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View Structure Prediction Details

Protein: COS1
Organism: Saccharomyces cerevisiae
Length: 381 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for COS1.

Description E-value Query
Range
Subject
Range
COS2, COS3 - Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-enc...
COS2_YEAST, COS3... - Protein COS3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=COS3 PE=1 SV=1, Protein COS...
597.0 [0..1] [377..1]

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Predicted Domain #1
Region A:
Residues: [1-61]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKENELKNEK SVDVLSFKQL ESQKIVLPQD LFRSSFTWFC YEIYKSLAFR IWMLLWLPLS  60
   61 V

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [62-171]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WWKLSNNCIY PLIVSLLVLF LGPIFVLVIC GLSRKRSLSK QLIQFCKEVT ENTPSSDPHD  60
   61 WEVVAANLNS YLYENKAWNT KYFFFNAMVC QEAFRTTLLE PFSLKKDEAA 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 52.443697
Match: PF00674
Description: DUP family

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.815 N/A N/A a.186.1 Description not found.
View Download 0.808 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.808 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.774 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.774 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.762 N/A N/A a.249.1 Description not found.
View Download 0.724 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.724 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.692 N/A N/A a.64.1 Saposin
View Download 0.675 N/A N/A a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3

Predicted Domain #3
Region A:
Residues: [172-241]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVKSFKDSVP YIEEALGVYF REVEKQWKLF NSEKSWSPVG LEDAKLPKEA YRFKLTWFLK  60
   61 RISNIFMLIP 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.653 f.28.1 Nonheme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.621 f.28.1 Nonheme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.534 a.48.4 Description not found.
View Download 0.513 d.74.5 Hypothetical protein Yml108w
View Download 0.454 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.454 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.443 a.60.8 HRDC-like
View Download 0.427 a.112.1 Description not found.
View Download 0.409 a.60.1 SAM/Pointed domain
View Download 0.405 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit

Predicted Domain #4
Region A:
Residues: [242-381]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FLNFLCCIYV SRGMCLLLRT FYLGWILFML VQGFQNMRMI VLSVKMEHKM QFLSTIINEQ  60
   61 ESGANGWDEI AKKMNRYLFE KKVWKNEEFF FDGIDCEWFF SHFFYRVLSA KKSMRALSLN 120
  121 VELWPYIKEA QLSCSEESLA 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 61.008774
Match: PF00674
Description: DUP family

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.545 N/A N/A a.24.3 Cytochromes
View Download 0.467 N/A N/A a.29.13 Description not found.
View Download 0.421 N/A N/A a.24.24 Description not found.
View Download 0.392 N/A N/A a.24.4 Hemerythrin
View Download 0.387 N/A N/A a.24.18 Description not found.
View Download 0.292 N/A N/A a.118.8 TPR-like
View Download 0.288 N/A N/A c.62.1 vWA-like
View Download 0.284 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.256 N/A N/A d.162.1 LDH C-terminal domain-like


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