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View Structure Prediction Details

Protein: URE2
Organism: Saccharomyces cerevisiae
Length: 354 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for URE2.

Description E-value Query
Range
Subject
Range
URE2_SACPA - Protein URE2 OS=Saccharomyces paradoxus GN=URE2 PE=3 SV=1
URE2_SACDO - Protein URE2 OS=Saccharomyces douglasii GN=URE2 PE=3 SV=1
2.0E-91 [1..354] [1..359]
gi|151944317 - gi|151944317|gb|EDN62595.1| prion [Saccharomyces cerevisiae YJM789]
URE2_YEAST - Transcriptional regulator URE2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=URE2 PE=1...
gi|190409200 - gi|190409200|gb|EDV12465.1| protein URE2 [Saccharomyces cerevisiae RM11-1a]
gi|207341870 - gi|207341870|gb|EDZ69810.1| YNL229Cp-like protein [Saccharomyces cerevisiae AWRI1631]
URE2 - Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcripti...
3.0E-89 [1..354] [1..354]
URE2_KLULA - Protein URE2 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1...
URE2_KLULA - Protein URE2 OS=Kluyveromyces lactis GN=URE2 PE=3 SV=1
5.0E-78 [6..354] [11..389]
URE2_CANAL - Protein URE2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=URE2 PE=3 SV=1
URE2_CANAL - Protein URE2 OS=Candida albicans GN=URE2 PE=3 SV=1
1.0E-58 [16..354] [8..344]
gi|25287116, gi|... - gi|4127352|emb|CAA09190.1| glutathione transferase [Alopecurus myosuroides], pir||T52085 glutathione...
3.0E-55 [111..349] [1..209]
GSTF_HYOMU - Glutathione S-transferase OS=Hyoscyamus muticus PE=1 SV=1
2.0E-54 [113..351] [2..208]

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Predicted Domain #1
Region A:
Residues: [1-91]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMNNNGNQVS NLSNALRQVN IGNRNSNTTT DQSNINFEFS TGVNNNNNNN SSSNNNNVQN  60
   61 NNSGRNGSQN NDNENNIKNT LEQHRQQQQA F

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [92-199]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDMSHVEYSR ITKFFQEQPL EGYTLFSHRS APNGFKVAIV LSELGFHYNT IFLDFNLGEH  60
   61 RAPEFVSVNP NARVPALIDH GMDNLSIWES GAILLHLVNK YYKETGNP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [347-354]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VIKALRGE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1625.39794
Match: 1g6wA_
Description: Yeast prion protein ure2p, nitrogen regulation fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
antioxidant activity 3.66884588063322 bayes_pls_golite062009
peroxidase activity 3.43831566988273 bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor 3.43831566988273 bayes_pls_golite062009
glutathione binding 3.12157603958172 bayes_pls_golite062009
selenium binding 2.6356580403901 bayes_pls_golite062009
glutathione peroxidase activity 2.56524997297011 bayes_pls_golite062009
peroxiredoxin activity 2.12777217096121 bayes_pls_golite062009
thioredoxin peroxidase activity 1.96134566495756 bayes_pls_golite062009
glutathione transferase activity 1.85683051472829 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors 1.8187537496904 bayes_pls_golite062009
protein disulfide oxidoreductase activity 1.47769936616412 bayes_pls_golite062009
disulfide oxidoreductase activity 1.32811008894503 bayes_pls_golite062009
transcription regulator activity 1.27179487791083 bayes_pls_golite062009
binding 1.25802922431343 bayes_pls_golite062009
phospholipid-hydroperoxide glutathione peroxidase activity 0.874146425427531 bayes_pls_golite062009
catalytic activity 0.672192331361968 bayes_pls_golite062009
transferase activity 0.245320538630117 bayes_pls_golite062009
protein binding 0.134341907247724 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [200-346]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLWSDDLADQ SQINAWLFFQ TSGHAPMIGQ ALHFRYFHSQ KIASAVERYT DEVRRVYGVV  60
   61 EMALAERREA LVMELDTENA AAYSAGTTPM SQSRFFDYPV WLVGDKLTIA DLAFVPWNNV 120
  121 VDRIGINIKI EFPEVYKWTK HMMRRPA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1625.39794
Match: 1g6wA_
Description: Yeast prion protein ure2p, nitrogen regulation fragment
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle