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View Structure Prediction Details

Protein: COS10
Organism: Saccharomyces cerevisiae
Length: 374 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for COS10.

Description E-value Query
Range
Subject
Range
COS1 - Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-enc...
COS1_YEAST - Protein COS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=COS1 PE=1 SV=1
511.0 [0..3] [373..10]

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Predicted Domain #1
Region A:
Residues: [1-59]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGEEIRLLSS KGLETHSSFC LPEDIFRNRL TWLCSEIRNS GFWIWSLSWL PLAVWWGMA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.300 N/A N/A a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.278 N/A N/A d.15.1 Ubiquitin-like
View Download 0.276 N/A N/A a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.262 N/A N/A d.214.1 Hypothetical protein MTH1880
View Download 0.255 N/A N/A a.5.1 DNA helicase RuvA subunit, C-terminal domain

Predicted Domain #2
Region A:
Residues: [60-173]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STWFYPLLTS VVLILALIAI LPVVQIQYSK YTLSNQLTQL SKEIIKSAPG AYSADWDAVA  60
   61 IHFNSYLYEN KAWKTAHFFF NGTDCQEAFR KTILEPAVLR RQNEDPRFSS IEIL

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 45.920819
Match: PF00674.9
Description: No description for PF00674.9 was found.

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.796 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.756 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.615 N/A N/A a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.569 N/A N/A a.29.2 Bromodomain

Predicted Domain #3
Region A:
Residues: [174-251]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPYTEDAVQV YFTKVNAQWR LIHGKKECKL TMLENVKLPK ETYRCKLAWS CQRIRISFSP  60
   61 LDFLPDMSDF FICANLSP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.612 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.593 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.573 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.517 a.77.1 DEATH domain
View Download 0.479 a.69.3 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain

Predicted Domain #4
Region A:
Residues: [252-374]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ACLVSYWLID IFFRMIDDFQ NIRPKSMKVD DKMQYLSDII NEQGASPEKW DTIARKTNTR  60
   61 LFEKRVWKNE EFFFDGTDCQ AFFERNFSSL LFSKKSASPR SLNVELWKYI QEAQLSCNYE 120
  121 PLP

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 51.537602
Match: PF00674.9
Description: No description for PF00674.9 was found.

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.439 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.412 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.375 N/A N/A a.174.1 Double Clp-N motif
View Download 0.332 N/A N/A a.1.1 Globin-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle