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View Structure Prediction Details

Protein: MVD1
Organism: Saccharomyces cerevisiae
Length: 396 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MVD1.

Description E-value Query
Range
Subject
Range
MVD1 - Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids...
MVD1_YEAST - Diphosphomevalonate decarboxylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MVD1 P...
4.0E-92 [1..396] [1..396]
gi|14250208, gi|... - gi|20149736|ref|NP_619597.1| mevalonate (diphospho) decarboxylase [Mus musculus], gi|14250208|gb|AAH...
9.0E-83 [5..395] [10..398]
MVD1_RAT - Diphosphomevalonate decarboxylase OS=Rattus norvegicus GN=Mvd PE=1 SV=1
1.0E-82 [5..395] [10..398]
MVD1_ARATH - Diphosphomevalonate decarboxylase MVD1 OS=Arabidopsis thaliana GN=MVD1 PE=1 SV=1
9.0E-82 [3..395] [7..412]
gi|60655429, gi|... - gi|60655429|gb|AAX32278.1| mevalonate (diphospho) decarboxylase [synthetic construct], gi|124126813|...
MVD - mevalonate (diphospho) decarboxylase
2.0E-80 [6..395] [10..397]
gi|16417950 - gi|16417950|gb|AAL18927.1|AF429386_1 mevalonate disphosphate decarboxylase [Hevea brasiliensis]
1.0E-79 [3..395] [6..415]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-77 [3..395] [7..413]

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Predicted Domain #1
Region A:
Residues: [1-396]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVYTASVTA PVNIATLKYW GKRDTKLNLP TNSSISVTLS QDDLRTLTSA ATAPEFERDT  60
   61 LWLNGEPHSI DNERTQNCLR DLRQLRKEME SKDASLPTLS QWKLHIVSEN NFPTAAGLAS 120
  121 SAAGFAALVS AIAKLYQLPQ STSEISRIAR KGSGSACRSL FGGYVAWEMG KAEDGHDSMA 180
  181 VQIADSSDWP QMKACVLVVS DIKKDVSSTQ GMQLTVATSE LFKERIEHVV PKRFEVMRKA 240
  241 IVEKDFATFA KETMMDSNSF HATCLDSFPP IFYMNDTSKR IISWCHTINQ FYGETIVAYT 300
  301 FDAGPNAVLY YLAENESKLF AFIYKLFGSV PGWDKKFTTE QLEAFNHQFE SSNFTARELD 360
  361 LELQKDVARV ILTQVGSGPQ ETNESLIDAK TGLPKE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10088.69897
Match: 1fi4A_
Description: Mevalonate 5-diphosphate decarboxylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
diphosphomevalonate decarboxylase activity 2.34245588421319 bayes_pls_golite062009
binding 1.48300512137561 bayes_pls_golite062009
catalytic activity 0.836142537655721 bayes_pls_golite062009
structural constituent of ribosome 0.66774567862554 bayes_pls_golite062009
carbohydrate kinase activity 0.49664490095304 bayes_pls_golite062009
structural molecule activity 0.40691892506083 bayes_pls_golite062009
nucleic acid binding 0.369771518688522 bayes_pls_golite062009
protein binding 0.214066724623027 bayes_pls_golite062009
transcription regulator activity 0.212099606954236 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle