLPSIVEV TESENDALDD LL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle