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View Structure Prediction Details

Protein: FPK1
Organism: Saccharomyces cerevisiae
Length: 893 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FPK1.

Description E-value Query
Range
Subject
Range
FPK1 - Ser/Thr protein kinase that regulates the putative phospholipid translocases Lem3p-Dnf1p/Dnf2p; phos...
FPK1_YEAST - Flippase kinase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FPK1 PE=1 SV=1
0.0 [1..893] [1..893]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [10..838] [337..1098]
gi|9844082 - gi|9844082|emb|CAC03748.1| cAMP-dependent protein kinase catalytic subunit [Botryotinia fuckeliana]
0.0 [54..864] [9..880]
gi|13537204, gi|... - gi|14149671|ref|NP_055927.1| microtubule associated serine/threonine kinase 2 [Homo sapiens], gi|135...
0.0 [71..873] [116..882]
MAST2_MOUSE - Microtubule-associated serine/threonine-protein kinase 2 OS=Mus musculus GN=Mast2 PE=1 SV=1
0.0 [71..873] [56..823]
gi|6006312 - gi|6006312|dbj|BAA84780.1| nonphototrophic hypocotyl 1a [Oryza sativa Japonica Group]
0.0 [142..791] [251..895]

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Predicted Domain #1
Region A:
Residues: [1-307]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGHHHEHEQ ERDHEQEHEH DSLQRPTTGS ERTRSISFSK LLTRSWKRNA SSSNNMSVSS  60
   61 VNLYSDPENS RESDHNNSGS EGQSSRFSKL KSMFQSGNSS KNASAHNSSQ SSLEGDSASS 120
  121 SSKLRYVKPM TSVANASPAS PPLSPTIPET DVLQTPKMVH IDQHEHEREH SNCGSPIMLS 180
  181 SSSFSPTVAR TGTGRRRSPS TPIMPSQNSN NSSSTSAIRP NNYRHHSGSQ GFSSNNPFRE 240
  241 RAGTVRSSNP YFAYQGLPTH AMSSHDLDEG FQPYANGSGI HFLSTPTSKT NSLTNTKNLS 300
  301 NLSLNEI

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.24
Match: 1k83A
Description: RBP1
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [308-426]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KENEEVQEFN NEDFFFHDIP KDLSLKDTLN GSPSRGSSKS PTITQTFPSI IVGFDNEYEE  60
   61 DNNNDKHDEK EEQQTTTDNK TRNLSPTKQN GKATHPRIKI PLRRAASEPN GLQLASATS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.354 d.93.1 SH2 domain
View Download 0.266 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.243 d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains

Predicted Domain #3
Region A:
Residues: [427-545]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTSSSARKTS GSSNINDKIP GQSVPPPNSF FPQEPSPKIS DFPEPRRSRR LRTKSFSNKF  60
   61 QDIMVGPQSF EKIRLLGQGD VGKVFLVREK KTNRVYALKV LSKDEMIKRN KIKRVLTEQ

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [559-575]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LYHSFQSEDY LYLCMEY

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [796-814]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSEDGYDFAK LSSNKKRQT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 712.0103
Match: 1fotA_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [546-558]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EILATSNHPF IVT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [576-795]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CMGGEFFRAL QTRKTKCICE DDARFYASEV TAALEYLHLL GFIYRDLKPE NILLHQSGHI  60
   61 MLSDFDLSIQ AKDSKVPVVK GSAQSTLVDT KICSDGFRTN SFVGTEEYIA PEVIRGNGHT 120
  121 AAVDWWTLGI LIYEMLFGFT PFKGDNTNET FTNILKNEVS FPNNNEISRT CKDLIKKLLT 180
  181 KNESKRLGCK MGAADVKKHP FFKKVQWSLL RNQEPPLIPV 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 712.0103
Match: 1fotA_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [815-893]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQDSHKHLDE QEKNMFEERV EYDDEVSEDD PFHDFNSMSL MEQDNNSMIY GNTNSYGKIA  60
   61 YTPNSNRSRS NSHRTFFKR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.396 b.38.1 Sm-like ribonucleoproteins
View Download 0.359 b.34.1 C-terminal domain of transcriptional repressors
View Download 0.432 a.60.2 RuvA domain 2-like
View Download 0.357 d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.534 b.38.2 YhbC-like, C-terminal domain
View Download 0.339 a.60.11 Hypothetical protein YjbJ
View Download 0.309 b.55.1 PH domain-like
View Download 0.307 d.150.1 4'-phosphopantetheinyl transferase
View Download 0.286 b.1.2 Fibronectin type III
View Download 0.283 b.55.1 PH domain-like
View Download 0.261 a.74.1 Cyclin-like
View Download 0.249 b.55.1 PH domain-like
View Download 0.249 a.3.1 Cytochrome c
View Download 0.244 c.51.3 B12-dependend dehydatases associated subunit
View Download 0.222 b.55.1 PH domain-like
View Download 0.220 b.1.1 Immunoglobulin
View Download 0.220 b.38.1 Sm-like ribonucleoproteins


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle