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View Structure Prediction Details

Protein: RPD3
Organism: Saccharomyces cerevisiae
Length: 433 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RPD3.

Description E-value Query
Range
Subject
Range
RPD3 - Histone deacetylase; regulates transcription and silencing; plays a role in regulating Ty1 transposi...
ORFP:18105 - YNL330C, Contig c776 12841-14142 reverse complement
gi|190409292 - gi|190409292|gb|EDV12557.1| histone deacetylase [Saccharomyces cerevisiae RM11-1a]
RPD3_YEAST - Histone deacetylase RPD3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RPD3 PE=1 SV=1
0.0 [1..433] [1..433]
HDAC1_CHICK - Histone deacetylase 1 OS=Gallus gallus GN=HDAC1 PE=2 SV=1
0.0 [18..432] [8..420]
HDAC1_MOUSE - Histone deacetylase 1 OS=Mus musculus GN=Hdac1 PE=1 SV=1
0.0 [18..428] [8..416]
HDA1B_XENLA - Probable histone deacetylase 1-B OS=Xenopus laevis GN=hdac1-b PE=1 SV=1
0.0 [18..432] [8..420]
gi|14333978 - gi|14333978|gb|AAK58884.1| reduced potassium dependency 3 Rpd3p [Kluyveromyces lactis]
0.0 [1..432] [1..432]
HDAC1_PONPY - Histone deacetylase 1 - Pongo pygmaeus (Orangutan)
HDAC1 - histone deacetylase 1
gi|123995803, gi... - gi|61363144|gb|AAX42342.1| histone deacetylase 1 [synthetic construct], gi|60814459|gb|AAX36302.1| h...
HDAC1_PONAB - Histone deacetylase 1 OS=Pongo abelii GN=HDAC1 PE=2 SV=1
0.0 [18..428] [8..416]

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Predicted Domain #1
Region A:
Residues: [1-177]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVYEATPFDP ITVKPSDKRR VAYFYDADVG NYAYGAGHPM KPHRIRMAHS LIMNYGLYKK  60
   61 MEIYRAKPAT KQEMCQFHTD EYIDFLSRVT PDNLEMFKRE SVKFNVGDDC PVFDGLYEYC 120
  121 SISGGGSMEG AARLNRGKCD VAVNYAGGLH HAKKSEASGF CYLNDIVLGI IELLRYH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 507.40824
Match: 1c3rA_
Description: HDAC homologue
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [178-347]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRVLYIDIDV HHGDGVEEAF YTTDRVMTCS FHKYGEFFPG TGELRDIGVG AGKNYAVNVP  60
   61 LRDGIDDATY RSVFEPVIKK IMEWYQPSAV VLQCGGDSLS GDRLGCFNLS MEGHANCVNY 120
  121 VKSFGIPMMV VGGGGYTMRN VARTWCFETG LLNNVVLDKD LPYNEYYEYY 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 507.40824
Match: 1c3rA_
Description: HDAC homologue
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [348-433]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPDYKLSVRP SNMFNVNTPE YLDKVMTNIF ANLENTKYAP SVQLNHTPRD AEDLGDVEED  60
   61 SAEAKDTKGG SQYARDLHVE HDNEFY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle