YRC Public Data Repository - Protein Structure Prediction

Protein:	YNR064C
Organism:	Saccharomyces cerevisiae
Length:	290 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YNR064C.

Description	E-value	Query Range	Subject Range
gi\|25533254 - pir\|\|AF2333 hypothetical protein all4221 [imported] - Nostoc sp. (strain PCC 7120) gi\|17231713, gi\|... - gi\|17231713\|ref\|NP_488261.1\| hypothetical protein all4221 [Nostoc sp. PCC 7120], gi\|17133356\|dbj\|BAB...	1.0E-55	[9..287]	[10..285]
YNR064C - Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification... YN93_YEAST - Uncharacterized hydrolase YNR064C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YNR064... gi\|207341527 - gi\|207341527\|gb\|EDZ69558.1\| YNR064Cp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190408938 - gi\|190408938\|gb\|EDV12203.1\| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]	1.0E-54	[1..290]	[1..290]
HYES_RAT - Bifunctional epoxide hydrolase 2 OS=Rattus norvegicus GN=Ephx2 PE=1 SV=1	2.0E-54	[6..288]	[235..542]
ceeh-1 - status:Confirmed UniProt:Q21147 protein_id:AAK95881.1	1.0E-53	[10..289]	[120..402]
HYES_MOUSE - Bifunctional epoxide hydrolase 2 OS=Mus musculus GN=Ephx2 PE=1 SV=2	1.0E-53	[6..288]	[235..542]
gi\|226245921, gi... - gi\|226350009\|ref\|YP_002777122.1\| putative 2-hydroxy-6-oxo-7-methylocta-2,4- dienoate hydrolase [Rhod... gi\|110823808, gi... - gi\|111024829\|ref\|YP_707249.1\| 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase [Rhodococcus jostii RHA1],... gi\|3273239 - gi\|3273239\|dbj\|BAA31163.1\| EtbD1 [Rhodococcus sp.] gi\|33867231, gi\|... - gi\|33867231\|ref\|NP_898789.1\| HOMODA-hydrolase (IpbD) [Rhodococcus erythropolis], gi\|33669065\|gb\|AAP7...	3.0E-53	[1..288]	[1..273]
gi\|50919593, gi\|... - gi\|50919593\|ref\|XP_470157.1\| putative hydrolase [Oryza sativa], gi\|28372678\|gb\|AAO39862.1\| putative ...	7.0E-53	[1..289]	[1..320]
gi\|1871461 - gi\|1871461\|dbj\|BAA12150.1\| 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase [Pseudomonas fluoresc... gi\|15076977 - gi\|15076977\|gb\|AAK83004.1\|AF285864_1 HOMODA hydrolase IpbD [Pseudomonas sp. JR1]	3.0E-52	[4..289]	[2..272]
gi\|15230018, gi\|... - gi\|6714450\|gb\|AAF26137.1\|AC011620_13 putative epoxide hydrolase [Arabidopsis thaliana], gi\|21436463\|...	6.0E-52	[9..289]	[6..323]

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Predicted Domain #1

Region A:
Residues: [1-290]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNIIARFHK IQVQDGVKVW YREAGAAGNP TILLLHGFPT SSNMFRNLIP LLAGQFHIIA  60
   61 PDLPGFGFTE TPENYKFSFD SLCESIGYLL DTLSIEKFAM YIFDYGSPVG FRLALKFPSR 120
  121 ITGIVTQNGN AYEEGLDDRF WGPLKEYWKS YQSDPVFVKS LIPYLEDPAN VICQYHDGVP 180
  181 AIESVDPAAY TLDIALIQRT GQTDIQLRLF FDYQNNIKLY PAFQKFLRDS KIPVLVAWGA 240
  241 NDTIFSVAGA EAYRKDVDNL KVVYYDTGHF ALETHVVAIA EEIISMFAEN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	182.68867
Match:	1bn6A_
Description:	Haloalkane dehalogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.39629727416851	bayes_pls_golite062009
hydrolase activity	0.804811554417903	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.137980423737024	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: