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View Structure Prediction Details

Protein: ADE17
Organism: Saccharomyces cerevisiae
Length: 592 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ADE17.

Description E-value Query
Range
Subject
Range
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [8..592] [7..592]
gi|207342302 - gi|207342302|gb|EDZ70100.1| YMR120Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190408349 - gi|190408349|gb|EDV11614.1| bifunctional purine biosynthesis protein ADE17 [Saccharomyces cerevisiae...
gi|151945822 - gi|151945822|gb|EDN64054.1| 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase/IMP...
PUR92_YEAST - Bifunctional purine biosynthesis protein ADE17 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S28...
ADE17 - Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotid...
0.0 [1..592] [1..592]
PUR9_CHICK - Bifunctional purine biosynthesis protein PURH OS=Gallus gallus GN=ATIC PE=1 SV=1
0.0 [1..592] [1..593]
PUR9_MOUSE - Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide for...
0.0 [5..592] [4..592]
FBpp0292528, CG1... - This gene is referred to in FlyBase by the symbol Dmel\CG11089 (CG11089, FBgn0039241). It is a prote...
0.0 [5..592] [4..590]
PUR9_SCHPO - Bifunctional purine biosynthesis protein ade10 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843...
ade10 - IMP cyclohydrolase
0.0 [8..592] [3..585]

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Predicted Domain #1
Region A:
Residues: [1-197]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANYTKTAIL SVYDKTGLLD LARGLIEKNV RILASGGTAR MIRDAGFPIE DVSAITHAPE  60
   61 MLGGRVKTLH PAVHGGILAR DIDSDEKDLK EQHIEKVDYV VCNLYPFKET VAKVGVTIPE 120
  121 AVEEIDIGGV TLLRAAAKNH ARVTILSDPK DYSEFLSELS SNGEISQDLR NRLALKAFEH 180
  181 TADYDAAISD FFRKQYS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1g8mA_
Description: IMP cyclohydrolase domain of bifunctional purine biosynthesis enzyme ATIC; AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
formate dehydrogenase activity 2.1190774640451 bayes_pls_golite062009
catalytic activity 1.681309422157 bayes_pls_golite062009
binding 1.21541060770936 bayes_pls_golite062009
phosphoribosylaminoimidazolecarboxamide formyltransferase activity 1.20917335424321 bayes_pls_golite062009
deaminase activity 1.16510523659661 bayes_pls_golite062009
cytidine deaminase activity 0.870445440530128 bayes_pls_golite062009
oxidoreductase activity 0.738911503392967 bayes_pls_golite062009
hydroxymethyl-, formyl- and related transferase activity 0.56822429064158 bayes_pls_golite062009
carbon-oxygen lyase activity, acting on phosphates 0.344740566585736 bayes_pls_golite062009
glycine hydroxymethyltransferase activity 0.258234666901931 bayes_pls_golite062009
electron carrier activity 0.178707818321223 bayes_pls_golite062009
protein binding 0.072557222523031 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [198-378]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGQAQITLRY GANPHQKPAQ AYVSQQDSLP FKVLCGSPGY INLLDALNSW PLVKELSASL  60
   61 NLPAAASFKH VSPAGAAVGI PLSDVEKQVY FVADIENLSP LACAYARARG ADRMSSFGDW 120
  121 IALSNIVDVP TAKIISREVS DGVIAPGYEP EALAILSKKK GGKYCILQID PNYVPEAVER 180
  181 R

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1g8mA_
Description: IMP cyclohydrolase domain of bifunctional purine biosynthesis enzyme ATIC; AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [379-592]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QVYGVTLEQK RNDAIINQST FKEIVSQNKN LTEQAIIDLT VATIAIKYTQ SNSVCYARNG  60
   61 MVVGLGAGQQ SRIHCTRLAG DKADNWWFRQ HPRVLEIKWA KGVKRPEKSN AIDLFVTGQI 120
  121 PTEEPELSEY QSKFEEIPKP FTPEERKEWL SKLTNVSLSS DAFFPFPDNV YRAVKSGVKY 180
  181 IAAPSGSVMD KVVFSAADSF DLVYVENPIR LFHH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1g8mA_
Description: IMP cyclohydrolase domain of bifunctional purine biosynthesis enzyme ATIC; AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle