YRC Public Data Repository - Protein Structure Prediction

Protein:	TCB2
Organism:	Saccharomyces cerevisiae
Length:	1178 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TCB2.

Description	E-value	Query Range	Subject Range
gi\|71064113 - gi\|71064113\|gb\|AAZ22521.1\| Tcb2p [Saccharomyces cerevisiae]	848.0	[0..1]	[1178..1]
gi\|49641952 - gi\|49641952\|emb\|CAH01670.1\| KLLA0C13860p [Kluyveromyces lactis] gi\|49641952, gi\|... - gi\|50305717\|ref\|XP_452819.1\| unnamed protein product [Kluyveromyces lactis], gi\|49641952\|emb\|CAH0167...	706.0	[0..12]	[1138..16]
gi\|6687541 - gi\|6687541\|emb\|CAB65007.1\| transmembrane protein [Erysiphe pisi]	704.0	[0..42]	[1165..105]
gi\|50291297, gi\|... - gi\|50291297\|ref\|XP_448081.1\| unnamed protein product [Candida glabrata], gi\|49527392\|emb\|CAG61032.1\|... gi\|49527392 - gi\|49527392\|emb\|CAG61032.1\| unnamed protein product [Candida glabrata]	662.0	[0..5]	[1139..42]
gi\|44984080 - gi\|44984080\|gb\|AAS53090.1\| AER411Wp [Ashbya gossypii ATCC 10895] gi\|44984080, gi\|... - gi\|45191012\|ref\|NP_985266.1\| AER411Wp [Ashbya gossypii ATCC 10895], gi\|44984080\|gb\|AAS53090.1\| AER41...	642.0	[0..1]	[1138..11]
YKH3_SCHPO - Uncharacterized protein PYUK71.03c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAPYUK... SPAPYUK71.03c - C2 domain protein	639.0	[0..11]	[1173..74]
gi\|38099370, gi\|... - gi\|39965448\|ref\|XP_365102.1\| hypothetical protein MG09947.4 [Magnaporthe grisea 70-15], gb\|EAA46726....	622.0	[0..59]	[1115..130]
gi\|169781998 - gi\|169781998\|ref\|XP_001825462.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|83774204 - gi\|83774204\|dbj\|BAE64329.1\| unnamed protein product [Aspergillus oryzae]	610.0	[0..84]	[1110..158]
gi\|115385264, gi... - gi\|115385264\|ref\|XP_001209179.1\| hypothetical protein ATEG_01814 [Aspergillus terreus NIH2624], gi\|1...	609.0	[0..3]	[1110..73]

Back

Predicted Domain #1

Region A:
Residues: [1-206]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPNSSKTRT DQISSMPGIN EATKVESKNV VKDAVPIKSE VETNGTSIVR EKQDPSYVGW  60
   61 KQVGGWEEKD ELTSEDLLVD VNKDTFLGNL LPDKFYGDWY HEVAILIIAG LCSFVLGYFK 120
  121 FSLASVLIVM LTTGMLYRTS SKKYRESLRD LAQKEQTVEK ITSDYESVEW LNTFLDKYWP 180
  181 IIEPSVSQQI VDGTNTALSE NVAIPK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [207-362]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FIKAIWLDQF TLGVKPPRID AIKTFQNTKS DVVVMDVCLS FTPHDMSDLD AKQCRNYVNS  60
   61 NVVLKAKIFG MDIPVSVADI FFQVFVRFRF QLMTTLPLVE TINIQLLEVP EVDFISRLLG 120
  121 NSVFNWEILA IPGLMRLIQK MAFKYLSPVL LPPFSL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	123.124002
Match:	1dqvA
Description:	Synaptogamin I
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [363-488]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLNIPQLLSK TGLPIGVLEI KVKNAHGLRK LVGMIKKTVD PYLTFELSGK IVGKTKVFKN  60
   61 SANPVWNESI YILLQSFTDP LTIAVYDKRE TLSDKKMGTV IFNLNKLHAN HYHKNEKVHF 120
  121 LRNSKP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	123.124002
Match:	1dqvA
Description:	Synaptogamin I
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [489-622]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGELTFDLRF FPTIEPKKLL NGDEEPLPDM NTGITKITIR ELKGLDELSD KKFVFAELYV  60
   61 NAELVMTTKK EKRTAHLKWN SDYYSVVTDR RKTICRFVLK DQSGKVISSS VQPLNHLIDR 120
  121 TEVNKEWIPL RNGK

[Run NCBI BLAST on this sequence.]

Detection Method:	ab initio
Confidence:	14.78
Match:
Description:	No description for 1bynA was found.

Predicted Domain #5

Region A:
Residues: [623-781]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GELKVTTYWR PVDIDLGLKS VGYTTPIGML RVFINKAENL RNPDSLGKIS PYAKVSVNGV  60
   61 ARGRTNERIE TLNPIWNQSI YVSVTSPLQK VSIDCFGIDT NGDDHNLGSL NIQTQNIYHK 120
  121 DNDDKYTIFI DNAPRTGNLI GKKGVKGTVT YYLSFYPVV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	50.751666
Match:	1k5wA
Description:	Synaptogamin I
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [782-922]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVLSLEEAKE VDEINEKKDK LEKQKSTLDD KNISKEEKER IKKEEFRLTE KYDMYSYKMK  60
   61 LDLDELLQYN AGVLGVTVLG GELPQPGLYV QTFFDSCGYA AITSAKNAIR TIKTGWSGDF 120
  121 MIKELEWSVT TFRVTKTKDA N

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7

Region A:
Residues: [923-1119]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KAENFICEVN IPTIELVRNC YYKPSVLNLI GKKSAKLLVQ VSWFPVTATE LPQSDLITNS  60
   61 GDLKITAKSA ENLIGVNKNG YSDPYVEFFL NEKSTSPFFK TAVQKKTLNP TWNESKTIEV 120
  121 SNRVNDYLTI NVKDYESTNS NRSIGKAVVP LSTIDPESDT TFNIPLVGPK GEDGGVLHLE 180
  181 FEFEPRYTTN VVKREAG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	88.9794
Match:	1rsyA
Description:	STRUCTURE OF THE FIRST C2-DOMAIN OF SYNAPTOTAGMIN I: A NOVEL CA2+(SLASH)PHOSPHOLIPID BINDING FOLD
Matching Structure (courtesy of the PDB):

Predicted Domain #8

Region A:
Residues: [1120-1178]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGNFATKGLG TGIKAGSTVF ALGTNVVSTG LGTIDKVKAG VFGGKKSTTT GDKKSEEKQ

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.454	N/A	N/A	a.64.2	Bacteriocin AS-48
View	Download	0.415	N/A	N/A	a.64.2	Bacteriocin AS-48
View	Download	0.407	N/A	N/A	a.7.17	Description not found.
View	Download	0.346	N/A	N/A	d.48.1	RecA protein, C-terminal domain
View	Download	0.341	N/A	N/A	a.4.1	Homeodomain-like
View	Download	0.333	N/A	N/A	a.4.1	Homeodomain-like
View	Download	0.331	N/A	N/A	a.4.1	Homeodomain-like

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits