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View Structure Prediction Details

Protein: ZRC1
Organism: Saccharomyces cerevisiae
Length: 442 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ZRC1.

Description E-value Query
Range
Subject
Range
ZRC1 - Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; a...
gi|151945949 - gi|151945949|gb|EDN64181.1| Zinc resistance conferring protein [Saccharomyces cerevisiae YJM789]
gi|190408470 - gi|190408470|gb|EDV11735.1| zinc/cadmium resistance protein [Saccharomyces cerevisiae RM11-1a]
ZRC1_YEAST - Zinc/cadmium resistance protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ZRC1 PE=...
7.0E-97 [1..442] [1..442]
ZNT1_MOUSE - Zinc transporter 1 OS=Mus musculus GN=Slc30a1 PE=1 SV=1
7.0E-66 [5..418] [7..459]
ZNT1_RAT - Zinc transporter 1 OS=Rattus norvegicus GN=Slc30a1 PE=2 SV=1
3.0E-63 [5..418] [7..463]
ZHF1_SCHPO - Zinc homeostasis factor 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=zhf1 PE=2 SV=3
zhf1 - zinc ion transporter Zhf1
1.0E-62 [6..377] [7..378]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-62 [6..377] [7..378]
gi|16550925 - gi|16550925|gb|AAL25646.1|AF197329_1 zinc transporter [Eucalyptus grandis]
2.0E-60 [5..372] [54..419]

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Predicted Domain #1
Region A:
Residues: [1-442]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITGKELRII SLLTLDTVFF LLEITIGYMS HSLALIADSF HMLNDIISLL VALWAVDVAK  60
   61 NRGPDAKYTY GWKRAEILGA LINAVFLIAL CFSIMIEALQ RLIEPQEIQN PRLVLYVGVA 120
  121 GLISNVVGLF LFHDHGSDSL HSHSHGSVES GNNDLDIESN ATHSHSHASL PNDNLAIDED 180
  181 AISSPGPSGQ IGEVLPQSVV NRLSNESQPL LNHDDHDHSH ESKKPGHRSL NMHGVFLHVL 240
  241 GDALGNIGVI AAALFIWKTE YSWRYYSDPI VSLIITIIIF SSALPLSRRA SRILLQATPS 300
  301 TISADQIQRE ILAVPGVIAV HDFHVWNLTE SIYIASIHVQ IDCAPDKFMS SAKLIRKIFH 360
  361 QHGIHSATVQ PEFVSGDVNE DIRRRFSIIA GGSPSSSQEA FDSHGNTEHG RKKRSPTAYG 420
  421 ATTASSNCIV DDAVNCNTSN CL

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 69.259637
Match: PF01545
Description: Cation efflux family

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [72-442]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WKRAEILGAL INAVFLIALC FSIMIEALQR LIEPQEIQNP RLVLYVGVAG LISNVVGLFL  60
   61 FHDHGSDSLH SHSHGSVESG NNDLDIESNA THSHSHASLP NDNLAIDEDA ISSPGPSGQI 120
  121 GEVLPQSVVN RLSNESQPLL NHDDHDHSHE SKKPGHRSLN MHGVFLHVLG DALGNIGVIA 180
  181 AALFIWKTEY SWRYYSDPIV SLIITIIIFS SALPLSRRAS RILLQATPST ISADQIQREI 240
  241 LAVPGVIAVH DFHVWNLTES IYIASIHVQI DCAPDKFMSS AKLIRKIFHQ HGIHSATVQP 300
  301 EFVSGDVNED IRRRFSIIAG GSPSSSQEAF DSHGNTEHGR KKRSPTAYGA TTASSNCIVD 360
  361 DAVNCNTSNC L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.522879
Match: 2qfiA
Description: No description for 2qfiA was found.

Predicted functions:

Term Confidence Notes
cation transmembrane transporter activity 6.60087208506814 bayes_pls_golite062009
ion transmembrane transporter activity 6.49419690808578 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 6.066906606566 bayes_pls_golite062009
transporter activity 4.27173462293249 bayes_pls_golite062009
substrate-specific transporter activity 4.19993137135137 bayes_pls_golite062009
transmembrane transporter activity 4.18558383943492 bayes_pls_golite062009
cadmium ion transmembrane transporter activity 3.5658659940326 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.68106285271045 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 2.32644140472297 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.19343183150052 bayes_pls_golite062009
efflux transmembrane transporter activity 2.11491587250012 bayes_pls_golite062009
cation channel activity 1.89531256510168 bayes_pls_golite062009
ion channel activity 1.33777369753101 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 1.31663166812163 bayes_pls_golite062009
substrate-specific channel activity 1.28221434614717 bayes_pls_golite062009
passive transmembrane transporter activity 1.27960450391272 bayes_pls_golite062009
channel activity 1.27960450391272 bayes_pls_golite062009
binding 1.27456652114636 bayes_pls_golite062009
active transmembrane transporter activity 0.490905558612378 bayes_pls_golite062009
iron ion transmembrane transporter activity 0.376948884172728 bayes_pls_golite062009
protein binding 0.311357063667067 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle