YRC Public Data Repository - Protein Structure Prediction

Protein:	YMR090W
Organism:	Saccharomyces cerevisiae
Length:	227 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YMR090W.

Description	E-value	Query Range	Subject Range
gi\|7437238 - pir\|\|H69105 dTDP-glucose 4,6-dehydratase - Methanobacterium thermoautotrophicum (strain Delta H) gi\|15679777, gi\|... - gi\|2622920\|gb\|AAB86255.1\| dTDP-glucose 4,6-dehydratase [Methanothermobacter thermautotrophicus str. ...	1.0E-71	[5..227]	[3..252]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	1.0E-71	[3..226]	[6..269]
gi\|10505382 - gi\|10505382\|gb\|AAG18457.1\|AF306787_1 AprE [Streptomyces tenebrarius]	1.0E-71	[4..226]	[1..257]
gi\|11270149, gi\|... - gi\|4574160\|gb\|AAD23919.1\|AF083467_3 dTDP-D-glucose 4,6-dehydratase [Neisseria meningitidis], pir\|\|G8... RMLB_NEIMA, RFBB... - dTDP-glucose 4,6-dehydratase OS=Neisseria meningitidis serogroup A GN=rfbB1 PE=3 SV=1, dTDP-glucose ... RMLB_NEIMA - dTDP-glucose 4,6-dehydratase OS=Neisseria meningitidis serogroup A / serotype 4A (strain Z2491) GN=r...	1.0E-70	[5..226]	[3..264]
gi\|4240415 - gi\|4240415\|gb\|AAD13546.1\| NDP-hexose 4,6-dehydratase homolog [Streptomyces cyanogenus]	1.0E-70	[4..226]	[2..254]
RMLB_NEIGO - dTDP-glucose 4,6-dehydratase OS=Neisseria gonorrhoeae GN=rfbB PE=3 SV=1	8.0E-70	[3..226]	[6..269]
gi\|1098478 - gi\|1098478\|gb\|AAC37049.1\| dTDP-D-glucose 4,6-dehydratase [Neisseria meningitidis]	1.0E-69	[5..226]	[3..264]
gi\|11270147 - pir\|\|G81242 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) NMB0063, NMB0079 [similarity] - Neisseria meni... RMLB_NEIMB, RFBB... - dTDP-glucose 4,6-dehydratase OS=Neisseria meningitidis serogroup B GN=rfbB1 PE=3 SV=2, dTDP-glucose ... RMLB_NEIMB - dTDP-glucose 4,6-dehydratase OS=Neisseria meningitidis serogroup B (strain MC58) GN=rfbB1 PE=3 SV=2	2.0E-69	[5..226]	[3..264]
gi\|209753446, gi... - pir\|\|A91219 dTDP-glucose 4,6-dehydratase [imported] - Escherichia coli (strain O157:H7, substrain R... gi\|189362621, gi... - gi\|189362621\|gb\|EDU81040.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC4486], gi\|... gi\|189365802, gi... - gi\|189365802\|gb\|EDU84218.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC4501], gi\|... gi\|13364196, gi\|... - gi\|15833975\|ref\|NP_312748.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7], gi\|13364196\|db... gi\|189358938, gi... - gi\|189358938\|gb\|EDU77357.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC4401], gi\|... gi\|168751746, gi... - gi\|188014279\|gb\|EDU52401.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC4113], gi\|... gi\|217325882, gi... - gi\|217325882\|ref\|ZP_03441966.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. TW14588]... gi\|209399629, gi... - gi\|209399629\|ref\|YP_002273306.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC4115]... gi\|13364196, gi\|... - gi\|15833975\|ref\|NP_312748.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. Sakai], gi\|... gi\|189376800, gi... - gi\|189376800\|gb\|EDU95216.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC508], gi\|1... gi\|189373224, gi... - gi\|189373224\|gb\|EDU91640.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC869], gi\|1... gi\|168780684, gi... - gi\|189001405\|gb\|EDU70391.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC4076], gi\|... gi\|168775664, gi... - gi\|187768885\|gb\|EDU32729.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC4196], gi\|... gi\|208818281, gi... - gi\|208818281\|ref\|ZP_03258601.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC4042],... gi\|208813029, gi... - gi\|208813029\|ref\|ZP_03254358.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC4045],... gi\|254595186, gi... - gi\|254795786\|ref\|YP_003080623.1\| dTDP-D-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. TW143... gi\|208725490, gi... - gi\|208805689\|ref\|ZP_03248026.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC4206],... gi\|195938077 - gi\|195938077\|ref\|ZP_03083459.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC4024]	4.0E-69	[5..226]	[3..264]
gi\|134102913, gi... - gi\|134102913\|ref\|YP_001108574.1\| dTDP-glucose 4,6-dehydratase [Saccharopolyspora erythraea NRRL 2338... gi\|567874 - gi\|567874\|gb\|AAA68211.1\| thymidine diphosphoglucose 4,6-dehydratase [Saccharopolyspora erythraea NRR...	8.0E-69	[4..226]	[1..255]

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Predicted Domain #1

Region A:
Residues: [1-227]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPMKVAVVG ASGKVGRLLI NQLKANDSFS TPLAIVRTQD QVNYFKNEVG VDASLTDIEN  60
   61 ASVSEITDAI KAYDAVVFSA GAGGKGMERI FTVDLDGCIK VVEACEKAGI KRFVVVSALK 120
  121 AEDRDFWYNI KGLREYYIAK RSADREVRNS NLDYTILQPG SLELNKGTGL LQPLDKLEEK 180
  181 ASVNYSINRE DVASFIVESL LHPNATVKKT ISLVNGNEPM EKFIQSL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	69.39794
Match:	1bxkB_
Description:	dTDP-glucose 4,6-dehydratase (RmlB)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.25481486078713	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: