YRC Public Data Repository - Protein Structure Prediction

Protein:	ARC35
Organism:	Saccharomyces cerevisiae
Length:	342 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARC35.

Description	E-value	Query Range	Subject Range
ARC35 - Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin pa... ARPC2_YEAST - Actin-related protein 2/3 complex subunit 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)... gi\|190408966 - gi\|190408966\|gb\|EDV12231.1\| ARP2/3 complex 34 kDa subunit [Saccharomyces cerevisiae RM11-1a] gi\|207341560 - gi\|207341560\|gb\|EDZ69582.1\| YNR035Cp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|151944564 - gi\|151944564\|gb\|EDN62842.1\| arp2/3 complex subunit [Saccharomyces cerevisiae YJM789]	0.0	[1..342]	[1..342]
gi\|220945922, gi... - gi\|220955618\|gb\|ACL90352.1\| Arc-p34-PA [synthetic construct], gi\|220945922\|gb\|ACL85504.1\| Arc-p34-PA... gi\|195580379, gi... - gi\|195580379\|ref\|XP_002080027.1\| GD24255 [Drosophila simulans], gi\|194192036\|gb\|EDX05612.1\| GD24255 ... Arc-p34-PA, FBpp... - The gene Arc-p34 is referred to in FlyBase by the symbol Dmel\Arc-p34 (CG10954, FBgn0032859). It is ... gi\|194124298, gi... - gi\|195351826\|ref\|XP_002042429.1\| GM23346 [Drosophila sechellia], gi\|194124298\|gb\|EDW46341.1\| GM23346...	0.0	[1..336]	[1..293]
gi\|56966194, gi\|... - gi\|56966194\|pdb\|1U2V\|C Chain C, Crystal Structure Of Arp23 COMPLEX WITH BOUND ADP AND Calcium, gi\|56...	0.0	[1..340]	[1..297]
ENSMMUT000000321... - null, null gi\|114583275, gi... - gi\|114583275\|ref\|XP_001155426.1\| PREDICTED: actin related protein 2/3 complex subunit 2 isoform 6 [P... ARPC2 - actin related protein 2/3 complex, subunit 2, 34kDa ENSOCUP000000047... - pep:novel chromosome:oryCun2:7:159575160:159605172:1 gene:ENSOCUG00000005516 transcript:ENSOCUT00000... ARPC2_PONPY - Actin-related protein 2/3 complex subunit 2 - Pongo pygmaeus (Orangutan) ENSCJAT00000021012 - null gi\|208965784, gi... - gi\|60655213\|gb\|AAX32170.1\| actin related protein 2/3 complex subunit 2 [synthetic construct], gi\|606... ARPC2_PONAB - Actin-related protein 2/3 complex subunit 2 OS=Pongo abelii GN=ARPC2 PE=2 SV=1	0.0	[1..340]	[1..297]
arx-4 - status:Confirmed UniProt:Q8WTM6 protein_id:AAL32261.1	0.0	[1..340]	[1..298]
arc2 - ARP2 /3 actin-organizing complex subunit Arc34 ARPC2_SCHPO - Actin-related protein 2/3 complex subunit 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) G...	0.0	[1..341]	[1..315]
ARC2A_ARATH - Actin-related protein 2/3 complex subunit 2A OS=Arabidopsis thaliana GN=ARPC2A PE=1 SV=1	3.0E-98	[1..317]	[1..295]
ARPC2_DICDI - Actin-related protein 2/3 complex subunit 2 OS=Dictyostelium discoideum GN=arcB PE=1 SV=1 gi\|60467975, gi\|... - gi\|66811280\|ref\|XP_639348.1\| actin related protein 2/3 complex, subunit 2 [Dictyostelium discoideum ...	5.0E-92	[1..340]	[1..290]

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Predicted Domain #1

Region A:
Residues: [1-128]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLHLQPQNLL IQKTLNEAIE ALRKGSPLTM DRIVSDFDYT TYHISNTAED KSILLLSVKT  60
   61 KAWVSVSECQ LDGSLTLLKF LADHYSSLGG VTIPSEVEPG YDYTLQITLA ELVQESILQL 120
  121 SVLKTIIL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	504.228787
Match:	1k8kD_
Description:	ARPC2 (34 kDa subunit)
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [129-342]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFPFELAISK FIELSQQQPA PVEAEITGGE VAANGDNTLF TIKYRDEENI FIKPSNDRVT  60
   61 IIFETIFQDE TDKIFGKVFL QEFVDARKRN RQIQSAPQVL YSHEPPLELK RLYQPPKVAE 120
  121 QSRRFITFVL FPRHFQTKEL QFHSICQLTL FRNYFHYHIK CSKAYMHSRM RFRVDSFIKV 180
  181 LNRAKVDEDD ENDELSAEGR QQARRTFTGR KIVY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	504.228787
Match:	1k8kD_
Description:	ARPC2 (34 kDa subunit)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits