YRC Public Data Repository - Protein Structure Prediction

Protein:	NAT4
Organism:	Saccharomyces cerevisiae
Length:	285 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NAT4.

Description	E-value	Query Range	Subject Range
NAT4_YEAST - Histone-specific N-acetyltransferase NAT4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) G... NAT4 - N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2...	9.0E-98	[1..285]	[1..285]
YJQ4_SCHPO - Uncharacterized N-acetyltransferase C825.04c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) ... SPCC825.04c - N-acetyltransferase	1.0E-32	[61..280]	[13..196]
gi\|12855273 - gi\|12855273\|dbj\|BAB30275.1\| unnamed protein product [Mus musculus]	3.0E-28	[79..253]	[86..238]
MSHD_CORGL - Mycothiol acetyltransferase OS=Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 ... MSHD_CORGL - Mycothiol acetyltransferase OS=Corynebacterium glutamicum GN=mshD PE=3 SV=1	5.0E-27	[60..249]	[122..285]
gi\|13376119, gi\|... - gi\|13376119\|ref\|NP_079047.1\| N-acetyltransferase 11 [Homo sapiens], gi\|10435991\|dbj\|BAB14720.1\| unna...	2.0E-26	[79..253]	[48..200]
gi\|220959068, gi... - gi\|220959068\|gb\|ACL92077.1\| CG7593-PA [synthetic construct], gi\|220950052\|gb\|ACL87569.1\| CG7593-PA [... CG7593-PA - This gene is referred to in FlyBase by the symbol Dmel\CG7593 (CG7593, FBgn0039687). It is a protein...	5.0E-23	[76..252]	[28..185]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	1.0E-22	[131..264]	[560..697]
gi\|699204 - gi\|699204\|gb\|AAA62968.1\| u2266n [Mycobacterium leprae]	2.0E-21	[61..246]	[131..297]

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Predicted Domain #1

Region A:
Residues: [1-128]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSSVYSENT YNCIRTSKEH LTERRRVAMA PMFQHFLNLC VEKFPESIEH KDTDGNGNFT  60
   61 TAILEREIIY IPEDDTDSID SVDSLKCINY KLHKSRGDQV LDACVQLIDK HLGAKYRRAS 120
  121 RIMYGNRK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.835	0.411	protein amino acid acetylation	a.1.1	Globin-like
View	Download	0.660	0.411	protein amino acid acetylation	a.25.1	Ferritin-like
View	Download	0.622	0.411	protein amino acid acetylation	d.58.20	NAD-binding domain of HMG-CoA reductase
View	Download	0.835	0.411	protein amino acid acetylation	a.1.1	Globin-like
View	Download	0.763	0.411	protein amino acid acetylation	a.1.1	Globin-like
View	Download	0.660	0.411	protein amino acid acetylation	a.25.1	Ferritin-like
View	Download	0.654	0.411	protein amino acid acetylation	a.1.1	Globin-like
View	Download	0.622	0.411	protein amino acid acetylation	d.58.20	NAD-binding domain of HMG-CoA reductase
View	Download	0.541	0.411	protein amino acid acetylation	a.74.1	Cyclin-like
View	Download	0.541	0.411	protein amino acid acetylation	a.24.3	Cytochromes
View	Download	0.528	0.411	protein amino acid acetylation	f.36.1	Neurotransmitter-gated ion-channel pransmembrane pore
View	Download	0.524	0.411	protein amino acid acetylation	a.22.1	Histone-fold
View	Download	0.522	0.411	protein amino acid acetylation	a.1.1	Globin-like
View	Download	0.507	0.411	protein amino acid acetylation	a.40.1	Calponin-homology domain, CH-domain
View	Download	0.503	0.411	protein amino acid acetylation	a.142.1	PTS-regulatory domain, PRD
View	Download	0.498	0.411	protein amino acid acetylation	a.74.1	Cyclin-like
View	Download	0.477	0.411	protein amino acid acetylation	a.24.4	Hemerythrin
View	Download	0.475	0.411	protein amino acid acetylation	a.1.1	Globin-like
View	Download	0.474	0.411	protein amino acid acetylation	a.74.1	Cyclin-like
View	Download	0.467	0.411	protein amino acid acetylation	a.24.3	Cytochromes
View	Download	0.457	0.411	protein amino acid acetylation	d.92.2	beta-N-acetylhexosaminidase-like domain
View	Download	0.455	0.411	protein amino acid acetylation	a.74.1	Cyclin-like
View	Download	0.437	0.411	protein amino acid acetylation	a.24.16	Nucleotidyltransferase substrate binding subunit/domain
View	Download	0.429	0.411	protein amino acid acetylation	a.1.1	Globin-like
View	Download	0.417	0.411	protein amino acid acetylation	a.118.8	TPR-like
View	Download	0.414	0.411	protein amino acid acetylation	a.24.1	Apolipoprotein
View	Download	0.410	0.411	protein amino acid acetylation	d.150.1	4'-phosphopantetheinyl transferase
View	Download	0.404	0.411	protein amino acid acetylation	a.24.9	alpha-catenin/vinculin
View	Download	0.402	0.411	protein amino acid acetylation	d.52.2	GMP synthetase C-terminal dimerisation domain
View	Download	0.402	0.411	protein amino acid acetylation	a.100.1	6-phosphogluconate dehydrogenase C-terminal domain-like
View	Download	0.401	0.411	protein amino acid acetylation	d.58.20	NAD-binding domain of HMG-CoA reductase
View	Download	0.398	0.411	protein amino acid acetylation	a.1.1	Globin-like
View	Download	0.392	0.411	protein amino acid acetylation	a.4.6	C-terminal effector domain of the bipartite response regulators
View	Download	0.388	0.411	protein amino acid acetylation	a.24.10	Histidine-containing phosphotransfer domain, HPT domain
View	Download	0.386	0.411	protein amino acid acetylation	a.1.1	Globin-like
View	Download	0.379	0.411	protein amino acid acetylation	d.58.21	Molybdenum cofactor biosynthesis protein C, MoaC
View	Download	0.375	0.411	protein amino acid acetylation	a.24.9	alpha-catenin/vinculin
View	Download	0.367	0.411	protein amino acid acetylation	f.36.1	Neurotransmitter-gated ion-channel pransmembrane pore
View	Download	0.366	0.411	protein amino acid acetylation	a.24.10	Histidine-containing phosphotransfer domain, HPT domain
View	Download	0.363	0.411	protein amino acid acetylation	a.45.1	Glutathione S-transferase (GST), C-terminal domain
View	Download	0.359	0.411	protein amino acid acetylation	a.60.9	lambda integrase-like, N-terminal domain
View	Download	0.356	0.411	protein amino acid acetylation	a.24.11	Bacterial GAP domain
View	Download	0.351	0.411	protein amino acid acetylation	a.74.1	Cyclin-like
View	Download	0.350	0.411	protein amino acid acetylation	d.52.2	GMP synthetase C-terminal dimerisation domain
View	Download	0.350	0.411	protein amino acid acetylation	a.118.1	ARM repeat
View	Download	0.349	0.411	protein amino acid acetylation	d.164.1	SMAD MH1 domain
View	Download	0.342	0.411	protein amino acid acetylation	d.189.1	PX domain
View	Download	0.335	0.411	protein amino acid acetylation	a.29.2	Bromodomain
View	Download	0.332	0.411	protein amino acid acetylation	a.77.1	DEATH domain
View	Download	0.331	0.411	protein amino acid acetylation	a.25.1	Ferritin-like
View	Download	0.328	0.411	protein amino acid acetylation	d.129.2	Phosphoglucomutase, C-terminal domain
View	Download	0.327	0.411	protein amino acid acetylation	d.41.4	Ribosomal protein L10e
View	Download	0.327	0.411	protein amino acid acetylation	a.74.1	Cyclin-like
View	Download	0.325	0.411	protein amino acid acetylation	a.177.1	Sigma2 domain of RNA polymerase sigma factors
View	Download	0.321	0.411	protein amino acid acetylation	a.100.1	6-phosphogluconate dehydrogenase C-terminal domain-like
View	Download	0.321	0.411	protein amino acid acetylation	a.1.1	Globin-like
View	Download	0.316	0.411	protein amino acid acetylation	a.118.8	TPR-like
View	Download	0.316	0.411	protein amino acid acetylation	a.24.7	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View	Download	0.313	0.411	protein amino acid acetylation	a.39.2	Insect pheromon/odorant-binding proteins
View	Download	0.313	0.411	protein amino acid acetylation	a.1.1	Globin-like
View	Download	0.308	0.411	protein amino acid acetylation	a.26.1	4-helical cytokines
View	Download	0.304	0.411	protein amino acid acetylation	d.228.1	Replication modulator SeqA, C-terminal DNA-binding domain
View	Download	0.302	0.411	protein amino acid acetylation	d.122.1	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View	Download	0.299	0.411	protein amino acid acetylation	a.29.5	alpha-ketoacid dehydrogenase kinase, N-terminal domain
View	Download	0.297	0.411	protein amino acid acetylation	d.122.1	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View	Download	0.293	0.411	protein amino acid acetylation	a.29.2	Bromodomain
View	Download	0.290	0.411	protein amino acid acetylation	a.118.1	ARM repeat
View	Download	0.290	0.411	protein amino acid acetylation	a.25.1	Ferritin-like
View	Download	0.284	0.411	protein amino acid acetylation	a.74.1	Cyclin-like
View	Download	0.283	0.411	protein amino acid acetylation	f.14.1	Voltage-gated potassium channels
View	Download	0.277	0.411	protein amino acid acetylation	a.182.1	GatB/YqeY domain
View	Download	0.276	0.411	protein amino acid acetylation	f.14.1	Voltage-gated potassium channels
View	Download	0.275	0.411	protein amino acid acetylation	a.45.1	Glutathione S-transferase (GST), C-terminal domain
View	Download	0.270	0.411	protein amino acid acetylation	a.7.8	GAT domain
View	Download	0.270	0.411	protein amino acid acetylation	a.24.10	Histidine-containing phosphotransfer domain, HPT domain
View	Download	0.269	0.411	protein amino acid acetylation	a.149.1	RNase III endonuclease catalytic domain
View	Download	0.266	0.411	protein amino acid acetylation	a.142.1	PTS-regulatory domain, PRD
View	Download	0.266	0.411	protein amino acid acetylation	f.18.1	F1F0 ATP synthase subunit A
View	Download	0.260	0.411	protein amino acid acetylation	d.58.20	NAD-binding domain of HMG-CoA reductase
View	Download	0.260	0.411	protein amino acid acetylation	a.185.1	Gametocyte protein Pfg27
View	Download	0.259	0.411	protein amino acid acetylation	f.18.1	F1F0 ATP synthase subunit A
View	Download	0.259	0.411	protein amino acid acetylation	d.58.49	YajQ-like
View	Download	0.255	0.411	protein amino acid acetylation	a.2.3	Chaperone J-domain
View	Download	0.254	0.411	protein amino acid acetylation	a.61.1	Retroviral matrix proteins
View	Download	0.250	0.411	protein amino acid acetylation	a.24.14	FAT domain of focal adhesion kinase
View	Download	0.248	0.411	protein amino acid acetylation	d.129.1	TATA-box binding protein-like
View	Download	0.247	0.411	protein amino acid acetylation	a.73.1	Retrovirus capsid protein, N-terminal core domain
View	Download	0.245	0.411	protein amino acid acetylation	a.25.1	Ferritin-like
View	Download	0.244	0.411	protein amino acid acetylation	a.59.1	PAH2 domain
View	Download	0.243	0.411	protein amino acid acetylation	a.74.1	Cyclin-like
View	Download	0.243	0.411	protein amino acid acetylation	a.1.1	Globin-like
View	Download	0.242	0.411	protein amino acid acetylation	d.52.3	Prokaryotic type KH domain (KH-domain type II)
View	Download	0.241	0.411	protein amino acid acetylation	d.95.2	Homing endonucleases
View	Download	0.239	0.411	protein amino acid acetylation	a.71.2	Helical domain of Sec23/24
View	Download	0.238	0.411	protein amino acid acetylation	a.60.8	HRDC-like
View	Download	0.238	0.411	protein amino acid acetylation	a.182.1	GatB/YqeY domain
View	Download	0.238	0.411	protein amino acid acetylation	a.25.1	Ferritin-like
View	Download	0.231	0.411	protein amino acid acetylation	a.74.1	Cyclin-like
View	Download	0.230	0.411	protein amino acid acetylation	a.1.1	Globin-like
View	Download	0.229	0.411	protein amino acid acetylation	d.58.44	Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View	Download	0.228	0.411	protein amino acid acetylation	a.118.8	TPR-like
View	Download	0.227	0.411	protein amino acid acetylation	c.95.1	Thiolase-like
View	Download	0.227	0.411	protein amino acid acetylation	a.118.9	ENTH/VHS domain
View	Download	0.225	0.411	protein amino acid acetylation	d.52.4	YhbC-like, N-terminal domain
View	Download	0.225	0.411	protein amino acid acetylation	d.4.1	His-Me finger endonucleases
View	Download	0.224	0.411	protein amino acid acetylation	a.71.2	Helical domain of Sec23/24
View	Download	0.219	0.411	protein amino acid acetylation	a.100.1	6-phosphogluconate dehydrogenase C-terminal domain-like
View	Download	0.213	0.411	protein amino acid acetylation	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.205	0.411	protein amino acid acetylation	a.7.2	Enzyme IIa from lactose specific PTS, IIa-lac
View	Download	0.202	0.411	protein amino acid acetylation	f.17.2	Cytochrome c oxidase subunit II-like, transmembrane region
View	Download	0.201	0.411	protein amino acid acetylation	a.70.1	N-terminal domain of the delta subunit of the F1F0-ATP synthase

Predicted Domain #2

Region A:
Residues: [129-285]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PWKANKLAEM KSAGLVYVCY WDNGVLGAFT SFMLTEETGL VEGDALHEVS VPVIYLYEVH  60
   61 VASAHRGHGI GRRLLEHALC DGVARHTRRM CDNFFGVALT VFSDNTRARR LYEALGFYRA 120
  121 PGSPAPASPT IRHTRHGGGR VVVPCDPLYY VYCLHMP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10.154902
Match:	1bo4A_
Description:	Aminoglycoside 3-N-acetyltransferase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits