YRC Public Data Repository - Protein Structure Prediction

Protein:	YMR178W
Organism:	Saccharomyces cerevisiae
Length:	274 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YMR178W.

Description	E-value	Query Range	Subject Range
YM44_YEAST - Uncharacterized protein YMR178W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YMR178W ... gi\|190408402 - gi\|190408402\|gb\|EDV11667.1\| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a] YMR178W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to bo...	1.0E-58	[1..274]	[1..274]
CINA_BACHD - Putative competence-damage inducible protein OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197... CINA_BACHD - Putative competence-damage inducible protein OS=Bacillus halodurans GN=cinA PE=3 SV=1	1.0E-53	[4..261]	[1..247]
gi\|221323087 - gi\|221323087\|ref\|ZP_03604381.1\| competence damage-inducible protein A [Bacillus subtilis subsp. subt... gi\|221318815 - gi\|221318815\|ref\|ZP_03600109.1\| competence damage-inducible protein A [Bacillus subtilis subsp. subt... gi\|221313892 - gi\|221313892\|ref\|ZP_03595697.1\| competence damage-inducible protein A [Bacillus subtilis subsp. subt... CINA_BACSU - Putative competence-damage inducible protein OS=Bacillus subtilis (strain 168) GN=cinA PE=3 SV=3 CINA_BACSU - Putative competence-damage inducible protein OS=Bacillus subtilis GN=cinA PE=3 SV=3	4.0E-53	[5..262]	[6..253]
gi\|2634065, gi\|1... - gi\|2634065\|emb\|CAB13566.1\| competence-damage inducible protein [Bacillus subtilis subsp. subtilis st... CINA_BACSU - Putative competence-damage inducible protein OS=Bacillus subtilis GN=cinA PE=3 SV=2	2.0E-52	[5..262]	[6..253]
CINA_CLOAB - Putative competence-damage inducible protein OS=Clostridium acetobutylicum GN=cinA PE=3 SV=1 CINA_CLOAB - Putative competence-damage inducible protein OS=Clostridium acetobutylicum (strain ATCC 824 / DSM 79...	2.0E-52	[4..265]	[1..254]
CINA_LISIN - Putative competence-damage inducible protein OS=Listeria innocua GN=cinA PE=3 SV=1 CINA_LISIN - Putative competence-damage inducible protein OS=Listeria innocua serovar 6a (strain CLIP 11262) GN=c...	3.0E-52	[6..261]	[4..249]
gi\|224501660 - gi\|224501660\|ref\|ZP_03669967.1\| competence damage-inducible protein A [Listeria monocytogenes FSL R2... gi\|254912072 - gi\|254912072\|ref\|ZP_05262084.1\| competence damage-inducible protein A [Listeria monocytogenes J2818] CINA_LISMO - Putative competence-damage inducible protein OS=Listeria monocytogenes serovar 1/2a (strain ATCC BAA... CINA_LISMO - Putative competence-damage inducible protein OS=Listeria monocytogenes GN=cinA PE=3 SV=1 gi\|254829844, gi... - gi\|254829844\|ref\|ZP_05234499.1\| competence damage-inducible protein A [Listeria monocytogenes 10403S... gi\|126943409, gi... - gi\|254898437\|ref\|ZP_05258361.1\| competence damage-inducible protein A [Listeria monocytogenes J0161]... gi\|133732945, gi... - gi\|254936399\|ref\|ZP_05268096.1\| competence damage-inducible protein A [Listeria monocytogenes F6900]... gi\|254827658, gi... - gi\|254827658\|ref\|ZP_05232345.1\| competence damage-inducible protein A [Listeria monocytogenes FSL N3...	6.0E-52	[6..261]	[4..249]
gi\|15924274, gi\|... - gi\|15924274\|ref\|NP_371808.1\| competence-damage inducible protein [Staphylococcus aureus subsp. aureu... gi\|15926867, gi\|... - gi\|15926867\|ref\|NP_374400.1\| competence-damage inducible protein cinA [Staphylococcus aureus subsp. ... gi\|25331000 - pir\|\|G89902 competence-damage inducible protein cinA [imported] - Staphylococcus aureus (strain N315... gi\|269202901\|ref... - competence/damage-inducible protein CinA [Staphylococcus aureus subsp. aureus ED98] gi\|90586588, gi\|... - gi\|90586588\|ref\|ZP_01242282.1\| Molybdopterin binding domain:Competence-damaged protein [Staphylococc... gi\|156721740, gi... - gi\|156979605\|ref\|YP_001441864.1\| competence-damage inducible protein [Staphylococcus aureus subsp. a... gi\|253316421 - gi\|253316421\|ref\|ZP_04839634.1\| competence-damage inducible protein [Staphylococcus aureus subsp. au... gi\|255006071 - gi\|255006071\|ref\|ZP_05144672.2\| competence-damage inducible protein [Staphylococcus aureus subsp. au... gi\|150393833, gi... - gi\|90583490\|ref\|ZP_01239246.1\| Molybdopterin binding domain:Competence-damaged protein [Staphylococc...	6.0E-52	[4..262]	[1..246]
CINAL_ECOLC - CinA-like protein OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=EcolC_1400 PE=3 SV=1 gi\|1799602, gi\|8... - gi\|89109066\|ref\|AP_002846.1\| hypothetical protein [Escherichia coli str. K-12 substr. W3110], gi\|179... gi\|124501889, gi... - gi\|124526418\|ref\|ZP_01698371.1\| competence/damage-inducible protein CinA [Escherichia coli B], gi\|12... CINA_ECOLI - CinA-like protein - Escherichia coli CINAL_ECODH - CinA-like protein OS=Escherichia coli (strain K12 / DH10B) GN=ECDH10B_2409 PE=3 SV=1 CINAL_ECOBW - CinA-like protein OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=BWG_2022 PE=3 SV=1 gi\|242377883, gi... - gi\|251785610\|ref\|YP_002999914.1\| hypothetical protein B21_02134 [Escherichia coli BL21], gi\|24237788... gi\|253323871, gi... - gi\|254289021\|ref\|YP_003054769.1\| competence damage-inducible protein A [Escherichia coli BL21(DE3)],... gi\|194436035, gi... - gi\|83588235\|ref\|ZP_00926860.1\| COG1058: Predicted nucleotide-utilizing enzyme related to molybdopter... gi\|254162260, gi... - gi\|254162260\|ref\|YP_003045368.1\| competence damage-inducible protein A [Escherichia coli B str. REL6... gi\|75512725, gi\|... - gi\|75512725\|ref\|ZP_00735227.1\| COG1058: Predicted nucleotide-utilizing enzyme related to molybdopter... EG14087 - inactive PncC family protein / Inactive PncC domain protein, function unknown; predicted molybdopter... EG14087 - inactive PncC family protein / Inactive PncC domain protein, function unknown; predicted molybdopter...	5.0E-51	[4..266]	[2..253]
gi\|254593544, gi... - gi\|254794144\|ref\|YP_003078981.1\| hypothetical protein ECSP_3126 [Escherichia coli O157:H7 str. TW143... gi\|208738435, gi... - gi\|208818312\|ref\|ZP_03258632.1\| CinA family protein [Escherichia coli O157:H7 str. EC4042], gi\|20873... gi\|208814175, gi... - gi\|208814175\|ref\|ZP_03255504.1\| CinA family protein [Escherichia coli O157:H7 str. EC4045], gi\|20873... gi\|208806502, gi... - gi\|208806502\|ref\|ZP_03248839.1\| CinA family protein [Escherichia coli O157:H7 str. EC4206], gi\|20872... gi\|195935628 - gi\|195935628\|ref\|ZP_03081010.1\| competence damage-inducible protein A [Escherichia coli O157:H7 str.... gi\|25331010, gi\|... - pir\|\|H85864 hypothetical protein Z3507 [imported] - Escherichia coli (strain O157:H7, substrain EDL... gi\|217319511, gi... - gi\|217327144\|ref\|ZP_03443227.1\| CinA family protein [Escherichia coli O157:H7 str. TW14588], gi\|2173... gi\|209157145, gi... - gi\|209395745\|ref\|YP_002271661.1\| CinA family protein [Escherichia coli O157:H7 str. EC4115], gi\|2091... gi\|15802798, gi\|... - gi\|15802798\|ref\|NP_288825.1\| competence damage-inducible protein A [Escherichia coli O157:H7 EDL933]... gi\|168761311, gi... - gi\|189368247\|gb\|EDU86663.1\| CinA family protein [Escherichia coli O157:H7 str. EC4501], gi\|168761311... gi\|15832391, gi\|... - gi\|15832391\|ref\|NP_311164.1\| competence damage-inducible protein A [Escherichia coli O157:H7], gi\|13... gi\|189357752, gi... - gi\|189357752\|gb\|EDU76171.1\| CinA family protein [Escherichia coli O157:H7 str. EC4401], gi\|168755002... gi\|168749659, gi... - gi\|188016108\|gb\|EDU54230.1\| CinA family protein [Escherichia coli O157:H7 str. EC4113], gi\|168749659... gi\|168798420, gi... - gi\|189378983\|gb\|EDU97399.1\| CinA family protein [Escherichia coli O157:H7 str. EC508], gi\|168798420\|... gi\|168780105, gi... - gi\|189001924\|gb\|EDU70910.1\| CinA family protein [Escherichia coli O157:H7 str. EC4076], gi\|168780105... gi\|168773024, gi... - gi\|187771213\|gb\|EDU35057.1\| CinA family protein [Escherichia coli O157:H7 str. EC4196], gi\|168773024... gi\|168767876, gi... - gi\|189362965\|gb\|EDU81384.1\| CinA family protein [Escherichia coli O157:H7 str. EC4486], gi\|168767876... gi\|15832391, gi\|... - gi\|15832391\|ref\|NP_311164.1\| competence damage-inducible protein A [Escherichia coli O157:H7 str. Sa...	7.0E-51	[4..266]	[2..253]

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Predicted Domain #1

Region A:
Residues: [1-139]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKVTAACII IGDEVLNGKV VDTNSTFFAK YCFDHGIQLK EIATIGDDET QIVDTVRRLV  60
   61 KNYDFIISTG GIGPTHDDIT YECMAKSFNL PCELDEECKE RMRHKSDPEA RLDADALKAH 120
  121 YQMATMPKGT NVKNYYVCD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	33.522879
Match:	1g8lA_
Description:	Molybdenum cofactor biosynthesis protein MoeA, C-terminal domain; Molybdenum cofactor biosynthesis protein MoeA, N-terminal and linker domains; MoeA, central domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.55991563183069	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [140-274]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLWVPICSIS HKMYILPGIP QLFARMLKAF TPTLKKIYNL DKDPREYVRY FVRTHLTESQ  60
   61 ISKELKLIQD ESTKVSEAIK IGSYPHFGMG FNTVSILGEK KDDSYLKSIV NRVVNNLEGE 120
  121 VISSELENKF SNQES

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.465	0.713	nucleus	a.22.1	Histone-fold
View	Download	0.355	0.058	cytoplasm	d.92.1	Metalloproteases ("zincins"), catalytic domain
View	Download	0.458	0.044	cytoplasm	a.100.1	6-phosphogluconate dehydrogenase C-terminal domain-like
View	Download	0.375	0.000	nucleus	a.24.17	Group V grass pollen allergen
View	Download	0.465	N/A	N/A	a.22.1	Histone-fold
View	Download	0.458	N/A	N/A	a.100.1	6-phosphogluconate dehydrogenase C-terminal domain-like
View	Download	0.449	N/A	N/A	a.22.1	Histone-fold
View	Download	0.449	N/A	N/A	a.22.1	Histone-fold
View	Download	0.375	N/A	N/A	a.24.17	Group V grass pollen allergen
View	Download	0.355	N/A	N/A	d.92.1	Metalloproteases ("zincins"), catalytic domain
View	Download	0.346	N/A	N/A	a.142.1	PTS-regulatory domain, PRD
View	Download	0.342	N/A	N/A	c.55.3	Ribonuclease H-like
View	Download	0.339	N/A	N/A	a.80.1	DNA polymerase III clamp loader subunits, C-terminal domain
View	Download	0.335	N/A	N/A	a.182.1	GatB/YqeY domain
View	Download	0.330	N/A	N/A	a.40.2	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain
View	Download	0.326	N/A	N/A	a.45.1	Glutathione S-transferase (GST), C-terminal domain
View	Download	0.321	N/A	N/A	a.74.1	Cyclin-like
View	Download	0.321	N/A	N/A	d.113.1	Nudix
View	Download	0.306	N/A	N/A	a.47.2	t-snare proteins
View	Download	0.305	N/A	N/A	a.116.1	GTPase activation domain, GAP
View	Download	0.292	N/A	N/A	d.153.1	N-terminal nucleophile aminohydrolases (Ntn hydrolases)
View	Download	0.290	N/A	N/A	f.36.1	Neurotransmitter-gated ion-channel pransmembrane pore
View	Download	0.286	N/A	N/A	f.36.1	Neurotransmitter-gated ion-channel pransmembrane pore
View	Download	0.274	N/A	N/A	c.23.6	Cobalamin (vitamin B12)-binding domain
View	Download	0.271	N/A	N/A	a.100.1	6-phosphogluconate dehydrogenase C-terminal domain-like
View	Download	0.270	N/A	N/A	c.24.1	Methylglyoxal synthase-like
View	Download	0.244	N/A	N/A	d.131.1	DNA clamp
View	Download	0.240	N/A	N/A	d.153.1	N-terminal nucleophile aminohydrolases (Ntn hydrolases)
View	Download	0.238	N/A	N/A	c.84.1	Phosphoglucomutase, first 3 domains
View	Download	0.231	N/A	N/A	d.15.4	2Fe-2S ferredoxin-like
View	Download	0.231	N/A	N/A	a.145.1	Flagellar transcriptional activator FlhD
View	Download	0.225	N/A	N/A	f.21.2	Fumarate reductase respiratory complex transmembrane subunits
View	Download	0.219	N/A	N/A	a.100.1	6-phosphogluconate dehydrogenase C-terminal domain-like
View	Download	0.202	N/A	N/A	c.55.7	Methylated DNA-protein cysteine methyltransferase domain

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: