YRC Public Data Repository - Protein Structure Prediction

Protein:	END3
Organism:	Saccharomyces cerevisiae
Length:	349 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for END3.

Description	E-value	Query Range	Subject Range
END3_YEAST - Actin cytoskeleton-regulatory complex protein END3 OS=Saccharomyces cerevisiae (strain ATCC 204508 /... END3 - EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall ...	4.0E-55	[1..349]	[1..349]
gi\|3377791 - gi\|3377791\|gb\|AAC28746.1\| SAGA [Emericella nidulans]	5.0E-54	[3..339]	[5..351]
EPS15L1 - epidermal growth factor receptor pathway substrate 15-like 1	2.0E-53	[2..348]	[121..526]
gi\|19577363 - gi\|19577363\|emb\|CAD28444.1\| probable SagA protein [Aspergillus fumigatus]	4.0E-52	[3..339]	[5..351]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	1.0E-51	[3..345]	[5..353]
gi\|218195438 - gi\|218195438\|gb\|EEC77865.1\| hypothetical protein OsI_17131 [Oryza sativa Indica Group] gi\|38344274, gi\|... - gi\|38344274\|emb\|CAE03753.2\| OSJNBa0013K16.2 [Oryza sativa (japonica cultivar-group)], gi\|215692742\|d...	2.0E-50	[38..283]	[283..539]
CML12_ARATH - Calmodulin-like protein 12 OS=Arabidopsis thaliana GN=CML12 PE=1 SV=3	5.0E-50	[43..313]	[11..294]

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Predicted Domain #1

Region A:
Residues: [1-98]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPKLEQFEIK KYWQIFSGLK PIENKVNHDQ VLPILYNSKL DSSVLNKIWF LADIDDDDNL  60
   61 DFEEFVICMR LIFDMVNKNI SSVPDELPDW LIPGSKVN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	128.156545
Match:	1eh2__
Description:	Eps15
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [99-180]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LIKERKKRKQ IENADLPPKK EIKVDWYMSP DDLNQYEKIY NSCAKLTDGT ITFNELSTKL  60
   61 STKFFNISKT DLNKVWSLIN PQ

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [181-274]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLPSIDRDPT FYFIHCLRQR NDLGAEIPAS LPNSLAEVCN KKQLSYDLRS SQPPTKRKEE  60
   61 ANEVDNLRDN GQNSSSDSSG SNVLSNEDSI KQKY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	38.221849
Match:	1iq5A_
Description:	Calmodulin
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [275-349]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASLTDDQVAN MREQLEGLLN YKKSEKTQGG SKLSKRINIR SITDDLDNIE QQVEVLENYL  60
   61 NNKRHELQAL QAEIN

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.924	0.038	protein binding, bridging	a.2.7	tRNA-binding arm

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits