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View Structure Prediction Details

Protein: PPA2
Organism: Saccharomyces cerevisiae
Length: 310 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PPA2.

Description E-value Query
Range
Subject
Range
PPA2 - pyrophosphatase (inorganic) 2
0.0 [3..310] [4..332]
IPYR2_YEAST - Inorganic pyrophosphatase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...
PPA2 - Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved i...
gi|207342089 - gi|207342089|gb|EDZ69960.1| YMR267Wp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190408492 - gi|190408492|gb|EDV11757.1| inorganic pyrophosphatase [Saccharomyces cerevisiae RM11-1a]
0.0 [1..310] [1..310]
IPYR2_MOUSE - Inorganic pyrophosphatase 2, mitochondrial OS=Mus musculus GN=Ppa2 PE=1 SV=1
0.0 [22..310] [18..328]
IPYR_BOVIN - Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) - Bos taurus (Bovin...
1.0E-98 [31..309] [1..285]
gi|5738218 - gi|5738218|gb|AAD50298.1|AF174582_1 inorganic pyrophosphatase [Torpedo marmorata]
1.0E-97 [34..309] [2..284]
IPYR_PICPA - Inorganic pyrophosphatase OS=Komagataella pastoris GN=IPP1 PE=3 SV=3
3.0E-97 [34..310] [3..281]

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Predicted Domain #1
Region A:
Residues: [1-310]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLLRMNALT SKARSIERLK QTLNILSIRN HRQFSTIQQG SKYTLGFKKY LTLLNGEVGS  60
   61 FFHDVPLDLN EHEKTVNMIV EVPRWTTGKF EISKELRFNP IVQDTKNGKL RFVNNIFPYH 120
  121 GYIHNYGAIP QTWEDPTIEH KLGKCDVALK GDNDPLDCCE IGSDVLEMGS IKKVKVLGSL 180
  181 ALIDDGELDW KVIVIDVNDP LSSKIDDLEK IEEYFPGILD TTREWFRKYK VPAGKPLNSF 240
  241 AFHEQYQNSN KTIQTIKKCH NSWKNLISGS LQEKYDNLPN TERAGNGVTL EDSVKPPSQI 300
  301 PPEVQKWYYV 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 832.38764
Match: 1e6aA_
Description: Inorganic pyrophosphatase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
inorganic diphosphatase activity 2.74116819406619 bayes_pls_golite062009
binding 1.77492613217844 bayes_pls_golite062009
catalytic activity 1.33262120571864 bayes_pls_golite062009
hydrolase activity 0.715768350203578 bayes_pls_golite062009
protein binding 0.38607803003281 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle