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View Structure Prediction Details

Protein: SRV2
Organism: Saccharomyces cerevisiae
Length: 526 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SRV2.

Description E-value Query
Range
Subject
Range
CAP2 - CAP, adenylate cyclase-associated protein, 2 (yeast)
gi|61361754, gi|... - gi|61361754|gb|AAX42098.1| CAP adenylate cyclase-associated protein 2 [synthetic construct], gi|1239...
0.0 [11..524] [2..475]
CAP2_MOUSE - Adenylyl cyclase-associated protein 2 OS=Mus musculus GN=Cap2 PE=1 SV=1
0.0 [12..524] [3..474]
CAP2_RAT - Adenylyl cyclase-associated protein 2 OS=Rattus norvegicus GN=Cap2 PE=1 SV=1
0.0 [11..524] [2..475]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [11..526] [2..474]
SRV2 - CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cycl...
CAP_YEAST - Adenylyl cyclase-associated protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SRV2...
0.0 [1..526] [1..526]
gi|31747011, gi|... - gi|31747011|gb|AAP57716.1| cyclase-associated protein 1a [Xenopus laevis], gi|27370990|gb|AAH41224.1...
0.0 [11..526] [2..475]
gi|13874486 - gi|13874486|dbj|BAB46867.1| hypothetical protein [Macaca fascicularis]
0.0 [109..524] [1..399]

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Predicted Domain #1
Region A:
Residues: [1-39]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPDSKYTMQG YNLVKLLKRL EEATARLEDV TIYQEGYIQ

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [80-127]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AFQSYIGENI DPLVELSGKI DTVVLDALQL LKGGFQSQLT FLRAAVRS

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [136-247]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TFADSLRPIN ENIIKLGQLK ESNRQSKYFA YLSALSEGAP LFSWVAVDTP VSMVTDFKDA  60
   61 AQFWTNRILK EYRESDPNAV EWVKKFLASF DNLKAYIKEY HTTGVSWKKD GM

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.03
Match: 1k7lA
Description: Peroxisome proliferator activated receptor alpha, PPAR-alpha
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 5.81884714997094 bayes_pls_golite062009
cytoskeletal protein binding 4.39652693178112 bayes_pls_golite062009
adenylate cyclase binding 2.08284870927262 bayes_pls_golite062009
binding 1.8340549733034 bayes_pls_golite062009
enzyme binding 1.53072876683435 bayes_pls_golite062009
protein binding 0.871734119777931 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [40-79]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKLEASKNNK PSDSGADANT TNEPSAENAP EVEQDPKCIT 

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [128-135]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKPDYSSQ

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.03
Match: 1k7lA
Description: Peroxisome proliferator activated receptor alpha, PPAR-alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [248-353]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DFADAMAQST KNTGATSSPS PASATAAPAP PPPPPAPPAS VFEISNDTPA TSSDANKGGI  60
   61 GAVFAELNQG ENITKGLKKV DKSQQTHKNP ELRQSSTVSS TGSKSG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
actin binding 4.94933252861141 bayes_pls_golite062009
cytoskeletal protein binding 4.21664682046338 bayes_pls_golite062009
actin monomer binding 2.04365563273836 bayes_pls_golite062009
binding 1.57578562719958 bayes_pls_golite062009
adenylate cyclase binding 1.13353932343086 bayes_pls_golite062009
enzyme binding 0.705135358375 bayes_pls_golite062009
protein binding 0.651719649953198 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [354-526]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPPRPKKPST LKTKRPPRKE LVGNKWFIEN YENETESLVI DANKDESIFI GKCSQVLVQI  60
   61 KGKVNAISLS ETESCSVVLD SSISGMDVIK SNKFGIQVNH SLPQISIDKS DGGNIYLSKE 120
  121 SLNTEIYTSC STAINVNLPI GEDDDYVEFP IPEQMKHSFA DGKFKSAVFE HAG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 920.9897
Match: 1k4zA_
Description: C-terminal domain of adenylylcyclase associated protein
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle