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View Structure Prediction Details

Protein: SIN4
Organism: Saccharomyces cerevisiae
Length: 974 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SIN4.

Description E-value Query
Range
Subject
Range
SIN4 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form ...
MED16_YEAST - Mediator of RNA polymerase II transcription subunit 16 OS=Saccharomyces cerevisiae (strain ATCC 2045...
0.0 [1..974] [1..974]

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Predicted Domain #1
Region A:
Residues: [1-457]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMLGEHLMSW SKTGIIAYSD SQSSNANICL TFLESINGIN WRFHTPQKYV LHPQLHEVQY  60
   61 QESSSTLSTH STTTSVNGST TAGVGSTPNF GGNSNKSPPQ FFYNISSIHW NNWFSLPGDM 120
  121 LAVCDELGNM TMLITGQRPD RATTYEKLTM VFQDNVYKIY NHVMPLKPVD KLKPMNIERK 180
  181 QTRKEYNTSI LEFRWLTSSK SVIVSQFCAF DSSSNTYRSR AQQVPPYGVY HPPFIKYACL 240
  241 AIRKNGQIDF WYQFSNSKDH KKITLQLLDT SNQRFKDLQW LEFARITPMN DDQCMLITTY 300
  301 SKLSKNISFY KLHVNWNLNA TKPNVLNDPS LKIQFILSTT LDPTDDEGHV LKLENLHVVS 360
  361 KSSIEKDPSP EILVLYNVCD TSKSLVKRYR LAPTQLSAEY LVILKPDLNI DRNNSTNQIF 420
  421 QSRRYNLRRH SDIVLDKKVT LITSEMFDAF VSFYFED

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [458-641]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTIESYNQND WKLETERLIS QSQLGKFKNI IASPLSAGFN YGKLPLPPSV EWMKVSPSMC  60
   61 GVIVKQYNKK WPQFYAAVQK NYADPEKDSI NATALAFGYV KSLHKQISAE DLTIAAKTHI 120
  121 LRISFLDRKR AKEFITTLLK SLYSFFNISP DAPKEIMDKI ITSRPLQKIM LLQLELGSCF 180
  181 SQEN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [689-773]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IFSKQDLIHS LIPVAKWFVK FITYLTQEIL ILINDPTNKE YTLVHGIFGA KMSRTLILSI  60
   61 LNEIKKVTQI VAKFPETSYP ILNES

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.83
Match: 1qoyA
Description: Hemolysin E (HlyE, ClyA, SheA)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [642-688]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IEEMARVILY LKNVLFAFNG VARNFHFAIE QISNNSNQQQ NPKLFQT

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.83
Match: 1qoyA
Description: Hemolysin E (HlyE, ClyA, SheA)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [774-974]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STFLKLVLSE SPVDFEKFET FLVDVNNKFI ALCEQQPSQE REFSLLVKAE IPPEYAKVGD  60
   61 FLLQYANNAV ISHANAAAVY FADTSGLKIS NSEFFNPEIF HLLQPLEEGL IIDTDKLPIK 120
  121 NRTSKSFSKL LYDDVTCDKL SVSEISDGKL KRCSRCGSVT RAGNIISSDK TIVPTSIQTK 180
  181 RWPTMYTRLC ICSGMLFEMD G

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [691-807]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKQDLIHSLI PVAKWFVKFI TYLTQEILIL INDPTNKEYT LVHGIFGAKM SRTLILSILN  60
   61 EIKKVTQIVA KFPETSYPIL NESSTFLKLV LSESPVDFEK FETFLVDVNN KFIALCE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [808-974]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQPSQEREFS LLVKAEIPPE YAKVGDFLLQ YANNAVISHA NAAAVYFADT SGLKISNSEF  60
   61 FNPEIFHLLQ PLEEGLIIDT DKLPIKNRTS KSFSKLLYDD VTCDKLSVSE ISDGKLKRCS 120
  121 RCGSVTRAGN IISSDKTIVP TSIQTKRWPT MYTRLCICSG MLFEMDG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle